• Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/27

Click to flip

27 Cards in this Set

  • Front
  • Back
What are common receptors for pneumonia attachment?
1. fibronectin
2. sialic acid
3. IgA
What is fibronectin?
Glycoprotein slime -
- coats epithelial, macrophage and fibroblast cells
What is the point of fibronectin?
- welcoming receptor for endogenous oral flora - Staph and Strep - that when they migrate down to respiratory tract, will be prevented through attachment
What happens to fibronectin production with illness?
Lessens - therefore, become more prone to infections which would be prevented via fibronectin
What is sialic acid?
- N acetyl neuraminic acid
Where is sialic acid found?
- respiratory
- neural
- erythrocytes and lymphocytes
What does IgA do?
prevents binding of bacteria
What do bacteria do to overcome IgA?
have IgA protease
What is the most important virulence factor of bacteria?
Capsule
How does a capsule assist in pathogenesis?
1. antiopsonic - resists IgG binding
2. antiphagocytic - resists vascuolization
3. host mimicry - hyaluronic acid, sialic acid = reduced immune response
What do respiratory bacterial pathogens have in common?
- commonly component of normal flora
- spread person-person close contact
- primaryly asymptomatic, colonizers
- respiratory tropism
- resist neutrophil phagocytosis
- survive poorly out of host
What 7 bacterial pathogens do you need to know?
1. S. pneumoniae
2. H. influenzae
3. Moraxella catarrhalis
4. Klebsiella pneumoniae
5. Chlamydia pneumoniae
6. Mycoplasma pneumoniae
7. Legionella pneumophila
Which pneumonial bacteria are gram positive?
S. pneumoniae
Which pneumonial bacteria are gram negative?
H. influenza
M. catarrhalis
K. pneumoniae
L pneumophila
Which pneumonial bacteria are gram neutral?
M. pneumoniae
C. pneumoniae
Which pneumonial bacteria are have a capsule?
S.pneumoniae
H. influenza
M.catarrhalis
K.pneumoniae
What is serum resistance and which bacterial (pneumonia causing) are serum resistant?
Bacteria not killed in 10% solution of serum
Moraxella and Klebseilla
Which pneumonia causing bacteria have IgA protease?
S.pneumoniae
H.influenza
M.pneumoniae
What produces atypical pneumonia?
M.pneumonia
Describe M.pneumoniae
small bacteria
no cell wall (aka penicillin resistant!)
attaches to sialic acid
What infections does K.pneumoniae cause?
pneumonia
UTI
line related sepsis
Where is Klebsiella found?
water, environment and enteric bacteria
Describe Klebsiella
encapsulated
endotoxin
serum resistant
Enterobacteriaceae
Describe Chlamydia pneumoniae
obligate intracellular parasite
cell wall
strong association with atherosclerotic plaque
Resistant to b lactams - requires macrolides, tetracyclines, fluoroquinolones
Describe Legionella
faintly gram negative rods
blocks phagolysosomal fusion
What are two presentations of Legionella pneumophila?
1. pontiac fever - HCP, fever, cough, fatigue, arthralgia, myalgia, diarrhea
2. Atypical pneumonia - compromised host, resistant to b lactams
What are three virulence characteristics of respiratory bacteria?
1. respiratory tropism - sialic acid residues primarily
2. antiphagocytic capsule or enhanced intraphagocytic survival
3. part of normal flora