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10 Cards in this Set

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  • Back
Mecamylamine
-A ganglionic blocker
Used in: hypertensive crisis, controlled hypotension in surgery (to decrease blood flow), hyperreflexia in spinal injuries, tourettes, cocaine/nicotine withdrawal
Neuromuscular blockers
-ligand gated ion channel
-nicotinic receptor 5 subunits
-muscle a2, b, gamma, delta
-neural a3b2
-2 molecules ACh must bind
Succinylcholine
-Depolarizing blocker, agonists
-Rapidly metabolized by plasma esterases
-Onset: 1-1.5 mins, duration 5-8 mins
Mechanism of Succinylcholine
1) Briefly activates receptor: muscle fasciculations, bradycardia then tachycardia
2) Desensitizes motor endplate paralysis
Uses: Surgery, intubations, fractures, electroshock (to relax during shock), convulsive disorders
Side Effects if Succinylcholine
-Histamine release on rapid infusion (hypotension, bronchospasm)
-K+ release (avoid with tissue damage)
-abnormal enzyme for metabolism
-malignant hyperthermia (heat generated from contraction of muscle due to large release of Ca++), can be treated with dantrolene sodium and ice
-infants less sensitive
D-tubocurarine
-Non-depolarizing antagonist
-Chondrodendron bark, alkaloid
-South American arrow poison
-Does not cross GI or BBB
-NO anesthetic properties
-4 to 6 minute onset, 80-120 min duration
-Progressive paralysis: fingers, toes, facial muscles, eyes, then limbs, neck trunk, then intercostal muscles, then diaphragm
Uses for D-tubocurarine
Surgery, electroconvulsive shock, muscle spasms
Side effects of D-tubocurarine
histamine release, newborns are extremely sensitive, interacts with anesthetic gases, aminoglycosides, hypokalemia, local anesthetics
-Antidote Physostigmine
Pancuronium
-Steroid nucleus
-No histamine release, medium ganglionic blocking effects
-5 to 10 times more potent than curare
Doxacurium
-Benzylisoquinolinium derivative
-2 to 3 times more potent than pancuronium.. MOST potent
-Low histamine and ganglion effects