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30 Cards in this Set
- Front
- Back
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100. Antidepressants used for OCD?
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a. SSRIs (in high doses)
b. TCAs (clomipramine) |
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101. Antidepressants used for Panic Disorder?
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a. SSRIs
b. TCAs (Imipramine) c. MAOIs |
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102. Antidepressants used for dysthymia?
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a. SSRIs
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103. Antidepressants used for Social phobia?
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a. SSRIs
b. TCAs c. MAOIs |
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104. Antidepressants used for GAD?
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a. SSRI
b. SNRIs (Venlafaxine) c. TCAs |
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105. Antidepressants used for PTSD?
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a. SSRIs
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106. Antidepressants used for IBS?
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a. SSRI
b. TCA |
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108. Antidepressants used for Neuropathic pain?
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a. Amitriptyline and nortriptyline (TCAs)
b. Duloxetine (Cymbalta) (SNRI) |
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109. Antidepressants used for Chronic pain?
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a. SSRIs
b. TCAs |
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110. Antidepressants used for Fibromyalgia?
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a. SSRIs and cymbalta (duloxetine)
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111. Antidepressants used for Migraine HA?
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a. Amitriptyline (TCA)
b. SSRIs |
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115. Antidepressants used for Insomnia?
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a. Mirtazapine (Remeron)
b. Amitriptyline (TCA). |
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118. Warning about atypical antipsychotics?
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a. Although they are used to tx sx of dementia and delirium, studies who an ↑ risk of all-cause mortality and stroke when using these agents in the elderly.
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119. Typical or first-gen antipsychotics, sometimes referred to as neuroleptics, are classified according to potency and treat psychosis by?
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a. Blocking Dopamine D2 receptors.
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120. What do atypical or second-generation antipsychotics (newer) block?
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a. Both D2 and serotonin 2A receptors.
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121. note: Most antipsychotics have a number of actions and receptor interactions in the brain that contribute to their varied efficacy and SE profile.
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121. note: Most antipsychotics have a number of actions and receptor interactions in the brain that contribute to their varied efficacy and SE profile.
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122. What do both the typicals and atypicals have similar efficacies in treating?
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a. Positive psychotic sx, such as hallucinations and delusions.
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123. What are atypical antipsychotics more effective in treating?
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a. Negative sx, such as flattened affect and social withdrawal.
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124. Note: atypical antipsychotics had largely replaced typical antipsychotics in use due to their favourable side effect profile.
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a. However, evidence for metabolic syndrome, wt. gain, and other previously underappreciated side effects, as well as the significant cost, means that currently both classes are first line.
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125. 2 Low potency typical antipsychotics?
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1. Chlorpromazine (Thorazine)
2. Thioridazine (Mellaril) |
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126. MOA of low potency typical antipsychotics (Chlorpromazine and Thioridazine)?
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a. Have a lower affinity for dopamine receptors and therefore a higher dose is required.
b. Remember, potency refers to the actino on dopamine receptors, not the level of efficacy!. |
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127. What do the low potency antipsychotics have a higher incidence of than high-potency?
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a. Anticholinergic and antihistaminic effects.
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128. What do the low potency antipsychotics have a lower incidence of than high-potency?
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a. EPS and neuroleptic malignant syndrome.
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129. Heart risk of low potency antipsychotics?
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a. As a group, they have more lethality in overdose due to QTc prolongation and the potential for heart block and ventricular tachycardia.
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130. Is there a blood risk w/ low potency antipsychotics?
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a. There is a rare risk for agranulocytosis, and they have a slightly higher seizure risk than higher-potency meds.
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131. 3 side effects of Chlorpromazine (Thorazine) (low potency)?
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a. Common: Orthostatic hypotension
b. Can cause bluish skin discolouration c. Photosensitivity |
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132. 2 Non-psychotic uses of chlorpromazine (Thorazine)?
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a. Can treat N/V as well as intractable hiccups.
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133. Unique SE of Thioridazine (Mellaril)?
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a. Associated w/retinitis pigmentosa.
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134. 4 Mid-potency, typical antipsychotics?
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a. Have Midrange properties.
1. Loxapine (Loxitane) 2. Thiothixene (Navane) 3. Trifluoperazine (Stelazine) 4. Perphenazine (Trilafon) |
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135. What is the risk w/Loxapine (Loxitane) and what is the effect of its metabolite?
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a. Higher risk of seizure
b. Metabolite is an antidepressant. c. Loxapine is a mid-potency antipsychotic. |
