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10 Cards in this Set
- Front
- Back
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What mechanism do fluoroquinolones use?
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bactericidal
inhibit DNA synthesis by inhibiting DNA gyrase & topo IV |
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what suffix do the fluoroquinolones use?
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-floxacin
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What is the coverage of the fluoroquinolones?
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mainly aerobic gram - rods
good gram+ coverage including MRSA and PRSP not effective against anaerobes |
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What are the fluorquinolones used as prophylactically?
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anthrax
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What is quinolone DOC for?
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enterobacter, citrobacter, serratia, shigella, salmonella
legionella (with azithro & rifampin) |
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How are fluoroquinolones adminstered? and excreted?
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orally
kidney (so they can be blocked by prorbenicid) |
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What side effects are associated with fluorquinolones?
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GI, visual, seizures, tendonitis, tendon rupture
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What tissues do fluoroquinolones penetrate?
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good tissue
poor CNS |
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Which fluoroquinolone has serious hepatotoxicity?
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trovafloxin
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What are the contraindication of fluoroquinolones?
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pregnant women
children <18 (can cause cartilage damage) |
