Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
24 Cards in this Set
- Front
- Back
|
Certain safety factor
|
CSF = TD1 / ED99
= toxic dose for 1% of test animals / effective dose for 99% of test animals |
|
|
Therapeutic Index
|
TD50 / ED50
toxic dose for 50% of people / effective dose for 50% of people |
|
|
Partition coefficient
|
Poil/water = Pm/b = Cmembrance/Cbuffer
|
|
|
Volume of distribution
|
Vd = Mass of drug injected/concentration of drug in blood. Also measured using Alcohol.
|
|
|
k
|
0.693/half life
|
|
|
Half life
|
t1/2 = 0.693/k
|
|
|
Attained fraction at steady state
|
f = 1 - e^-kt
f = 1 - e^-.693t/half life |
|
|
Drug concentration at certain time
|
Ct = Co * e ^ -kt
|
|
|
Rate of drug input at a steady state/desired rate of drug admin
|
Q = k * Vd * Css
Q = Cl * Css Q = Dm / Tm |
|
|
Loading dose
|
L = Vd * Ctox
|
|
|
Maintenance dose
|
Dm = (Ctox - Cther) * Vd
Dm = Cl * Tm * Css |
|
|
Maintenance interval
|
Dm/Tm = Q = K * V * Css
|
|
|
Total body clearance
|
Cl = k * Vd
Cl = iv dose/AUC Cl= F * dose / AUC (when only a fraction of dose is absorbed) units: ml/min |
|
|
Liver extraction ratio )amount of drug removed by liver)
|
E = (concentration of blood entering liver - concentration of blood leaving liver) / Concentration of blood entering liver
E = (Ca-Cv) ÷ Ca |
|
|
Amount of drug metabolized per minutes in liver
|
= amt of blood flowing through liver * (concentration of blood entering liver - concentration of blood leaving liver)
|
|
|
Rate of hepatic clearance
|
Clh = rate of blood flow through liver * E
|
|
|
Rate of liver (renal) clearance
|
(rate of glomerular filtration + rate of tubular secretion) - rate of tubular reabsorption
|
|
|
Liver & kidney clearance
|
Cl = Clh + Clr
k = kh + kr |
|
|
Efficacy
|
E = beta/alpha
E = transition rate to active state/transition rate form active state |
|
|
Binding affinity Kd
|
Kd = offset rate of binding/onset rate of binding
|
|
|
Potency (Ec50)
|
EC50 = Kd / (1 + E)
|
|
|
Maximum fraction of receptors found in active site in presence of max effective concentration of ligand
|
p = E / (1 + E)
|
|
|
BIoavailability
|
AUC (oral) / AUC (iv)
|
|
|
Bioavailability after passage through liver
|
Fh = 1 - E
|
