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45 Cards in this Set
- Front
- Back
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Physiologic Action of gastrin
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Stimulates acid secretion and growth of gastric oxyntic gland mucosa
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Site of Release of Gastrin
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Gastric antrum and duodenum
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Stimulus for release of Gastrin
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Peptides, amino acids, distention, vagal stimulation
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Physiologic Action CCK
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Stimulates gallbladder contraction, pancreatic enzyme and bicarbonate secretion, and growth of exocrine pancreas
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Site of release of CCK.
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Duodenum and jejunum
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Stimulus for release of CCK
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Peptides, amino acids, long chain fatty acids, (acid)
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Physiologic action of Secretin
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Stimulates pancreatic bicarbonate secretion, biliary bicarbonate secretion, growth of exocrine pancreas, pepsin secretion; inhibits gastric acid secretion, trophic effects of gastrin
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Site of release of Secretin
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Duodenum
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Stimulus for release of secretin
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Acid (fat)
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Physiologic ACtion of GIP
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Stimulates insulin release; (inhibits gastric acid secretion)
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Site of release of GIP
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Duodenum and jejunum
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Stimulus for releaseo f GIP
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Glucose, amino acids, fatty acids
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Physiologic action of Motilin
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Stimulates gastric and duodenal motility
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Site of release of Motilin
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Duodenum and jejunum
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Pancreatic Polypeptids
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Inhibits pancreatic bicarbonate and enzyme secretion
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Site of release of Pancreatic Polypeptide
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Pancreatic islets of Langerhans
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Stimulus for relese of pancreatic polypeptide
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Protein (fat and glucose)
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Physiologic function of somatostatin
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Inhibits release of most other peptide hormones
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Site of release of somatostatin
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GI tract mucosa, pancreatic islets of Langerhans
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Stimulus for release of somatostatin
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Acid stimulates, vagus inhibits release
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Complication associated with somatostatin
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gallstones
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Physiological function of prostoglandins
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Promote blood flow, increase mucus and bicarbonate secretion from gastric mucosa
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Complication associated with prostaglandins
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NSAID-induced gastritis and ulcer disease
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Physiologic action of histamine
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Stimulates gastric acid secretion
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Site of release of histamine
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Oxyntic gland mucosa
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Physiologic action of VIP
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Relaxes sphincters and gut circular muscle; stimulates intestinal and pancreatic secretion
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Site of release of VIP
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Mucosa and smooth muscle of GI tract
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Stimulus for release of VIP
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Enteric nervous system
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Complications associated with VIP
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Secretory diarrhea
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Physiologic actions of Bombesin
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Stimulates gastrin release
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Site of release of Bombesin
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Enteric nervous system
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Physiological action of Enkephalins
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Stimulate smooth muscle contraction; inhibit intestinal secretion
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Site of release of enkaphalins
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Mucosa and smooth muscle of GI tract
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Stimulus for release of enkapalins
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Enteric nervous system
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Physiologic action of Intrinsic factor
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Binds vitamin B12 to facilitate its absorption
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Site of relase of intrinsic factor
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Parietal cells of the stomach
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Type of secretion associated with intrinsic factor
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Constitutive secretion
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Physiologic action of Mucin
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Lubrication and protection
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Site of release of Mucin
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Goblet cells along entire GI tract mucosa
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Stimulus for relase of Mucin
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GI tract irritation
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Disease's associated with Mucin
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Viscid mucus in cystic fibrosis. Attenuation in some cases of peptic ulcer.
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Physiologic action of Acid
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Prevents infection; initiates digestion
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Site of release of Acid
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Parietal cells of the stomach
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Stimulus for release of Acid
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Gastrin, histamine, acetylcholine, NSAIDs (indirectly)
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Diseases associated with Acid.
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Acid-peptic disease
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