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442 Cards in this Set
- Front
- Back
- 3rd side (hint)
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malassezia mc
|
malassezia globosa
|
|
|
|
what human peptide plays a role in malassezia
|
LL-37
|
|
|
|
cultured on C12-C14 fatty acids
asparagine stimulates growth glycine stimulates hyphal formation |
malassezia
|
|
|
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endopthalmitis of newborn cause
|
candida albicans
mc cause of intraocular infection assoc low birth weight |
|
|
|
candida glabrata
|
15-20% candida infections
(15-25% fluconazole resistant) |
|
|
|
candida krusei
|
1-3% of candida infections
resistant to fluconazole |
|
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candida dubliniensis
|
assoc w HIV
|
|
|
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candida lusitaniae
|
resisant to ampho B
|
|
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what culture medium induces chlamydoconidia in candida
|
cornmeal tween agar
|
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trichosporon beigelii
|
soil
yeast 28-30 C |
|
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exophilia werneckii
|
adapt to high salinity environments
F > M |
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borderline leprosy
|
5+ erythematous annular plaques
|
|
|
|
M leprae grows
|
cellular division once per 2 wks
27 to 35 C |
|
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Ridley-Hopling Classificiation
|
5 types of leprosy
prognosis TT-BT-IT-BL-LL |
|
|
|
Tuberculoid leprosy
|
< 5 psoriasiform lesions and nerve changes
kids mc TT |
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intermediate leprosy
|
subtle hypopigmented lesions
|
|
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Leprosy treatment
|
tuberculoid 6 mths rifampin and dapsone
LL 24 mths, dapsone, rifampin, clofazimine |
|
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Lucio's phenomenon clinical
|
ulceration on background of induration
|
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Type 1 reaction
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nodules in preexisting lesions
|
|
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Type 2 reactions
|
ENL
increase TNFalpha immune complex deposition skin nodules on normal skin, fever, joint and muscle pain TOC thalidomide |
|
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|
Rhinoscleroma stain? Culture?
|
warthin-starry and PAS
McConkey agar |
|
|
|
Rhinoscleroma treatment
|
antibiotics and prednisone
cipro > 18 yo Cefixime Rifampin Clindamycin |
|
|
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vibrio vulnificus
|
gram - short motile bacteria
preparation or ingestion raw seafood food borne illness highest rate of mortality 39% |
|
|
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rhinoscerloma
Mikulicz cells (mo with phagocytosed large round collections of bacilli) |
|
|
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ecthyma gandrenosum
|
psuedomonas aeruginosa
hemmorhagic pustules or infacted appearance w surrounding erythema evolves into necrotic ulcers histo necrosis of deep dermal vessels amphophilic baccil surrounding vessels (light blue haze) no inflamamtory infiltrate around vessels variable hemorrhage and cutaneous necrosis |
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propionbacterium acnes
|
G+ rod
|
|
|
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Nocardia
|
G+, catalase +, aerobic rod
|
|
|
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Actinomyces israelii
|
purluent dc when excise
yellow sulfur granules surgically drain and high dose PCN |
|
|
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kinetoplast
|
disk shaped mass of circular DNA inside mitochondria
|
|
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|
Penicillium marnefii
|
saprophyte
dimoprhic 3rd mc HIV in SE Asia bamboo rats mold 37 C and yeast 37 C binary fission, not budding Clinically S2 cyrpto (bone marrow, skin,blood, sputum) small yeasts in mo culture conidiophores with five phialides |
|
|
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conidiophores with five phialides
|
penicillium marnefii
|
|
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BCC ALDARA INCREASE WHAT TYPE OF CELL?
|
CD4+ AND ALSO NKC
|
|
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SCC FOXP3
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DECREASE FOXP3
|
|
|
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ANTIMALARIAL EYES
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CHLOROQUINE
|
|
|
|
PF VS PV DRUG ASSOCIATED
|
PF = THIOL GROUP
PV = AMIDE GROUP ENALAPRIL PV AND MM |
|
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GUM HYPERTROPHY NON-INFLAMMATORY
|
DIHYDROPYRIDINE CCB
AMLODIPINE FELODIPINE NIFEDIPINE 2-3 MTHS INCREASE FIBROBLAST DNA NON DIHYDROSPYRIDINE DILT AND VERAMPIMIL NO GUM HYPERTROPHY |
|
|
|
AGEP
|
LAMISIL
ITRACONAZOLE ANTICONVULSANTS CCBS CARBAMAZEPINE PHENYTOIN HIGH FEVER, INCREASE NO, PATCH TESTING |
|
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DAPSONE MOTOR NEROPATHY RESOLVE?
|
MTHS TO YRS
|
|
|
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PHENYTONIN DRUG HYPERSENSITIVITY
|
INTERSTITIAL PNA, HEPATITIS, ASEPTIC MENN
AUTOIMMUNE THRYOID |
|
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AGEP ARTHRALGIAS?
|
NO
|
|
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SULFONAMIDE
|
SLOW ACETYLATORS
|
|
|
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DAPSONE METABOLISM
|
1. N-ACETYL
2. N-HYDROXY CIMETIDINE INHIBITS N-HYDROXY DECREASE TOXIC INCREASE PLASMA DAPSONE DECREASE METHEMOGLOBINEMIA |
|
|
|
TYPES OF AZOLES
KETOCONAZOLE FLUCONAZOLE ITRACONAZOLE |
KETOCONAZOLE IMIDAZOLE
FLUCONAZOLE AND ITRACONAZOLE TRIAZOLE |
|
|
|
BLOODY ONYCHOLYSIS
|
TAXANES
DOCETAXEL > PACLITAXEL 40% |
|
|
|
SLE DRUG +
|
+ P-ANCA
|
|
|
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MACROLIDES INTERACT WTIH
|
CARBAZEMPINE
STATINS CYCLSPROINE ALPRAZOLAM |
|
|
|
DECREASE 1ST PASS LIVER
|
GRAPEFRUIT
NIFEDIPINE SAQUIAVIR MIDAZOLAM LORASTATIN |
|
|
|
IVIG
|
FAB2
|
|
|
|
2D6
|
NORTRIPTYLINE
DESIPRAMINE METOPROLOL |
|
|
|
TETRACYCLILNE AND MMPS
|
COLLAGENASES 8,13
GELATINASES 2, 9 ELASTASES 12 |
|
|
|
TETRACYCLINES DECREASE
|
NO AND ARACHIDONIC ACID PATHWAY
|
|
|
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IMURAN INACTIVE METABOLITES
|
XO
|
|
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PCT MED
|
LASIX
|
|
|
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TEN MC
|
SULFAMIDS 20%
ANTICONVUSANTS ALLOPURINOL NSAIDS |
|
|
|
CEFDINIR
|
G+ G-
MOST ACTIVE CEPHALOSPORIN SA, STREP NO MRSA OR PEUDOMONAS |
|
|
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SERUM SICKNESS LIKE DRUG
|
MINOCYCLINE
|
|
|
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OXANDRIONE
|
ANABOLIC TX ANGIOEDEMA
|
|
|
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ANTIVIRALS INHIBIT
|
DNA POLYMERASE
|
|
|
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VORINOSTAT
|
TX CTCL
HISTONE DEACETYLASES 1,2,3,6 INCREASE HISTONE ACETYLATION PE, DVT, ANEMIA MC GI, TASTE |
|
|
|
TARAZAC KERATINS
|
DECREASE K6, K16
|
|
|
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CANTHARIDIN DECREASE
|
I AND PP2A
|
|
|
|
ERYTHROMYCIN AND AZOLES
AND STATINS |
NO
INCREASE RHABDO AND RENAL FAILURE CYP3A4 |
|
|
|
OMEPRAZOLE
LANOSPRAZOLE RABEPRAZOLE INTERACTION |
ANTIFUNGALS NEED ACIDIC
DO NOT USE WITH ANTIFUNGALS |
|
|
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BB AND PSORIASIS
|
INCREASE PSORIASIS
|
|
|
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IF USE RETINOID ACITRETIN WITH UVA
|
DECREASE UVA 50%
|
|
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ASEPTIC NECROSIS STEROIDS WHEN
|
2- 3 MTHS
|
|
|
|
PUD STEROIDS WHEN MEDICATION
|
> 1 GM
GASTIC > DUDODENAL |
|
|
|
MYOPATHY STEROIDS
|
INCREASE WITH RAPID TAPER
|
|
|
|
ITRACONAZOLE AND DIGOXIN
|
INTRACONAZOLE INHIBIT P-GLCOPROTEIN MEMBRANE PUMP
INCREASE DIGOXIN |
|
|
|
FLUCONAZOLE AND PHENYTOIN
|
INCREASE PHENYTOIN
2C9 FLUCONAZOLE ALSO INHIBITS 3A4 AT < 200 MG |
|
|
|
GROUP B STEROIDS
AND WHAT TO USE WHEN PATCH TESTING |
1. DESONIDE
2. AMCINONIDE 3. FLUCINOLONE 4. HALCINONIDE 5. TAC BUDESONIDE |
|
|
|
GROUP A STEROIDS
AND WHAT TO USE WHEN PATCH TEST |
HC
HC ACETATE TIXOCOTOL |
|
|
|
GROUP D STEROIDS AND WHAT TO USE WHEN PATCH TEST
|
1. BETAMETHASONE VALERATE AND DIPROIONATE
2. PREDNICARBATE 3. HC 17 VALERATE 4. ALCOMETASONE DIPROPIONATE 5. CLOBETASOL 17- PROPRIONATE HC 17 BUTYRATE |
|
|
|
CCB AND AZOLES
|
INCREASE CCB
3A4 LE EDEMA AND HYPOTENSION |
|
|
|
PIMECROLIMUS AND TACROLIMUS BIND TO ?
BLOCKS DEPHOS cNF-AT |
MACROPHILLIN
|
|
|
|
ABACAVIR
|
FEVER MC > RASH
NO PREDNISONE INCREASE CD8 APC |
|
|
|
IVERMECTIN SE
|
ATAXIA AND SEIZURES
|
|
|
|
MEDIAN NAIL DYSTROPHY MEICATION
|
ISOTRETINOIN
|
|
|
|
RITONOVIR
|
TX PML
|
|
|
|
ERLOTINIB
|
HAIR DEPIG
TK C-KIT CLASS 3 TK |
|
|
|
SORAFENIB
|
RENAL AND LIVER
MULTIKINASE INHIBITOR VEGF 2,3, PDGF, TK3, C-KIT 2-3 WKS HAND AND FOOT |
|
|
|
LP DRUG
|
REMICADE
ENBREL HUMIRA LENERCEPT 2 MTHS |
|
|
|
DS DNA
|
RIM/PERIPHERAL
SLE |
|
|
|
NUCLEAR LAMINS
|
RIM/PERIPHERAL
LINEAR MORPHEA |
|
|
|
NUCLEAR PORE
|
RIM/PERIPHERAL
POLYMYOSITIS |
|
|
|
HISTONES/NUCLEOPROTEINS
|
HOMOGENOUS
DRUG SLE SLE |
|
|
|
FIBRILLIN
|
NUCLEOLAR
SYSTEMIC SCLEROSIS |
|
|
|
PM-SCL
|
NUCLEOLAR
SYSTEMIC SLCEROSIS DM POLYMYOSITIS |
|
|
|
RNA-POLYMERASE I
|
NUCLEOLAR
SYSTEMIC SCLEROSIS |
|
|
|
KINETOCHORE PROTEINS CENP A, B, C
|
CETNROMERIC
CREST |
|
|
|
U-RIBONUCLEOPROTEINS U1RNP, SM
|
SPECKLED/PARTIC
SJOGRENS |
|
|
|
U1RNP
|
RIBONUCLEOPROTEINS
|
|
|
|
SN
|
RIBONUCLEOPROTEINS
|
|
|
|
SPECKLED/PARTICLUATE
|
U-RIBONUCLEOPROTEINS
U1 RNP SM MCTD, SLE |
|
|
|
HY-RIBONUCLEOPROTEINS
RO AND LA |
SPECKLED/PARTICLE
SJROGENS SCLE NEONTATAL |
|
|
|
DNA TOPOISOMERASE
|
SPECKLED/PARTICULATE
LE CONGENTIAL HEART BLOCK C2/C4 DEF SYSTEMIC SCLEROSIS |
|
|
|
SCLE HLA
|
A1, B8, DW3
|
|
|
|
SCLE DIF
|
50% LESIONAL AND 30% NON-LESIONAL
|
|
|
|
LINEAR IGA AG
|
120 KD PROTEOLYTIC FRAGMENT OF BP AG2
|
|
|
|
SYMLEPHARON
|
BULBAR AND TARSAL CONJUNCTIVAL
CICATRICIAL PEMPHIGOID EBA |
|
|
|
HLA HG
|
B8, DR3, DR4
|
|
|
|
DEJ SEAPRATION CAUSED BY ? MASTOCYTOSIS
|
MAST CELL CHYMASE
|
|
|
|
PCT DIF
|
BV > DEJ IGG, IGA, IGM
|
|
|
|
HEPATIC PROPHYRIAS DIF
|
NEGATIVE
|
|
|
|
PATIENT WITH SEVERE SULFA ALLERGY AND TOPICAL SILVER SULFADIAZINE
|
TEN
|
|
|
|
SLE AND DISCOID LESIONS BETTER OR WORSE PROGNOSIS THAN SLE WITHOUT DISCOID LESIONS?
|
BETTER WITH DISCOID
|
|
|
|
DAPSONE KIDS
|
HYPERSPLENISM
NO CONTACT SPORTS |
|
|
|
EED TX
|
DIAMINO-DIPHENYL SULFONE
SULFONES OR SULFAPYRIDINE |
|
|
|
EED SENSITIVITY TO INTRADERMAL
|
STERPTOKINASE/STREPTODORNASE
|
|
|
|
REVERENT MOSAISSIM
|
REEXPRESSION OF TYPE 7 COLLAGEN NON-HERLIZT JEB
TYROSEMIA TYPE I BLOOM FANCONI WAS SCID ADNESINE DEAMINSE DOWLING-MEARA EBS |
|
|
|
PSORIASIS SUBEPIDERMAL BULLOUS DISEASE AG
|
LANININ GAMMA1
SALT SPLIT DERMAL SIDE 200 KDA |
|
|
|
SCHEDULED DNA AND NON-SCHEDULED DNA SYNTHESIS
DURING WHAT PHASE OF CELL CYCLE? DEFECT IN XP? |
SCHEDULED DNA SYNTHESIS S PHASE
UNSCHEDULED NON-S PHASE XP DECREASE NON-SCHEDULED |
|
|
|
XP
|
NER
|
|
|
|
TURCOT'S SYNDROME
|
FAMILIAL ADEMAMTOUS POLYPOSIS AND CNS TUMORS
|
|
|
|
TX ACITREIN CUTANEOUS FINDING
|
XANTHOMAS
|
|
|
|
NF2 SCHAWANNOMA TX
|
BEVACIZUMAB
VEGF |
|
|
|
BENZOPHENOES
|
UVA
|
|
|
|
CETIRIZINE AND HYDROXYZINE CROSS REACT WITH
|
ETHYLENEDIAMINE
|
|
|
|
SCLEROMYXEDEMA TX
|
IVIG
|
|
|
|
NALMEFENE
NALOXONE NALTREXONE |
OPIOD RECEPTOR ANTAGONISTS
PRURITUS TREATMENT |
|
|
|
N-METHYL-D-ASPARATE RECEPTOR
|
NMDA RECEPTOR
CNS LUPUS |
|
|
|
ANTI RO
|
SKIN, KIDNEY, HEART
|
|
|
|
BENZOPHENOES
|
UVA
|
|
|
|
ECZEMA HERPETICUM NEW TX
|
HELICASE PRIMASE INHIBTORS
|
|
|
|
NEONATAL LE WITH U1RNP +
|
NO SYSTEMIC SX
NO HLA DR3 C2 RO+ |
|
|
|
MO
|
SLE
|
|
|
|
GUM HYPERTROPHY DRUGS
|
ESTROGEN AND PROGESTERONE
PRIMIDONE NEFEDIPINE |
|
|
|
RECURRENCE DYSPLASTIC NEVUS
|
4%
|
|
|
|
ATOPIC DERMATITIS AND
|
PSORIASIS
|
|
|
|
REEDS RENAL
|
PAPILLARY RENAL CELL CARCIONOMA
|
|
|
|
P53 WHERE IN SCC
|
NUCLEUS
|
|
|
|
OPKT6
|
LANGERHANS
|
|
|
|
BHD RENAL
|
CHROMOPHOBE AND ONCOCYTOMA
COLON POLYPS |
|
|
|
DRUGS FLUSHING
|
DOXORUBICIN
MITHRAMYCIN DECARBAZINE CISPLATIN INTERFERON ALPHA 2 |
|
|
|
CICATRICIAL PEMPHIGOID LAMININ MC MAL
|
VISCERAL ADENOCARCINOMA
|
|
|
|
SCURVY DEFECT
|
LYSYL HYDROXYLASE
NEED O2, FE, ASCORBIC ACID, ALPHA KEOTGLUTARATE |
|
|
|
DOPAMIN BETA HYDROXYLASE REQUIRES
|
CU
|
|
|
|
LYSYL OXIDASE REQUIRES
|
CU O2
|
|
|
|
HYDROXYLYSYL GALACTOTRANSFERASE REQUIRES
|
MN udp-GALACTOSE
|
|
|
|
GALACTOSYLHYDROXYLYSYL TRANSFERASE
|
MN+2, upp GLUCOSE
|
|
|
|
PF ABS
|
IGG4
|
|
|
|
HMB 45
|
ACTIVATED MELANOCYTES
|
|
|
|
INDINAVIR INCREASE WHAT INFECITON
|
ZOSTER
INCREASE CD8+ ALSO OTHER PROTEASE INHIBITORS |
|
|
|
FILARIASIS MC MOSQUITO
|
CULEX FATIGANS
|
|
|
|
EBA HLA
|
DR2
|
|
|
|
EBA INCREASE
|
IBD
|
|
|
|
EN DRUGS
|
SULFA, PCN, BCP
|
|
|
|
BP NEED
|
MMP 9 AND GELATINASE
|
|
|
|
BP BLISTER CYTOKINES
|
IL-4 AND IL-13
|
|
|
|
BP ORAL LESIONS SYMTOMATIC
IF A LOT THEN OTHER DX |
BP ORAL LESIONS ASYMPTOMATIC
EBA IF INCREASE ORAL |
|
|
|
BP DRUGS
|
LASIX
PHENACETIN ENALAPRIL IBUPROFEN AMOXICILLIN, AMPICILLIN, PCN BB SPRIONOLACTONE BUEMTANIDE PROZAC PENICILLAMINE FLU VACCINATIONS UV LIGHT UVB, PUVA |
|
|
|
C1 INHIBITOR
|
SERPIN OF SERINE RPOTEASE
INHIBIT COMPLEMENT PROTEASES, KALLIUERIN, COAGULATION 11A AND 12A PLASMIN |
|
|
|
17 ALPHA ALKYLATED ANDROGENS
|
HEREDITARY ANGIOEDEMA TX
|
|
|
|
HEREDITARY ANGIOEDEMA INCREASE
|
GLOMERULONEPTHRITIS
|
|
|
|
ACQUIRED ANGIOEDEMA
|
GAIN FX COAG FACTOR 12 INCREASE BRADYKININ
|
|
|
|
MORPHEA +ANA
|
40%
|
|
|
|
DUCSSELDORF CLASSIFICATION
|
LUPUS
|
|
|
|
LINEAR IGA HLA
|
B8
|
|
|
|
LAMINA LUCIDA
|
LAMININ 1, 5
UNECIN BPAG2 FIBRONECTIN FETAL SKIN |
|
|
|
LAMINA DESNA
|
COLLAGEN 4
HEPARIN SULFATE CHONDROTIN 6 SULFATE NIDOGEN/ENTACIN TYPE 7 COLLAGEN |
|
|
|
SUPRABASAL EBS
|
LETHAL ACANTHYOLYTIC DEFECT DESMOPLAKIN
PLAKOPHILIN-1 DEF EBS SUPERFICIALIS |
|
|
|
BASAL EBS
|
EBS AR K14
EBS OGNA PLECTIN EBS MIGRATORY CIRCINATE K5 |
|
|
|
EBS MIGRATORY CIRCINATE
|
BASAL EBS
KERATIN 5 |
|
|
|
JEB INVERSA
|
LAMININ 5
|
|
|
|
LOC SYNDROME
|
LAMININ 5 ALPHA 3 CHAIN
DENTAL ENAMEL INCREASE CA+2 |
|
|
|
DIF LUPUS FACE
|
HISTO > DIF
|
|
|
|
PV ACANTHOLYSIS
|
INCREASE INTRACELLULAR CA
IOSITOL 1,4,5 TRIPHOSPHATE PK C PHOS DSG 3 AND P38 MITOGEN ACTIVATED PROTEIN KINASE PLAKOGLOBIN |
|
|
|
DAPSONE
|
SULFONE
|
|
|
|
ANTIPHOSPHOLIPID
|
PRTHROMBIN ACTIVATOR COMPLEX 10A, 5, PHOSPHOLIPID
INCREASE TROMBOPLASTIN |
|
|
|
MOA botulinum toxin A
|
light chain cleaves SNAP-25
|
|
|
|
Heavy and light chain of botulinum toxin A
|
heavy chain binds to nerve membrane and it endocytosed into a vesicle with the light chain
light chain cleaves SNAP-25 |
|
|
|
potassium-titanyl phosphate
|
KTP 532
|
|
|
|
Nd-YAG grequency doubled
|
532
|
|
|
|
Ruby
|
694
|
|
|
|
Nd-Yag long pulsed
|
1320
|
|
|
|
Erbium Yag (pulsed)
|
2940
|
|
|
|
IPL
|
512 to 200
hair removal |
|
|
|
Longest acting filler
|
polymethylmethacryate
Artefill 5 yrs |
|
|
|
Poly-L-lactic acid
|
sculptra
|
|
|
|
ETIDOCAINE
|
200 W/O EPI
300 W EPI |
|
|
|
PRILOCAINE
|
30-120 W EPI
60-400 W/O EPI |
|
|
|
LIDOCAINE
|
30-130 W/O EPI
60-400 W EPI |
|
|
|
BUPIVICAINE
|
SLOW ONSET
130-240 W/O EPI 240-480 W EPI |
|
|
|
TETRACAINE
|
SLOW ONSET
120-240 W/O EPI 240-480 W EPI |
|
|
|
PROCAINE
|
15-30 W/O EPI
30-90 W EPI |
|
|
|
LEIOMYOSARCOMA TYPE
|
CUTANEOUS: ARRECTOR PILI
SC: VASCULAR LOCAL RECURRENCE 30-50% |
|
|
|
SEBACEOUS CARCINOMA GLAND OF EYE
|
MEIBOMIAN GLAND
|
|
|
|
SEBACEOUS CARCINOMA CLINICAL
|
PANILESS NODULE UPPER > LOWER EYELID
ASIAN FEMAL AGRESSIVE 30% RECURRENCE METS 30% |
|
|
|
GREASTEST KNOT SECURITY
|
SILK = LOW MEMORY
|
|
|
|
LIDOCAINE TOXICITY
|
1-5: ANXIETY, CIRCUMORAL, TINNITUS, DOUBLE VISION, STOMPACH UPSET
5-8 UG/ML MUSCLE TWITCHING, TREMOR 8-12 SEIZURES CARDIAC ARREST |
|
|
|
SENSORY ALA
|
INFRAORBITAL NERVE V2
|
|
|
|
V2
|
MAXILLARY NERVE
|
|
|
|
ZYGOMATICOFACIAL NERVE
|
V2
MALAR EMINENCE |
|
|
|
INFERIOR ALVEOLAR NERVE
|
MANDIBULAR TEETH, LOWER LIP, AND CHIN
V3 |
|
|
|
V2 BRANCHES
|
INFRAORBITAL
ZYGOMATICOFACIAL ZYGOMATICOTERMORAL |
|
|
|
INFRAORBITAL INNERVATES
|
MEDIAL CHEEK
UPPER LIP LOWER EYELID LATERAL NOSE ALA |
|
|
|
MERKEL CELL VIRUS
|
POLYOMA VIRUS
|
|
|
|
RISK FACTORS FOR MERKEL CELL
|
ORGAN TRANSPLANT
HIV CLL MORE AGGRESSIVE |
|
|
|
ANGIOSARCOMA WORSE PROGNOSIS
|
> 5 CM
METS TO NODES, LUNG,LIVER, SPLEEN |
|
|
|
POLYGLICAPRONE
|
MONOCRYL
|
|
|
|
DEXON
|
POLYGLYCOLIC ACID
|
|
|
|
PDS %
|
70% 14 DAYS
50% 28 DAYS |
|
|
|
MEDIUM THICKNESS SKIN GRAFT
|
0.012 TO 0.18 INCHES
|
|
|
|
SKIN GRAFTS
THIN MEDIUM THICK |
THIN .008
MEDIUM 0.012 THICK 0.018-0.030 |
|
|
|
REIGER FLAP
|
DORSAL NASAL ROTATION FLAP
|
|
|
|
MARGINAL MANDIBULAR NERVE FUNCTION
|
INMPAIRMENT CAN'T MOVE LIP DOWN
|
|
|
|
MERKEL LOCATION
|
HEAD AND NECK
LE TRUNK |
|
|
|
HEMATOMA STAGES
|
AMPORHOUS
ORGANIZED: OBSERVE LIQUIFIED: ASPIRATE RESORPTION |
|
|
|
POSTERIOR ANKLE INNERVATION
|
SURAL NERVE
|
|
|
|
SURAL NERVE INBETWEEN
|
LATERAL MALLELOUS AND ACHILLES
|
|
|
|
POSTERIOR TIBIAL NERVE BLOCK
|
POSTERIOR AND LATERAL
MEDIAL MALLELOUS |
|
|
|
SURAL NERVE BRANCH OF
|
COMMON FIBULAR AND TIBIAL NERVE
|
|
|
|
TENSION VECTOR
|
SUMMATION OF ALL FORCES OF CLOSURE EXPRESSED AT A SINGLE POINT
ONE SINGLE ARROW |
|
|
|
PDT FDA
|
NONHYPERTROPHIC AKS HEAD AND SCLAP
|
|
|
|
VICRYL
|
POLYGLACTIN 910
|
|
|
|
POLYGLYCOLIC ACID
|
ABSORBABLE
BRAIDED LOW REACTIVITY GOOD KNOT SECURITY 60-90 DAYS |
|
|
|
BASAL CELL NEVUS MAJOR CRITERIA
|
BCCS
JAW CYSTS PITTING FALX CEREBRI FXH BCNS |
|
|
|
BASAL CELL NEVUS MINOR CRITERAI
|
CRANIOFACIAL
BIFID MEDULLOBLASTOMAS CARDIAC OR OVARIAN FIBROMAS LYMPHOMESENTERIC CYSTS CLEFT LIP, POLYDACTYLY, EYS |
|
|
|
VERRUCOUS CARCIONMA HPV
|
6,11
|
|
|
|
LANGERHANS CELL HISTIOCYTOSIS
|
CD34 NEG
MS-1 NEG |
|
|
|
MS-1
|
SINUSOIDAL ENDOTEHLIAL CELL ND DENDRITIC PERVIASCULAR MO
NON-LANGERHANS CELL HISTIOCYTOSES |
|
|
|
LANGERHANS CELL HISTIOCYTSOSIS CLINICAL
|
EXTERNAL AND MIDDLE EAR
MASTOID X RAY ORAL PERIODONTAL INFLAMMATION GUMS LOSS OF TEETH GH DEF |
|
|
|
CONGENITAL SELF-HEALING RETICULOHISTOCYTOSIS
|
LOOKS LIKE HEALING VERICELLA
NO SYSTEMIC EM VIRBECK GRANULES AND DENSE BODIES IN HISTIOCYTES |
|
|
|
DESANCTIS CACCHIONE SYNDROME
|
GROUP A XP
SKIN ANC CNS JAPAN CHROMO 9 |
|
|
|
XP GROUP C
|
ONLY SKIN
NO CNS CHORMO 3 |
|
|
|
GROUP D XP
|
EXCISON REPARI 25-50% NORMAL
CHROMO 19 |
|
|
|
MOST SEVERE XP
|
GROUP A
CHROMO 9 |
|
|
|
GROUP E XP
|
ONLY FEW SKIN CANCERS
40-50% NL CHROMO 11 |
|
|
|
GROUP F XP
|
MILD SKIN SYMTPMOS
EXCISION REPAIR 10 - 20% CHROMO 16 ERCC4 |
|
|
|
ERCC
|
XP F
|
|
|
|
GROUP G XP
|
MR
NEURO PHOTO EXCISION REPAIR < 5% CHROMO 13 ERCC5 |
|
|
|
ERCC5
|
XP G
|
|
|
|
VARIANT XP
|
MILD TO SEVERE SKIN
CNS NL POST-REPLICATION REPAIR |
|
|
|
MCCUEN ALBRIGHT
|
CHROMO 20
|
|
|
|
CALMS
|
TYROSINASE
|
|
|
|
OSTEOMA CUTIS CHILD LABS
|
CA,PHO, PTH, THRYOID
ALBRIGHT HEREDITARY OSTEODYSTROPHY |
|
|
|
KNUCLE SIGN
|
SHORT 4TH AND 5TH METACARPALS
|
|
|
|
ALBRIGHT HEREDITARY OSTEODYSTROPHY BRAIN
|
CALCIFICATION BASAL GANGLIA
|
|
|
|
IP 80% OF NEW NEMO MUTATIONS PATERNAL OR MATERNAL
|
80% OF NEW MUTATIONS NEMO PATERNAL
|
|
|
|
NEONATAL HERPES
|
PREMATURE 24%
30% CNS ONLY 50% DISSEMINATED 18% SKIN ,YE, MOUTH ONLY SKIN LESIONS 70% |
|
|
|
ATP7A, MNK
|
UC TRANSPORTIN ATPASE
|
|
|
|
MENKES
|
XLR
LOW CU AND CERULOPLASMIN PROGRESSIVE NEURO, EIZURES, CEREBLLAR BONE OSTEOPOROSIS, SCALLOPED VERTEBRAE, METAPHYSAL SPURRING, WORMIAN SKULL BONES BLADDER DIVERTICULI |
|
|
|
APLASIA CUTIS CONGENITA TYPES
|
1: SCALP AD, SPORADIC NO ABNL
2. SCALP AND LIMB, CMTC, WOLLY HAIR,SUPERMAMMARY NIPPLES 3. EPI AND SEBACOUS NEVUS 4. UNDERLYING EMBRYO 5. PAPYRACEOUS PLACENTA 6. EB 7. EXTREMITIES 8 TETROGENS METHIMAZOLE 9. OTHER DISEASE |
|
|
|
TYPE 9 APLASIA CUTIS CONGENITA
|
OTHER ABNL
1. PATAU SYNDROME 13 2. WOLF-HIRSHCHHORN BIG MIDLINE SCALP 3. SETLEIS SYNDROME BITEMPROAL 4. JOHANSON-BLIZZARD: PANCREAS, SCALP 5. GOLTX 6. AMNIOTIC BLAND DISRUPTION 7. OCULOCEREBROCUTANEOUS (DELLEMAN) SYNDROME SCALP-EAR-NIPLLE SYNDROME (FINLAY-MARK) KABUKI SYNDROME 46XY GONADAL DYSGENESIS |
|
|
|
RETICULOLINEAR APLASIA CUTIS CONGENITA ON FACE AND NECK
|
Xp22
|
|
|
|
adams oliver syndrome
|
APC TYPE 2
AD ACC LIMB +/- CUTIS MARMORATA |
|
|
|
ILVEN ONSET
|
< 5 YO
|
|
|
|
ZOSTER KIDS
|
ALL
ALSO AFTER VACCINE |
|
|
|
DOWN'S MC
|
AA
CUTIS MARMORATA VITILIGO SOFT VELVETYS SKIN ACROCYANOSIS |
|
|
|
MASTOCYTOSIS AVOID
|
OPIATES: CODEINE
POLYMYXIN B SULFATE CONTRAST DYE ASA |
|
|
|
CYPROHEPTADINE HYDROCHLORIDE
|
PERIACTIN
ANTIHISTAMINE ANTISEROTONIN |
|
|
|
CHILDHOOD SPORIASIS CLINICAL
|
ITCHY FACE
UNCOMMON < 10% FAMILY MEMBER |
|
|
|
KASABACH MERRITT SYNDROME
|
INFANTS 6 WKS
TX PREDNISONE, ALPHA INTERFERON |
|
|
|
NF MALIGNANCIES
|
RHABDOMYOSARCOMA
MALIGNANT SCHWANNOMAS WILMS MENINGIOMA OPTIC GLIOMA |
|
|
|
MC NF 1 BRAIN TUMOR
|
OPTIC GLIOMA
NON-PROGRESSIVE |
|
|
|
NF 1 ENDO
|
HYPERPTH
ADDISON DISEASE |
|
|
|
MEDULLOBLASTOMA
|
BCNS
|
|
|
|
CARDIAC RHABDOMYOMAS
|
TS
|
|
|
|
TS BONES
|
PHALANGEAL CYSTS, PERIOSTEAL THICKENING
|
|
|
|
HAMARTIN FUNCTION
|
TUMOR SUPPERSOR GENE
|
|
|
|
TUBERIN FUNCTION
|
GAP PROTEIN
|
|
|
|
PROTEUS SKIN
|
EPIDERMAL NEVI
CALMS MACULAR HYPER OR HYPOPIG LINEAR OR WHORLED CONNECTIVE TISSUE NEVI |
|
|
|
EPIBULBAR TUMORS
|
PROTEUS
|
|
|
|
PROTEUS MALIGNANCY
|
TESTICULAR TUMORS
|
|
|
|
PROTEUS
|
MOSAICISM
|
|
|
|
ZINSSER COLE ENGMAN SYNDROME
|
DYSKERATOSIS CONGEITA
NAIL DYSTROPHY AFTER 5 YO BULLAE ORAL, ANAL, EOSPHAGEAL, URETHRAL MUCOSASE DX 10 YO |
|
|
|
DYSKERATOSIS CONGENITA MAILGANCIES
|
ADENOCARCINOMA
SISTER CHROMATID EXCHANGES SCC ORAL LEUKOPLAKIA |
|
|
|
NOLA3
|
AR DYSKERATOSIS CONGENITA
|
|
|
|
TERC
|
AD DYSKERATOSIS CONGENITA
|
|
|
|
CYSTIC FIBROSIS SKIN
|
AE LIKE ERUPTION
DECREASE ZN EDEMA |
|
|
|
DIFFUSE NEONATAL HEMANGIOMATOSIS IMAGING LIVER AND BRAIN LESIONS MRI OR US
|
US OR CT
LIVER OR BRAIN > GI |
|
|
|
DIFFUSE NEONATAL HEMANGIOMATOSIS COMPLICATIONS
|
HIGH OUTPUT CARDIAC FAILURE
GI BLEEDING HYDROCEPHALUS CONSUMPTIVE COAGULOPATHY |
|
|
|
XL ICHTHYOSIS ONSET
|
3 YO
WORSE IN WINTER |
|
|
|
ANAPHYLACTOID PURPURA
|
HSP
|
|
|
|
HSP CS AFFECT
|
NO AFFECT ON PURPURA OR NEPHRITIS
|
|
|
|
HSP IGA
|
IN DERMAL VESSELS AND IN BLOOD
|
|
|
|
HEAD AND NECK LARGE CONGENTIAL NEVUS ASSOCIATED WITH
|
EEG ABNL
|
|
|
|
MEN 2B MORTLAITY
|
HIGH RISK OF THRYOID CANCER
MORTALITY 20 -30 |
|
|
|
MEN 2B
|
BILATERAL PHEO
MARFANOID KYPHOSCOLIOSIS CHROMO 10 |
|
|
|
RET ONCOGENE
|
CHROMO 10
|
|
|
|
MULTIPLE PTERYGIUM SYNDROME
|
WEBS AND CONTRACUTES JOINTS KNEES FROM BIRTH
|
|
|
|
EVERTED EYELID SIGN
|
MEN2B
|
|
|
|
ATM
|
CHROM 11
|
|
|
|
klein waardenburgy syndrome
|
type 3
pax3 |
|
|
|
Waardenburgy Shah Syndrome
|
Type 4
SOX10 or EDN3 Endothelin B receptor |
|
|
|
EPIDERMAL NEVUS SYNDROME
|
EPIDERMAL NEVI
HYPOPIG CALMS MULTIPLE SKELETAL DEFECTS KYPHOSCOLIOSIS VERTEBRAL DEFECTS HEMIHYPERTROPHY SHORT LIMBS PHOCOMELIA FEGFR3 RECEPTOR |
|
|
|
TRPS1
|
HAPLO INSUFFICIENCY OF SPECIFIC ZINC FINGER PROTEIN
TRANSCRIPTION FACTOR |
|
|
|
TRICHORHINOPHALANGEAL SYNDROME I AND 2
|
TYPE 1: TRSP1 ZINC FINGER TRANSCRIPTION FACTOR
TYPE 2: LANGER-GIEDION MULTIPLE EXOSTOSES, LOOS SKIN INFANCY, HYPEREXTENSIVEL JOINDS, LGCR GENE |
|
|
|
LANGER-GIEDION SYNDROM
|
TYPE 2 TRICHORHINOPHALANGEAL SYNDROME
INCREASE NEVI HYPEREXTENSIBLE JOINDS LGCR GENE |
|
|
|
TRICHORHINOPHALANGEAL TYPE 3
|
SUGIO KAJII YSNDROME
BRACHYDACTYLY SHORT TRPS1 GENE |
|
|
|
TMPT CHROMOSOME
|
6
|
|
|
|
PHEO DIAGNOSIS
|
24 HOUR URINE METANEPHRINE AND NORMETAEPHRINE
|
|
|
|
PHEO SURGERY
|
NEED ALPHA THEN BETA BLOCKERS
|
|
|
|
UV MAX ABSORPTION
|
245-290
CYCLOBUTANE PRYIMIDINE DIMERS |
|
|
|
UV MMP
|
MMP1
|
|
|
|
GENISTEIN
|
PREVENTS C-JUN UPREGULATION AND COLLAGENASE IN UV EXPOSURE
|
|
|
|
TEA POLYPHENOLS
|
INHIBIT UV INDUCED EXPRESSION OF MMP
|
|
|
|
COX2
|
CELECOXIB
DECREAE P53 ACTIVATION AND DNA DAMAGE IN UV EXPOSED SKIN |
|
|
|
DIFLUROMETHYLORNITHINE (dfmo)
|
IRREVERSIBLY INHIBITS ORNITHINE DECARBOLXYLASE
|
|
|
|
ACQUIRED ICTHYOSIS ASSOCIATED MALIGNANCY
|
HODGKIN'S LYMPHOMA
|
|
|
|
INTRACELLULAR CORPUSCLES OF GAMMA-MIYAGAGAWA
|
LGV
|
|
|
|
PLAGUE TREATMENT
|
STREPTOMYCIN
GETNAMYCIN, TETRACYCLINE, CHORAMPHENICOL |
|
|
|
HAART LOWER HD OR NHL
|
ONLY LOWER NHL
HIV + INCREASE HD 10X HAART DOES NOT IMPROVE SURVIVAL |
|
|
|
PSEDUO CTCL
|
HIV
HISTOLOGY DOESN'T HELP DIFFERENTIATE |
|
|
|
HIV INCREASE NMSC
|
BCC > SCC
|
|
|
|
HHV8 TYPE OF VIRUS
|
RHADINOVIRUS
|
|
|
|
KAPOSIS CELL TYPE
|
PLASMA CELLS
|
|
|
|
KAPOSIS TX
|
LIPOSOMAL DOXYORUBICIN OR DAUNORUBICIN
PACLITAXEL GANGCICLOVIR |
|
|
|
PROTEASE INHIBITORS BLOCK
|
FGF
|
|
|
|
TOPICAL STEROIDS INCREASE
|
VELLUS HAIR GROWTH
|
|
|
|
INCREASES POTENCY STEROID
|
HALOGENATION AT 9 ALPHA CARBON
|
|
|
|
INCREASES LIPOPHILICITY AND PENETRATION STEROIDS
|
REMOVE 17-HYDROXOACETONE SIDE CHAIN
|
|
|
|
LOBOMYCOSIS LOCATION
|
AMAZON
BASIN |
|
|
|
RHINOSPORIDIOSIS
|
SRI LANKA
NORTHERN BRAZIL DUST OR WATER EXCISION AND IL AMPHO |
|
|
|
CHROMO
|
SUBTROPICAL
AFRICA ASIA AMERICA |
|
|
|
MYCETOMA FUNGAL AND BACTERIAL TX
|
EUMYCETOMA: AZOLE AND SURGERY
ACTINOMYCETOMA: STREPTOMYCIN AND DAPSONE |
|
|
|
SPOROTRICHOSIS TX
|
ITRACONAZOLE, SSKI, AMPHO B
|
|
|
|
PENICILLOSIS MARNEFFEI
|
SOUTHEAST ASAI
INHALATION UMBILICATED PAPULES WITH CENTRAL NECROSIS ITRACONAZOLE +/- AMPHO B |
|
|
|
NUCLEIC ACID TARGET AMPLIFICATION
|
MC NAT DIAGNOSTI CMETHOD
USING POLYMERASE OR LIGASE TO MULTIPLY GENETIC MATERIAL |
|
|
|
ISOTHERMAL
|
PCR AND LCR REQUIRE MULTIPLE TEMPERATURES
|
|
|
|
LYME PCR
|
SURFACE PRTOEIN A
|
|
|
|
ESTROGEN RECEPTORS
|
ALPHA: SKIN > SCALP
BETA: OVARY, MALE ORGANS, HYPOTHALAMUS, CORTEX, SKIN ESP SCALP AND FOLLICLES |
|
|
|
KO ESTROGEN RECEPTORS
|
ALPHA AND BETA
|
|
|
|
ESTRADIOL FIBROBLASTS
|
INDUCES PROLIFERATION
INHIBITS MMPS |
|
|
|
ESTROGEN RECEPTORS AND MELASMA
|
NUCLEAR RECEPTOR FAMILY
|
|
|
|
MAST CELL VS KININ AE
|
MAST CELL URTICARIA, NSAIDS, INFECTION, EPISODIC, URTICARIAL VASCULITIS
KININ ANGIOEDEMA |
|
|
|
RA ASSOC WIH
|
PYODERMA GANGRENOSUM AND GRANULOMATOUS DERMATITIS
|
|
|
|
HLA PROTECTIVE RA
|
DRW2
DRW3 BAD |
|
|
|
ACCELERATED RA NODULES
|
MTX, ENBREL
|
|
|
|
RA ASSOC
|
FELTY SYNDROME
|
|
|
|
PRIMARY UVB CHROMOPHORES
|
PYRIMIDINE
PURINE,TYRPTOPHA, TYROSINE |
|
|
|
PRIMARY UVA CHROMOPHORES
|
NADH
VLAVINS UNSAT LIPIDS |
|
|
|
UROCANIC ACID PEAK ABSORPTION
|
277 NM
|
|
|
|
MELANIN ABSORPTION INCREASES WITH INCREASING OR DECREASING WAVELENGTH
|
DECREASING
UVB |
|
|
|
BRESLOW COMBINED WITH ? VERY PREDICTIVE
|
KI-67
|
|
|
|
CYCLIN D3
|
>5% NEGATIVE PROGNOSTIC FACTOR
|
|
|
|
MMP-2
|
MELANOMA METASTASES BUT NOT THICNESS
POOR PROGNOSIS ESP MALES |
|
|
|
INCREASING DNA INDEX ANEUPLOIDY PREDICTS ? MELANOMA
|
DECREASED DISEASE FREE SURVIVAL
|
|
|
|
TOPOISOMERASE 2A
|
INCREASE MELANOMA
|
|
|
|
ANTIMICROBIAL PEPTIDE PLAYS A ROLE IN FIGTHING LEPROSY
|
GRANULYSIN IN T CELLS
|
|
|
|
LL-37
|
AGAINST STAPH
|
|
|
|
HBD-2 INCREASES
|
WTH INFLAMMATION
|
|
|
|
HBD-2 BINDS TO
|
CCR-6 ACTIVATES MO, DEGRANULATES MASTOCYTES, ACTIVATES TLR-4
|
|
|
|
ALPHA-DEFENISN 1-4
|
HUMAN NEUTORPHIL PEPTIDE
INCREASE TNF-A ANTIVIRAL 5,6 OPANETH CELLS OF SMALL INTESTIN |
|
|
|
GRANULYSIN
|
EXPRESSED ONLY BY HEMATOPOETIC CELLS
FAMILYNAKTRUAL KILLER LYSINE APOPTOSIS LEPROSY |
|
|
|
PSORIATIC ARTHRITIS ASSOC WITH
|
TNF PROMOTER MUTATIONS AND PSORS2 HLA REGION
|
|
|
|
PSORIATIC ARTHRITIS HLA
|
HLA-B27 AXIAL
B17 CW26 DR4 DR7 |
|
|
|
PSORIATIC ARTHRITIS WORSE PROGNOSIS
|
ESR > 15
FEMALE NO NAIL LESIONS HLA-B39, B27 WITH DR7 |
|
|
|
BACTRAM HAPTEN
|
SMX-NITROSO
|
|
|
|
ALLOPURINOL HAPTON
|
OXYPURINOL
|
|
|
|
DIRECTLY REACT WITH TISSUE NO HAPTEN IN TEN
|
PCN AND CAPTOPRIL
|
|
|
|
CARBAMAZEPINE HAPTEN TEN
|
DIRETLY INTERACTS WITH T CELLS
|
|
|
|
TEN
|
CYTOTOXIC CD56 T CELLS
CASPASE 8 FAS-FASL PERFORIN/GRANZYME CTYOTOXIC T CELLS GANZYME B PROTEASE ACTIVATES CASPASE |
|
|
|
TEN TX
|
HIGH DOSE PUSLECS LOWER MORTLAITY
|
|
|
|
CS OSTEOPOROSIS MOA
|
DECREASE CALCIUM ABSORPTION
SUPPRESS BONE FORMATION OSTEOBLASTS |
|
|
|
MELANOMA DNA MICROASSAYS
INCREASE |
CYCLIN D1, C-MYC BINDING PROTEIN
|
|
|
|
WNT5A
|
CELL MOBILITY
MELANOMA METS |
|
|
|
DNA MICROASSAYS
|
ssDNA TO HYBRIDIZE TO COMPLEMENTARY DNA SEQUENCES
SEQUENCE SPECIFIC IDENTIFICATION OF DNA |
|
|
|
LIEZOLID AGAINST
|
BACTERIOSTATIC
BACTERIACIDA AGAINST CLOSTRIDIUM PERFRINGENS, BACTEROIDES FRAGILIS, SOME STRE PNEMONIAE NON-SELECTIVE REVERSIBLE INHIBITOR OF MO |
|
|
|
QUINUPRISTIN-DALFOPRISTIN
|
2 SEMISYTNETIC PRISTINAMYCIN
VREF BACTEREMIA AND COMPLICATED SKIN INFECTIONS 50S IRREVERSIBLE INHIBITION OF BACTERIAL PROTEIN SYNTHESIS |
|
|
|
DAPTOMYCIN
|
LIPOPEPTIDE ANTIBIOTIC
STREPTOMYCES ROSEOSPORUS G+ BACTERIA MOA UNKNOWN SKELTAL MUSCLE TOXICITY |
|
|
|
quinupristin-dalfopristin
|
2 semisynthetic pristinamycin derivatives
first parenteral streptogramin antibacterial agent FDA VREF bacteremia, SA, strep 50s irreversible inhibition of bacterial protein syntehssi |
|
|
|
daptomycin
|
lipopeptide
strep roseosporus G+ MRSA and VRE MOA unkown skeletal muscle toxicity |
|
|
|
dRYVAX SMALL POX VACCINE CONTRAINDICATIONS
|
ALLERGY TO STREPTOMYCIN, NEOMYCIN, OR POLYMYXIN, CHORTETRACYCLIN HYDROCHLORIDE
|
|
|
|
SOURCE OF IL-10
|
MO
ALSO T CELLS, MONO CYTES, DCS, B CELLS, EOS, MAST CELLS, KO |
|
|
|
MEMBERS OF IL-10 FAMILY
|
IL-19, IL-20, IL-24/MDA-7, IL-22/IL-TIF, IL-26/AK155
|
|
|
|
INCREASE IL-10
|
ENDOTOXIN TLR-4, NF-KB
TNF-VIA TNF P55 RECEPTOR NFKB CATECHOLAMINES CYCLIC ADENOSINE MONOSPHOSHATE ELEVATING DRUGS VIA PK A, CREB1, ATF-1 |
|
|
|
INCREASE IL-10 RECEPTOR ON FIBROLBLASTS
|
ENDOTOXIN
GLUCOCORTICOIDS VITAMIN D3 CALCIPOTRIOL |
|
|
|
DECREASE CAMP
IL-10 |
DECREASE IL-10
|
|
|
|
ILOPROSTOL
|
INCREASE IL-10
PSORIASIS TX |
|
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LATE ONSET FOCAL DERMAL ELASTOSIS
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ASYMPTOMATIC YELLOW PAPULES ON EXTREMITIES
INCREASED NL APPEARING ELSASTIC TISSUE RETICULAR DERMIS |
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LINEAR FOCAL ELASTOSIS
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ASYMPTOMATIC YELLOW OR RED LINEAR PLAQUES
LUMBAR SPINE MASSIVE WAVY FRAGMENTED BASOPHILIC ELASTIC FIBES RETICULAR DERMIS |
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FOCAL DERMAL ELASTOSIS
INCREASE ELASTIC TISSUE RETICULAR DERMIS ASYMPTOMATIC YELLOW PAPULES ON EXTREMITIES |
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LINEAR FOCAL ELASTOSIS
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coarsely clumped elastic fibers in the reticular dermis
MASSIVE WAVY BASOPHILIC FRAGMENTED ELASTIC FIBERS RETICULAR DERMIS ASYMPTOMATIC YELLOW OR RED LINEAR PLAQUES LUMBAR SPINE layered, symmetric, palpable, striae-like, yellow bands of the middle and lower back that extend horizontally and on both sides of the vertebral column. Histologically, deposition of abundant pale-staining material separating collagen bundles is noted. Elastic tissue stain shows that material to be agglutinated elastic tissue and von Kossa's stain is negative. Electron photomicrographs show bits of fragmented elastic fibers. The pathogenesis is unknown. Some authors have postulated that linear focal elastosis may represent hyperplasia of elastic fibers in response to damage, primarily in the setting of concomitant striae distensae. Others have postulated that it may represent a nevoid or hamartomatus condition in which degenerative and regenerative processes are occurring in elastic fibers. |
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Linear focal elastosis is an uncommon dermal elastic disorder, characterized by palpable, linear bands clinically and an increase in abnormal elastic tissue histologically.
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ELASTODERMA
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LOCALIZED AREAS OF PENDULOUS SKIN ON TRUNK AND EXTREMITIES
INCREASE ELSTIC TISSUE PAPILLARY AND SUPERFICIAL RETICULAR DERMIS |
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ELASTOFIBROMA
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JAPANESE PATIENTS
SLOWLY GROWING SC NODULE ADJACENT TO SCAPULA FRAGMENTED ELASTIC FIBERS STUDDED WITH GLOBULAR AGGREGATES OF ELASTIC MATERIAL APPEARING SERRATED |
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ELASTOFIBROMA
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ELASTOFIBROMA
SC NODULE SCAPULA JAPANESE FRAGMENTED ELASTIC FIBERS STUDDED W GLBULAR AGGREGATES OF ELASTIC MATERIAL APPEARING SERRATED |
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EPS
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M>F
ASYMPTOMATIC OR PRURITC PINK SCALY PAPULES AND ARCUATE PLAQUES ON HEAD, TURNK, AND EXTREMITIES INCREASE ELASTIC TISSUE PAPILLARY DERMSI WITH TRANSEPIDERMAL ELIMINATION OF ELASTOTIC FBIERS |
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PXE
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MALES
MIDDLE TO ELDERLY WOMEN EARLIER MID AGE MULTIPAROUS AAS COALESING PAPULES IN ANTECUBITAL FOSSA PERIUMBILICAL FRAGMENTED CURLED THICK ELASTIC FIBERS MID TO DEEP RETICULAR DERMIS |
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ELASTOMA
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BIMODAL TEENS AND OLDER PTS WITH ACTINIC DAMAGE
FIRM, YELLOW PAPULES AND PLAQUES OR NODULES TRUNK INCREASED TORTUOUS ELASTIC FIBERS AND DEPOSITS OF ELASTOTIC MATERIAL IN MID AND DEEP RETICULAR DERMIS |
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ANETODERMA 2 CLINICAL CATEGORIES
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1. SCHWENINGER-BUZZI NO PRECEDING ERYTHEMA
2. JADASSOHN-PELLIZZARI MACULAR ERYTHEMA OR PAPULAR URTICARIA |
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SECONDARY ANETODERMA ASSOC
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THYROID
ADDISON SJOGREN HEP B VACCINATION CHRONIC ANGULAR CHELITIS CONGENTIAL MELANOCYTIC NEVI WITH HAMARTOMATOUS FEATURES JXG GENERALIZED GA |
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TEN POOR PROGNOSIS LAB
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NEUTROPENIA
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BASTUJI-GARI-CLASSIFICATION
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EM, SJS, TEN
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CAPILLARY MALFORMATION AD
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CMC1 GENE ENCODES RASA1 WITH CATIVATES RAS-GAP
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VENOUS MALFORMATIONS RISK OF
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THROMBOSIS
BLUE MASS COMPRESSION LIMITS PAIN |
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GLOMOVENOUS MALFORAMTION
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TYPE OF VM
BLUE PURPLE PEBBLY NODULES 64% FAMILIAL LESS COMPRESSIBLE AND PAINFUL TO PALPATION MUTATION GLOMBULIN COMPRESSION WORSENS PAIN |
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AVM PROGRESSIVE PHASE
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60% AT BIRTH
30z% CHILDHOOOD PROGRESSIVE PHASE TEENS DARKENING AND THICKENING |
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AVM PHASE 3
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DEEP DESTRUCTION
NECROSIS, ULCERATION, PAIN, HEMORRHAGE YEARS AFTER PROGRESSION |
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AVM 4 PHASES
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AVM 4 PHASES
1. QUIESCENT PHASE ASYMPTOMATIC 2. PROGRESSIVE DARKENING AND THICKENING TEENS 3. DEEP DESTRUCTION PHASE NECORSIS, ULCERATION, PAIN, HEMORRAGE 4. CARDIAC DECOMPENSATION |
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SCORTEN
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MORTALITY PREDICTOR
WITHIN 24 HRS OF ONSET AGE > 40 HR > 120 MALIGNANCY EPIDERMAL DETACHEMENT > 10% BUN > 28 GLUCOSE > 252 BICARB < 20 SCORE 4 = 58% MORTALITY SOCRE 5 > 90% MORTALITY |
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LYMPHATIC MALFORMATIONS
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LYMPHEDEMA GENERLAIZED MC
1. MILROYS AD 2. MEIGE 3. LYMHADEMA TARDA |
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DEEP LM
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CYSTIC HYGROMA
PRENATAL US NECK OR AXILLA |
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MICROCYTIC LM
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LIMBS, AXILLAE, CHEST
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SUDDEN ENLARGEMENT OF LYMHATIC MALFORMATION
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BACTEIRAL INFECTION
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CUTIS MARMORATA TELANGIECTATICA CONGENITAL MC EXTRACUTANEOUS ABNL
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LIMB HYPOPLASIA
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THROMBOCYTOPENIA ABSENT RADIUS (TAR)
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AR
HYPOMEGAKARYOCYTIC THROMBOCYTOEPNIA BILATERAL RADIAL APLASIA AND FOREHEAD STAIN ANEMIA, EOSINOPHILIA, LEUKEMOID GRANULOCYTOSIS |
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PHAKOMATOSIS PIGMENTOVASCULARIS
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1. EPI NEVUS
2. MC W MONGOLIAN 3. NEUS SPILUS 4. NEVUS SPILUS AND MONGOLIAN NEVUS ANEMICUS IN 2,3,4 |
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BONNET-DECHAUME BLANC
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CEREBRAL AVM MIDBRAIN
IPSILATERAL RETINAL VASCULAR MALFOMATION AVM FACIAL SKIN |
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MAFUCCI MALIGNANCIES
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CHONDROSARCOMA
BREAST, OVARIAN, PANCREATIC, PARATHYROID,PITUITARY, |
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BANNAYAN-RILE-FUBALCABA
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AD
MACROCPEAHLY PSUDOPAPILLEDEMA GI POLYPOSIS (HEMANGIOMA) |
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HHT
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AD
MUCOCUTANEOUS AND VISCERAL AVM EPISTAXIS AND MUCOSAL TELANGIECTASIAS MC PRESENTING SX GI AVM |
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HHT TYPE 3
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MADH4 GENE
DOWNSTREAM REGULATOR OF TGF-B ASSOC WITH JUVENILE POLYPOSIS |
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TGF-B STIMULATOR
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VEGF
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MRNA TRANSLATION WHERE
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CYTOPLASM
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DNA MICROARRAYS
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SPECIFIC GENES ON CHIPS AND DAN ALLOWED TO HYBRIDIE
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DRUGS 6 GENE FAMILIES
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1. G PROTEIN COUPLED RECEPTORS
2. PROTEIN KINASES 3. ZINC METALLOPROTEINASES 4. SERINE PROTEASES 5. NUCLEAR HORMONE RECEPTORS 6. PHOSPHODIESTERASES |
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MITF NEVI
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NOT IN NORMAL NEVI
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ACROCHORDONS NECK SIGN OF
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HYPERINSULINEMIA
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TS SPORADIC MUTATIONS
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TSC2 > TSC1
FAMILIAL TSC1 =TCS2 |
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TCS1 OR TCS2 WORSE
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TCS2
INCREASED MR, CORTICAL TUBERS, RETINAL HMARTOMAS, FACIAL ANGIOFIBROMAS |
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TS MAJOR
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1. FACIAL ANGIOFIBROMAS
2. PERIUNGUAL FIBROMA 3. HYPOMELANOTIC MACULES 4. SHAGREEN PATCH 5. RETINAL NODULAR HAMARTOMAS 6. CORICAL TUBER 7. SUBEPENDYMAL NODULE 8. SUBEPENDYMAL GIANT CELL ASTROCYTOMA 9. CARDIAC RHABDOMYOMA 10. LYMPHANGIOMYOMATOSIS 11. RENAL ANGIOMYOLIPOMA |
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TS MINOR
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DENTAL ENAMEL PITS
RECTAL HAMARTOMATOUS POLYPS BONE CYSTS WHITE MATTER READIAL MIGRATION LINES GINGIVAL FIBROMAS NONRENAL HAMARTOMAS RETINAL ACHROMIC PATCH CONFETTI SKIN MULTIPLE RENAL CYSTS |
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TS EARLIES SIGN
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HYPOMELANOTIC MACULES
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HYPOMELANOTIC LESIONS TS MELANOCYTES
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NORMAL MELANOTYCTES
DECREASE DOPA REACTION |
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MC TUMOR IN INFATNS AND CHILDREN TS
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RHABDOMYOMA
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HSV-1 OR CONDYLOMA CUMINATUM > 3-5 YO
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POSSIBLE ABUSE
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HPV < 3 YO
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NON SEXUAL TRANSMISSION MC CAUSE
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HSV DX OF CHOICE FOR ENCHEPHALITIS
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PCR OF INFECTED FLUID
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HSV PRENATAL GREATEST RISK TRIMESTER
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3RD TRIMESTER
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HSV GOLD STANDARD DX
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CULTURE
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FAMCICLOVIR MOA
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INHIBITS DNA POLYMERASE S2 ACYCLOVIR BUT CAUSES DNA CHAIN TERMINATION
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WOMEN MELANOMA BETTER PROGNOSIS WITH PREGNANCIES
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WOMEN WITH 5+ PREGNANCIES HAVE BETTER MELANOMA SURVIVAL RATES
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LYMPHANGIOMA CIRCUMSCRIPTUM EXPRESS
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LYVE-1, VEGFR-2, PROX1 = LYMPHATIC
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PROX1
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HOMEOBOX GENE
LYMPHATIC |
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MC TOPICAL ANTIBACTERIAL AGENT CONTACT DERMATITIS
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NEOMYCIN
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PYODERMA GANGRENOSUM MC LOCATION
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PRETIBIAL
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ZOSTER VACCINE
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60+ YRS
SC INJECTION CONTRAINDICATIONS ANAPLYLATCI REEACTION TO GELATIN, NEOMYCIN, PRIMARY OR ACQUIRED IMMUNODEFICIENCY, IMMUNOSUPPRESSIVE THERAPY, ACTIVE UNTREATED TB, PREGNATN |
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EGFR INHIBITORS ACNEIFORM REACTION ONSET
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7-10 DAYS
WORSE 2ND WEEK SEB DERM AREAS FOLLICULAR PAPULES AND PUSTULES |
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OTHER SIDE EFFECTS OF EGFR RECEPTORS
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PATCHY ALOPECIA
TRICHOMEGALY |
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ACRAL ERYTHEMA
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SORAFENIB, SUNITINIB
DOCETAXEL |
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BORTEZOMIB
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PROTEASOME INHIBITOR
VASCULITIS |
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CAPECTIABINE
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ANITMETABOLITE
INFLAMMATION AKS |
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TEGAFUR
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ANTIMETABOLITE
PPK |
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POST INFLAMMATORY HYPERPIGMENTATION AFTER CO2 LASER DEPENDENT ON
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DEPTH OF LASER
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MYIASIS EGG INFESTED CLOTHING
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CORDYLOBIA ANTHROPOPHAGA
FURUNCULAR MYIASISMIR-2 |
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PSORIATIC SKIN INCREASE LEVELS OF WHICH SMALL RNAS?
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MIR-203 IN KO POSRIATIC SKIN
MIR146a IN LEUKOCYTES AND IN T CELLS, DENDRITIC CELLS, MAST CELLS IN PSORIATIC PATIENTS INHIBITORY EFFECTON TNF-ALPHA PATHWAY |
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MIR203
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MINI RNA PSORIATIC SKIN KO
FORMATION OF PLAQUES |
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SOLAR URTICARIA TYPES`
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1: ABNL CHROMOPHORE
2: IGE ANTIBODIES AGAINST NORMAL CHORMOPHORE |
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PR drug
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Barbiturates
Bismuth Captopril Metronidazole Isotretinoin Penicillamine Levamisole Aspirin Omeprazole Gold Clonidine Imatinib (Gleevec) Terbinafine Hydroxychloroquine |
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