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17 Cards in this Set
- Front
- Back
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Candida
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oval budding yeasts
hyphae and pseudohyphae may be present |
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Cryptococcus neoformans
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spherical budding yeast of variable size
capsule may be present no hyphae or pseudophyphae |
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Aspergillus
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septate, dichotomously branced hyphae
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Zygomycetes
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broad, thin-walled pauciseptate hyphae with nonparallel sides and random branches
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Coccidioides immitis
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spherical, thick-walled spherules (when matured may have endospores)
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Sporothrix schenckii
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yeast-like cells, varying sizes
"cigar shaped" |
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Penicillium marneffi
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oval intracellular yeast cells with septum
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Pneumocystis jiroveci
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cysts are round, collapsed, or crescent shaped
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Dematiaceous moulds
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pigmented hyphae (brown, tan, black)
branched or unbranched |
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Histoplasma capsulatum
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small bidding yeasts within macrophages
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Blastomyces dermatitidis
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large, thicked-walled, broad-based budding yeast
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Polyenes
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(Amphotericin B)
CELL MEMBRANE DAMAGE bind to ergosterol and forms pores and causes oxidative damage |
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Azole Derivatives
Imidazole (ketoconazole) Triazole (fluconazole, itraconazole, voriconazole) broad spectrum |
CELL MEMBRANE SYNTHESIS
inhibit synthesis of ergosterol |
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Echinodandins
caspofungin, micafungin, anidulafungin |
CELL WALL SYNTHESIS
inhibitors of glucan synthesis |
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Antimetabolites
Flucytosine becomes FU in cytoplasm and then FUA which competes for Uracil for RNA synthesis (and possibly DNA synthesis) |
RNA SYNTHESIS
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Allylamines
Terbinafine (systemic) and Naftifine (topically) |
ERGOSTEROL SYNTHESIS
One works systemically and one works topically. |
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Griseovulvin
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MT and INHIBITION OF MEIOSIS
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