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17 Cards in this Set

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Pathologic Condition: Cardiovascular Disorders
Pharmacokinetic Consequences?
Absorption, distribution,metabolism, and excretion are impaired because of decreased bloodflow to sites of drug administration, drug action, liver and kidneys
Pathologic Condition:
CNS Disorders
Pharmacokinetic Consequences?
may cause hypo or hyper ventilation & acid/base imbalances. Increased blood flow may accelerate all pharmacokeinetic processes.
Pathologic Condition:
GI Disorders
Pharmacokinetic Consequences?
Absorption is impaired w/ oral meds; crushing meds & feeding through Gi tube accerlates absorption
Pathologic Condition:
Inflammatory Bowel Disorders (Crohn's & ulcerative colitis)
Pharmacokinetic Consequences?
Absorption is variable (drugs tend to be absorped more quickly by inflammed tisue) It may be decreased because of hypermotility and diarrhea
Pathologic Condition:
Diabetes-induced cardio disorders
Pharmacokinetic Consequences?
Impaired circulation may decrease all pharmacokinetic processes
Pathologic Condition:
Thyroid disorders
Pharmacokinetic Consequences?
Main effect is on metabolism. Hyperthyroidism slows metabolism amd elimination.
Pathologic Condition:
Adrenal Disorders
Pharmacokinetic Consequences?
decrased adrenal function caused hypotension and shock which impairs all processes
Pathologic Condition:
Hepatic Disorders(hepatitis, cirrhosis)
Pharmacokinetic Consequences?
Increased blood flow increases metabolism and vice versa. Absorption of oral drugs may be decreased in clients w/ cirrhosis due to edema in the GI tract. Distribution may be impaired if the liver is unable to synthesize adequate amounts of plasma proteins, especially albumin. Meatabolism may be impaired by disorders that decrease blood flow. Excretion may bee increased when protein binding is impaired. Excretion os decreased when the liver is inable to metabloize lipid-soluble drugs into water-soluble metabolites that can be excreted by the kidneys.
Pathologic Condition:
Renal Impairments
Pharmacokinetic Consequences?
Absorption of oral drugs may be decreased. Distribution is decreased. Metabolism can be incrased, decreased or unaffected. Excretion is reduced
Pathologic Condition:
Respiratory impairment
Pharmacokinetic Consequences?
Hypoxemia leads to decrased metabolism
Pathologic Condition:
Sepsis-induced alterations
Pharmacokinetic Consequences?
all processes are accelerated
Pathologic Condition:
Shock-induced alterations
Pharmacokinetic Consequences?
impairs all processes
Drugs that are hepatoxic?
acetaminophen(Tylenol), isoniazid(INH), methotreexate (Trexall), Phenytoin (Dilantin) and aspirin and other salicylates
Antimicrobial agents that cause nephrotoxicity?
gentamicin and other aminglycosides, nonsteriodal anti-inflammatory agents (ibuprofin)
Unconsciousness is a majior toxic effect of what commonly injested substances?
benzodiazepine antianxiety and sedative agents, tricyclic antidepressants, ethanol, and opiates
Treatment of choice in severe lithium and aspirin (salicylate) poisoning?
Hemodialysis
What is the trtment for removing toxic ingestions of long-acting , suatained release drugs like beta-blockers and Ca channel blockers?
WBI (Whole bowel irrigation)