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8 Cards in this Set
- Front
- Back
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What are the 3 laboratory findings in primary folate deficiency?
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1)Increased homocysteine
2)Increased volume in RBC's 3)Decreased RBC folate content |
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What is the treatment for primary folate deficiency?
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Folic acid or Leucovorin (N5-formyl-THF)
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What are the physical findings of someone with cobalamin deficiency?
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Decreased peripheral sensation
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What are the 5 laboratory findings of someone with cobalamin deficiency?
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1) Increased Homocysteine
2) Increased methylmalonic acid and propionic acid in the blood 3) Increased volume of RBC's 4) Decreased concentration of cobalamin in the blood 5) Anemia |
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What is the Folate Trap Hypothesis?
What are the two components? |
Insufficient cobalamin leads to decreased THF and increased N5-methyl-THF.
1) Decreased N5-methyl-THF + Homocysteine --> THF 2) Decreased SAM leads to decreased feedback inhibition of N5/N10-methylene-THF |
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What is the treatment of cobalamin deficiency?
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IM injection of Vitamin B12 every 1-2 months or oral Vitamin B12.
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Why is it important to test for cobalamin deficiency when a folate deficiency is found.
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Cobalamin deficiency and folate deficiency both lead to megaloblastic anemia. Cobalamin deficiency can lead to irreversible brain damage.
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What foods provide folate?
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Grains, fruits, legumes, green leafy vegetables.
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