First Aid - Pharmacology - Cholinomimetics

Front 1

what inhibits the release of acetylcholine at the nerve termina?

Back 1

botulinum

Front 2

what inhibits the reuptake of choline into the nerve terminal?

Back 2

hemicholinium

Front 3

what inhibits ACh from being packaged into vesicles by ChAT?

Back 3

vesamicol

Front 4

what inhibits the conversion of tyrosine to DOPA?

Back 4

metyrosine

Front 5

what inhibits the packaging of dopamine & NE into vesicles?

Back 5

reserpine

Front 6

what inhibits the reuptake of NE at the nerve terminal?

Back 6

cocain
TCA
amphetamine

Front 7

what prevents release of NE filled vesicles at the nerve terminal?

Back 7

Guanethidine

Front 8

what increases release of NE by nerve?

Back 8

amphetamine

Front 9

on the cardiac NE nerve terminal what is the effect of
alpha2 receptor?
AII receptor?
M2 receptor?

Back 9

alpha2 - inhibits NE release (negative feedback)
AII - promotes NE release (angiotensin II)
M2 - inhibits NE release

Front 10

bethanechold?

Back 10

direct cholinomimetic

-activates bowel & bladder smooth mm
-resistant to AChE

Front 11

what direct cholinomimetic is resistant to AChE?

Back 11

bethanecol (activates bowel & bladder)
pilocarpine (used for emergency glaucoma)

Front 12

carbachol?

Back 12

direct cholinomimetic agonist
(CARBon copy of AcetylCHOLine)
-used for eyes

Front 13

used for postoperative & neurogenic ileus & urinary retention?

Back 13

bethanechol
direct cholinomimetic agonist

Front 14

used for glaucoma, pupillary contraction, & relief of intraocular pressure?

Back 14

Carbachol

Front 15

Pilocarpine?

Back 15

direct cholinomimetic
-contracts mm of eye (open angle)
-contract pupillary sphincter (narrow angle)
-resistant to AChE

Front 16

use for emergency glaucoma?

Back 16

Pilocarpine
direct agonist cholinomimetic
"cry, drool, sweat on PILOw"

potent stim: sweat, tears, saliva

Front 17

challenge test for diagnosis of asthma?

Back 17

Methacholine
direct agonist cholinomimetic
-stimulate muscarinic receptors in airway when inhaled

Front 18

Neostigmine?

Back 18

anticholinesterase (indirect agonist)
NeO = no CNS penetration

used for postop neurogen ilues & urinary retention; myasthenia gravis, reversal of NMJ

Front 19

Pyridostigmine?

Back 19

anticholinesterase
used for myasthenia gravis (long acting)
does NOT penetrate CNS

pyRIDostigmine gets RID of myasthenia gravis

Front 20

use for dx of myasthenia gravis?

Back 20

Edrophonium
(anticholinesterase)
extremely short acting

Front 21

Edrophonium?

Back 21

anticholinesterase; extremely short acting
use for dx myasthenia gravis

Front 22

Physostigmine?

Back 22

anticholinesterase
use for glaucoma (crosses BBB)
use for atropine overdose

Front 23

tx for atropine OD?

Back 23

physostigmine

Front 24

anticholinesterase useful in glauchoma?

Back 24

Physostigmine (crosses BBB)
Echothiophate

Front 25

echothiophate?

Back 25

anticholinesterase
use for glaucoma

Front 26

anticholinesterase for Alzheimer's?

Back 26

Donepezil

Front 27

Donepizil?

Back 27

anticholinesterase
used for Alzheimer's

Front 28

what are potential complications of cholinomimetic agents?

Back 28

COPD exacerbation
asthma
peptic ulcers

Front 29

cholinesterase inhibitor poisoning? antidote?

Back 29

antidoe - atropine + pralidoxime (regenerates active AChE)

DUMBBELSS
diarrhea
urination
miosis
bronchospasm
bradycardia
Excitation - skeletal mm, CNS
Lacrimation
Sweating
Salivation