Gen Pharm

Front 1

Sympathetic (A1)

Back 1

Gq

inc vascular smooth m contraction
inc pupillary dilator muscle contraction (mydriasis)

Front 2

Sympathetic (A2)

Back 2

Gi

dec symp outflow
dec insulin release

Front 3

Sympathetic (B1)

Back 3

Gs

inc heart rate, inc contractility
inc renin release
inc lipolysis

Front 4

Sympathetic (B2)

Back 4

Gs

vasodilation, bronchodilation
inc heart rate, inc contractility
inc lipolysis
inc glucagon release
dec uterine tone

Front 5

Para (M1)

Back 5

Gq

CNS, enteric nerv sys

Front 6

Para (M2)

Back 6

Gi

dec HR, contractiilty of atria

Front 7

Para (M3)

Back 7

Gq

inc exocrine gland secretion
inc gut peristalsis
inc bladder contraction
bronchoconstriction
inc pupillary sphincter muscle contraction (miosis)
ciliary muscle contraction (accomodation)

Front 8

D1

Back 8

Gs

Relax renal vasc smooth m

Front 9

D2

Back 9

Gi

Modulate transmitter release esp in brain

Front 10

H1

Back 10

Gq

inc nasal and bronchial mucus prod
contraction of bronchioles
pruritis
pain

Front 11

H2

Back 11

Gs

inc gastric acid secretion

Front 12

Vasopressin (V1)

Back 12

Gq

inc vascular smooth muscle contraction

Front 13

Vasopressin (V2)

Back 13

Gs

inc H20 permeability and reabsorp in CT of kidney

Front 14

Gq

Back 14

PLC --> PIP2 --> IP3 + DAG --> Inc Ca2+ and Prot KinaseC

Front 15

Gs

Back 15

Adenylyl cyclase --> (ATP) --> cAMP --> Prot Kinase A

Front 16

Gi

Back 16

Adenylyl Cyclase --> dec cAMP --> dec Prot Kinase A

Front 17

Bethanechol

Back 17

Postop and neurogenic ileus and urinary retention

Activates bowel and bladder smooth m; resist to AChE

Front 18

Carbachol

Back 18

Glaucoma, pupillary contraction, release of intraocular pressure

Front 19

Pilocarpine

Back 19

Potent stimulator of sweat, tears, saliva

Contracts ciliary m of eye (open angle), pupillary sphincter (narrow angle); resistant to AChE

Front 20

Methacholine

Back 20

Challenge test for dx of asthma

Stim muscarinic receptors in airway when inhaled.

Front 21

Neostigmine

Back 21

Postop and neurogenic ileus and urinary retntion, Myasthenia Gravis, rev of NMJ blockade

Inc endogenous ACh
no CNS penetration

Front 22

Pyridostigmine

Back 22

Myasthenia Gravis (long acting)
Does not penetrate CNS

Inc endog ACh
Inc strength

Front 23

Edrophonium

Back 23

Dx of MG (extremely short acting)

Inc endog ACh

Front 24

Physostigmine

Back 24

Glaucoma (cross BBB-->CNS)
Atropine OD

Inc endog ACh

Front 25

Echothiophate

Back 25

Glaucoma

Inc endogeous ACh

Front 26

Cholinesterase inhibitor poisoning

Back 26

Diarrhea
Urination
Miosis
Bronchospasm
Bradycardia
Excitation of skel muscle & CNS
Lacrimation
Sweating
Salivation

Antidote: atropine + Pralidoxime

Front 27

Atropine, Homatropine, Tropicamide

Back 27

Eye

Produce mydriasis and cycloplegia

Front 28

Benztropine

Back 28

CNS

Parkinson's

Front 29

Scopolamine

Back 29

CNS

Motion sickness

Front 30

Ipratropium

Back 30

Respiratory

Asthma, COPD

Front 31

Oxybutynin, Glycopyrrolate

Back 31

GU

Reduce urgency in mild cystitis and reduce bladder spasms

Front 32

Methscopolamine, Pirenzepine, Propantheline

Back 32

GI

Peptic ulcer treatment

Front 33

Atropine

Back 33

Musc antag

Inc pupil dilation, cycloplegia
Dec airway secretions
Dec acid secretion
Dec GI motility
Dec urgency in cytitis
Tox: Inc body temp, rapid pulse, dry mouth, dry flushed skin, cycloplegia, constipation, disorientation
Acute angle-closure glaucoma in elderly, urinary retention in men w/ prostatic hyperplasia, and hyperthermia in infants

Front 34

Hexamethonium

Back 34

Nicotinic antag

Ganglionic blocker

Tox: severe orthostatic hypoTN, blurred vision, constipation, sex dysfxn

Front 35

Epinephrine

Back 35

A1, A2, B1, B2

Anaphylaxis, glaucoma, asthma, hypoTN

Front 36

NE

Back 36

A1, A2 > B1

HypoTN (but dec renal perfusion)

Front 37

Isoproterenol

Back 37

B1 = B2

AV block

Front 38

Dopamine

Back 38

D1 = D2 > B > A

Shock (inc renal perfusion), HF (inotropic + chronotropic)

Front 39

Dobutamine

Back 39

B1 > B2

Shock, HF, cardiac stress testing (inotropic only)

Front 40

Phenylephrine

Back 40

A1 > A2

Pupillary dilation, vasoconstriction, nasal decongestion

Front 41

Albuterol, Terbutaline

Back 41

B2 > B1

Acute asthma (albuterol)
Reduce premature labor contractions (Terbutaline)

Front 42

Ritodrine

Back 42

B2

Reduce premature labor contractions

Front 43

Amphetamine

Back 43

Indirect gen agonist, release stored catecholamines

Use in Narcolepsy, obesity, ADD

Front 44

Ephedrine

Back 44

Indirect general agonist, release stored catecholamines

Use in nasal decongestion, urinary incontinence, hypoTN

Front 45

Cocaine

Back 45

Indirect general agonist, uptake inhibitor

cause vasoconstriction and local anesthesia

Front 46

Clonidine, alpha-methyldopa

Back 46

Central acting a2-agonist, dec central adrenergic outflow

Use in HTN (esp w/ renal dz - no dec in BF to kidney)

Front 47

Selective B2 agonists

Back 47

Metaproterenol
Albuterol
Salmeterol
Terbutaline

Front 48

Phenoxybenzamine, Phentolamine

Back 48

Nonselective alpha-blockers

Use in pheochromocytoma

Tox: orthostatic hypoTN, reflex tachy

Front 49

Prazosin, terazosin, doxazosin

Back 49

A1 selective

Use in HTN, urinary retention in BPH

Tox: 1st dose orthostatic hypoTN, dizziness, headache

Front 50

Kitchen

Back 50

Cocina

Front 51

B-blockers

Back 51

Acebutolol, Betaxolol, Esmolol, Atenolol, Metaprolol, Proparnolol, Timolol, Pindolol, Labetalol

HTN - dec CO, dec renin secretion
Angina - dec HR/contractility, dec O2 consumption
MI - dec mortality
SVT - dec AV conduc vel (class II)
CHF - slow prog of chronic failure
Glaucoma (Timolol) - dec sec of aq humor

Tox: impotence, exacerbation of asthma, CV adverse effects, CNS

Front 52

B1 selective

Back 52

Betaxolol
Esmolol
Acebutolol
Ateolol
Metaprolol

Front 53

P450 Inducers

Back 53

Quinidine
Barbs
St Johns wart
Phenytoin
Rifampin
Griseofulvin
Carbamezapine

Front 54

P450 Inhibitors

Back 54

Sulfonamides
INH
Cimetidine
Ketoconazole
Erythromycin
Grapefruit juice