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21 Cards in this Set
- Front
- Back
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Amphoteracin B: mode of action
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binds ergosterols (polyene antifungal)
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Amphoteracin B: cidal or static
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fungicidal
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Amphoteracin B: targets
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All systemic fungi (plus penicillium and fusarium?)
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Nystatin: mode of action
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another binds sterols (polyene antifungal)
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Itraconazloe: mode of action
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inhibits ergosterol synthesis at lanosterol C14 a-demethylase (cytochrome P-450-dependent)
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Itaconazole: cidal or static
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fungistatic
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Itaconazole: targets
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yeasts and molds- dermatophytes, dematiaceous moulds, systemic mycoses
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voriconazole: mode of action
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also inhibits ergosterol synthesis at lanosterol C14 a-demethylase (cytochrome P-450-dependent)
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Imidazole: mode of action
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also inhibits ergosterol synthesis at lanosterol C14 a-demethylase (cytochrome P-450-dependent) - toxic problems
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Echinocandins: mode of action
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Inhibits synthesis of B-(1,3)-glucans (cell wall)
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Echinocandins: cidal or static
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fungicidacl (Candida) & fungistatic (Aspergillus)
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Echinocandins: targets
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Candida, Aspergillus
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Flucystosine: mode of action
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Fluorinated pyrimidine analogue (DNA/RNA synthesis)
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Flucosytosine: cidal or static
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Fungistatic (must be used with other therapy)
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Flucosytosine: target
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Candida, Crytococcus
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Terbinafine: mode of action
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An allylamine - inhibits squalene epoxidase, blocks ergosterol synthesis at the squalene
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Terbinafine: target
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dermatomycoses (including onychomycosis) & sporotrichosis, aperfillosis, chromoblastomycosis
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Terbinafine: cidal or static
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fungistatic
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Naftifine: mode of action
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Another allylamine - inhibits squalene epoxidase, blocks ergosterol synthesis at the squalene (topical only)
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Griseofulvin: mode of action
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Disrupts microtubules (with side effects)
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Griseofulvin: tragets
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Dermatophytes (oral aplication)
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