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15 Cards in this Set
- Front
- Back
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________drugs can slow the progression of MS, decrease the frequency and intensity of relapses, and delay permanent neurologic loss
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Disease-modifying
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_______ _______ is a chronic, inflammatory, autoimmune disorder that damages the myelin sheath of neurons in the central nervous system (CNS)
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Multiple sclerosis (MS)
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T of F: MS damages the dendrite, cell body, and nucleus of the cell
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False: MS damages the myelin sheath surrounding the axon
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What are the 4 subtypes of MS?
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1. relapsing-remitting, 2. secondary progressive, 3. primary progressive, 4. progressive relapsing
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Which subtype of MS is most common?
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relapsing-remitting
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The two main types of drugs used to manage MS are
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Immunosuppressants and Immunomodulators
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Interferon beta, glatiramer acetate, and natalizumab are examples of ______
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Immunomodulators
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Immunomodulators are used to treat patients with which subtype of MS?
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Relapsing-remitting
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Name the one immunosuppressant approved by the FDA to treat MS
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Mitoxatrone
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T or F: Mitoxatrone produces greater immunosuppression than the immunomodulator drugs
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True: however, Mitoxatrone therefore has a significantly higher risk of toxicity
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Mitoxatrone can be used to treat all subtypes of MS except:
a. relapsing-remitting b. secondary progressive c. primary progressive d. progressive-relapsing |
C. primary progressive
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Which two MS drugs can cause myelosupression?
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Interferon beta, and Mitoxatrone
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Injection site reactions such as severe chest pain is commonly associated with which Immunomodulator?
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Glatiramer
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Progressive multifocal leukoencephalopathy (PML), a severe CNS infection caused by reactivation of the JC virus can be caused by which Immunomodulator?
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Natalizumab
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T or F: Mitoxatrone would likely be used to treat MS before trying an immunomodulator
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False: Mitoxatrone is an immunosuppressant with a significantly high risk of toxicity. It is reserved for patients who cannot be treated with safer agents.
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