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38 Cards in this Set

  • Front
  • Back
what bacteria infect the stomach
H. hylori
what bacteria infect the small intestine
vibrio cholerae
e. coli ETEC
slamonella enteritidis
salmonella typhi
campylobacter
what bacteria infect the larg eintestines
shigella dysenteriae
e. coli. EHEC
vibrio parhaemolyticus
c. diff
what is the class of helicobacter
gram neg, spiral rod
what does helicobacter cause
gastritis
what is the virulence factor of H pylori
flagella allows penetration through gastric mucus
adhesisn mediate binding to host cells
cagA protein -surface pilus needle like injects CagA protein into host cells which is lethal associated only with more virulent strains stimulates inflamation

Urease-nuutralizes gastic acid
Acid inhibitory protein
Mucinase -degrades gastric mucus
Vacuolating cytotoxin-induces vacuolation and cell death in epithelial cells stims neutrophil migration and inflamation
what is the transmision of H pylori
human human fecal oral
how is h pylori diagnosed
biopsy
ureas breath and blood test
what is the treatment of h pylori
proton pump inhibitor for symptoms

sequential therapy
step 1 rabeprazole +amoxicillin 5 days
step 2 rabeprazole + clarithromycin+ tinidaxole 5 days
what class is listeria
gram pos rods or coccbacilli
how is listeria transmitted?
food borne
what are the distinctive factors of listeria
tumbling motitliy
facultative anaerobe
likes cold temps can grow in refig
what are the virulence factors
listeriolysin
-hemolytic toxin-beta hemolysis
ActA -polymerizes actin that push it into another cell
what is a unique transmission mode of listeria
transplacental
what is the usual symptoms of listeria
healthy adult-asymptomatic-mild flu
immunocompromised/elderly- severe invasive disease with meningitis, encephalitis, septicemia
pregnant woomen-flu like illness can lead to septic abortion, premature delivery, stillbirths
neonates- early onset tsepticemia and pneumonia
what is the pathogenesis of listeria
ingestion invasion in epithelia, replication in macrophages like salmonella.
can get into the bloodstream and spread to meninges or across the placenta
how is listeria diagnosed
monocytosis in the peripheral blood and CSF
gram stain of CSF
culture of CSF or blood
how is listeria treated
ampicillin/penicillin
TMP-SMX, erythromycin
resistant to cephalosporins
what are the animal to human food borne diseases
campylobacter
e.coli
salmonella
what are the seafood derived food borne diseases
cholerae
what are the human to human transmission food bourne disease
staph aureus
e. coli
salmonella
shigella
listeria
what disease are caused by ingestion of preformed toxins
clostridium perfringens
staph aureus
bacillus cereus
what class are the clostridiums
large gram pos rods
spore forming(heat resistant)
anaerobe
what is the disease caused b clostridiums
enterotoxins
what is produced by clostridium perfiringens
CO2 and H2 gas
very smelly
what does c. perfringens cause
gas gangrene(alpha toxin creates invasion)
anaerobic celluitis(localized)

can cause enteritis if u get the type that has enterotoxins not as serious or as common
what type of toxin is produced in most human strains of C. perfringens
alpha toxin
kappa toxin
theta toxin
enterotoxins
what is alpha toxin
phospholipase C-breaks down membranes
dermonenecrotic
hemolytic-beta hemolyisis
how is C. perfringens transmitted
exogenous(soil in wound)
endogenous(escape from normal flora in the intestine can be traumatic like surgury or nontraumatic-tumors)
how is c. perfringens diagnosised
gram stain of tissue
shows gram pos rods
what is the treatment of c. perfringens
debridment of necrotic tissue
aggresive treatment with penicillins
hyperbaric oxygen
what are the virulence factors for c diff
Toxin A and toxin B
how does toxin A and B work in c diff
covalen glucosylatino of cellular Rho GTPase interfering with intracellular signaling triggers fluid secretion and cell death and inflammation

toxin be is 100x more cytotoxic than toxin A
what is the NAP1 strain of c. diff
20x more toxins produced
how is c. diff transmitted
overgrowth of normal flora due to antibiotic use

can be acquired via fecal oral route
nosocomial
how is C. diff treated
c. diff is sensitive to vancomycin, metronidazole, fidazomicin

probiotics or fecal transplant to restore normal flora
treatment with flouroquinolins can cause c. diff by killing of normal flora
what is yellow pseuodomenbrane indiciative of.
c. dificile inflamation
how is c. diff diagnosed
yellow pseudomembran
3 unformed stolls per 24 hour day
culture
antigen detection stool kit for toxin A and B and GDH
PCR if unsure