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18 Cards in this Set

  • Front
  • Back
mechanism of general anesthetics
increase threshold for nerve cells to fire
Cl- channel opening causes hyperpolerization of axonal membrane
Na+ channel ligand-gated fns
activates K+ channels causing hyperpolerization
nitrous oxide
not a general anesthetic
effect of general anesthetics on respn
all decrease respiration
decreased respiration's effect on the brain
normally causes for vasodialation in brain wrt resp and CO2.
- not present in halothane or enflurane
spike and dome on EEG
seen with enflurane
like w/ epilepsy
pregnant pts general anesthesia
quiet and relaxation of uterine muscle w/ all
hepatic toxicity
halothane
nephrotoxicity
methoxytlutane
malignant hyperthermia
use dantrolene
- with all potent inhalation agents and succinylcholine
- sevofluane and sedflurane
ED50 for inhaled agents
= minimum alveolar concentration (MAC)
dose rqd for maintaining immobility in 50% of pop
- lower the MAC more potent the anesthetic agent
lower blood: gas partition coefficient
smaller # lowers the blood solubility
creates faster induction
- tissue solubility has minimal difference
pharmacokinetics of gas anesthetics
transfer from lung to blood to brain
partial pressure is pressure exerted by a specified component in a mixture of gases
partial pressure is equivelant
to the concentration gradient of a drug when you're administering it
when a gas dissolves in the blood
it makes it seem like there's a larger volume of blood
decreases the concentration gradient to get into the brain
partial pressure is no longer accurate
influences rate of induction of anesthesia
solubility
NO has low solubility (= small # for blood:gas partition coefficient) in blood and rapid induction

halothane has high solubility in blood and slower rate of induction
increasing the ventilation rate
increases the rate of induction
same as increasing the diffusion rate
cardiac output increased causes for ____rate of induction
induction to be slower
dt perceived increased blood capacity
pulmonary blood flow is slowed then anesthesia induction is _______
faster induction
dt reduced blood capacity