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12 Cards in this Set

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Spacer Sequence
Non-Coding DNA between genes
Introns
Non-Coding DNA within genes. Often contain more DNA than exons - make up the majority of DNA sequences in individual genes
Exons
Coding DNA sequences
Untranslated Region
Contained in exon but does not code for protein
Regulates translation and transcription
Generally at the end of gene sequences
Primary RNA Transcript
Contains both exons and introns
Alternative Splicing
Creation of different proteins from the same genes
(ABCD-->ABDC, BDAC, CABD etc)
On average each human gene codes for 3 proteins
Structure of Mitochondrial DNA
One circular, double-stranded DNA molecule
Mitchondrial Genome Inheritance
Sperm contributes only nuclear DNA to zygote, mitochondrial DNA comes from egg
Whole Shotgun Approach
Examines similarities in fragments and has computer reassemble based on landmarks and where fragments overlap
Nested Shotgun Approach
Orders pieces of sequence first, then blasts it and reassembles based on initial understanding
Methods to study proteins
1-Seperation by 2-D gel electrophoresis using size and charge
2-Study the binding partners or a protein
3-Protein Chip:studying the binding partners
4-Protein structure
How will proteomics help drug R&D?
Better predicition of drug interactions and efficacy