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45 Cards in this Set

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Physiologic Action of gastrin
Stimulates acid secretion and growth of gastric oxyntic gland mucosa
Site of Release of Gastrin
Gastric antrum and duodenum
Stimulus for release of Gastrin
Peptides, amino acids, distention, vagal stimulation
Physiologic Action CCK
Stimulates gallbladder contraction, pancreatic enzyme and bicarbonate secretion, and growth of exocrine pancreas
Site of release of CCK.
Duodenum and jejunum
Stimulus for release of CCK
Peptides, amino acids, long chain fatty acids, (acid)
Physiologic action of Secretin
Stimulates pancreatic bicarbonate secretion, biliary bicarbonate secretion, growth of exocrine pancreas, pepsin secretion; inhibits gastric acid secretion, trophic effects of gastrin
Site of release of Secretin
Duodenum
Stimulus for release of secretin
Acid (fat)
Physiologic ACtion of GIP
Stimulates insulin release; (inhibits gastric acid secretion)
Site of release of GIP
Duodenum and jejunum
Stimulus for releaseo f GIP
Glucose, amino acids, fatty acids
Physiologic action of Motilin
Stimulates gastric and duodenal motility
Site of release of Motilin
Duodenum and jejunum
Pancreatic Polypeptids
Inhibits pancreatic bicarbonate and enzyme secretion
Site of release of Pancreatic Polypeptide
Pancreatic islets of Langerhans
Stimulus for relese of pancreatic polypeptide
Protein (fat and glucose)
Physiologic function of somatostatin
Inhibits release of most other peptide hormones
Site of release of somatostatin
GI tract mucosa, pancreatic islets of Langerhans
Stimulus for release of somatostatin
Acid stimulates, vagus inhibits release
Complication associated with somatostatin
gallstones
Physiological function of prostoglandins
Promote blood flow, increase mucus and bicarbonate secretion from gastric mucosa
Complication associated with prostaglandins
NSAID-induced gastritis and ulcer disease
Physiologic action of histamine
Stimulates gastric acid secretion
Site of release of histamine
Oxyntic gland mucosa
Physiologic action of VIP
Relaxes sphincters and gut circular muscle; stimulates intestinal and pancreatic secretion
Site of release of VIP
Mucosa and smooth muscle of GI tract
Stimulus for release of VIP
Enteric nervous system
Complications associated with VIP
Secretory diarrhea
Physiologic actions of Bombesin
Stimulates gastrin release
Site of release of Bombesin
Enteric nervous system
Physiological action of Enkephalins
Stimulate smooth muscle contraction; inhibit intestinal secretion
Site of release of enkaphalins
Mucosa and smooth muscle of GI tract
Stimulus for release of enkapalins
Enteric nervous system
Physiologic action of Intrinsic factor
Binds vitamin B12 to facilitate its absorption
Site of relase of intrinsic factor
Parietal cells of the stomach
Type of secretion associated with intrinsic factor
Constitutive secretion
Physiologic action of Mucin
Lubrication and protection
Site of release of Mucin
Goblet cells along entire GI tract mucosa
Stimulus for relase of Mucin
GI tract irritation
Disease's associated with Mucin
Viscid mucus in cystic fibrosis. Attenuation in some cases of peptic ulcer.
Physiologic action of Acid
Prevents infection; initiates digestion
Site of release of Acid
Parietal cells of the stomach
Stimulus for release of Acid
Gastrin, histamine, acetylcholine, NSAIDs (indirectly)
Diseases associated with Acid.
Acid-peptic disease