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82 Cards in this Set
- Front
- Back
- 3rd side (hint)
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L-dopa/carbidopa
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DA agonist. Carbidopa inhibits peripheral AADC
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Bromocriptine
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DA agonist. PD
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Pramipexole
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DA agonist. PD
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Ropinerole
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DA agonist. PD
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Selegiline
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MAO B inhibitor. PD
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Pargyline
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MAO B inhibitor. old. NOT pergolide
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Pergolide
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DA agonist. PD. old. pergoliDDDDDDe. not pargyline
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Talcapone
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COMT inh. PD
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Entacapone
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COMT inh. PD
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Amantadine
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inhibits influenza virus uncoating. also work in PD (may inc DA release)
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Benztropine
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~atropin. M antagonist. PD for pin rolling, rigidity.
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Sumatriptan
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Seratonin agonist (5HT1d). Vasoconstriction (acute migraine). Tox: coronary vasospams (not for CAD, prinzmetal's angina)
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Carbamazepine
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stabilize Na+ in inactivated state (use dep).
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Phenytoin
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stabilize Na+ in inactivated state (use dep).
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Lamotrigine
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stabilize Na+ in inactivated state (use dep).
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Valproic acid
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stabilize Na+ in inactivated state (use dep). Inhibit T-type Ca2+ channels. Inc [GABA].
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Ethosuximide
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Inhibit T-type Ca2+ channels.
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Topiramate
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Block Na+ channels, inc GABA action.
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Gabapentin
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inc GABA release
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Partial - Simple
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Phenytoin, Carbamazepine, Valproic acid
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Partial - Complex
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Phenytoin, Carbamazepine, Valproic acid
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Tonic - Clonic
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Phenytoin, Carbamazepine, Valproic acid
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Absence
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1) Ethosuximide 2) Valproic acid ONLY
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Status Epilepticus
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Phenytoin (prophylaxis), diazepam/lorazepam (acutel).
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Trigeminal neuralgia
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Carbamazepine
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Seizure in preg or kid
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Phenobarbital
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Myoclonic seizures
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Valproic acid
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Eclampsia
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1) Mg2+ 2) diazepam, lorazepam
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Carbamazepine tox
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Carbombs (diplopia, ataxia, liver tox, teratogenesis), Blood dyscrasias (agranulocytosis, aplastic anemia), induce P450
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Ethosuximide tox
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Hangover (GI, lethargy), Allergy (urticaria, Stevens-Johnson)
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Phenytion tox
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Carbombs (diplopia, ataxia), nystagmus, hirsutism, megaloblastic anemia (B12), teratogenesis, SLE-like (HIPP), induce P450, gingival hyperplasia
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Valproic acid tox
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nerual tube defects (inh folate abs), wt gain, rare/fatal hepatotoxicity
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Lamotrigine tox
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Stevens Johnson
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Gabapentin tox
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ataxia
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Topiramate
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kindey stones (~tophi ~ kidney stones)
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Short acting benzo
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Triazolam, Oxazepam, midazolam. TOM thumb
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Antipsychotics, typica
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d2 antagonist. Use: psychosis, acute mania, Tourette. Tox: 1) EPS/tardive dyskinesia 2) hyperprolactinemia 3) anti H1/M1/a1. 4) Neuroleptic Malignant Syndrome. Names: haloperidol, chlorpromazine, fluphenazine, theoridazine.
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None
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Evolution of EPS w/ atypical antipsychotics
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4hr: acute dyskinesia. 4d: akinesia. 4wk: akanthesia. 4 mo: tardive dyskinesia (~irrev).
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Atypical antipsychotics
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5HT2 antagonists. Use: schizo pos AND neg sx, (Olanzapine: OCD, anxiety, depression, mania, Tourette). Tox: Clozapine-agranulocytosis. Names: it's not ATYPICAL for OLd CLOSets to RISPER. Olanzapine, clozapine, risperidone.
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None
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Lithium tox
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LMNOP. Movement (tremor), Nephrogenic diabetes inspidus, hypOthyroidism, Preg: teratogenicity
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SSRI
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selective seratonin reuptake inhibitors. Use: depression, OCD. Tox: Sexual side effects (anorgasmia; use for premature ejaculation), Seratonin Syndrome w/ MAOi (Rigidity, hyperthermia, cardiovascular collapse). F your PARtner while CITing on a SERTA.
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None
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TCA
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inhibit NE and 5HT reuptake. Depression, OCD (clomipramine), bedwetting (imipramine, stage 4 sleep). S/e: anti H1, M1, alpha1. Tox: Convulsion, Coma, Cardiotoxicity (arrhythmias). Names: _ipramine + _tryptyline. Imiprmaine, Desipramine (least sedating), clomipramine, amitryptiline, nortriptyline, doxepin.
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None
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Buproprion
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Depression, smoking. S/e: stimulant, seizures
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Venlafaxine
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inhibit Ne and 5HT reuptake. S/e: stimulant, constipation
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Duloxetine
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inhibit NE and 5HT reuptake.
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Mirtazapine
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a2 antagonist. S/e: sedation, dry mouth
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Maprotiline
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inhibit NE reuptake. S/e: sedation, hypotension
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Trazodone
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inhibit 5HT reuptake. S/e: sedation, hypotension
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MAOi
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Tranylcypromine, phenelzine. s/e hypertensive crisis (tyramine, mirtazapine), seratonin syndrome (busprion, fluoxetine, paroxetine, citalopram, sertraline, venlafaxine, duloxetine)
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General anesthetics - solubility in blood
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inc solubility in blood = slower induction/recovery
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General anesthetics - lipid solubility
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inc lipid solubility = inc potency = dec MAC
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Halothane
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high lipid and blood solubility. (N2O = opposite) => high potency, slow on/off. Hepatic necrosis.
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Methoxyflurane
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Nephrotoxicity
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Enflurance
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convulsant
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general anesthetics tox
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malignant hyperthermia
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Local anesthetics: fiber order
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small > large (most imp). myelinated > unmeylinated.
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Succinylcholine
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Phase I block: depolarized, no antidote. Phase II block: repolarized but R blocked; rev w/ cholinesterase inh (neostigmine, physostigmine)
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Nondepolarizing muscle relaxants
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Tubocurarine, atracurium, mivacurium, pancuronium, cevuronium, rapacuronium. Rev w/ neostigmine, edrophoium, etc.
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LTB4
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PMN chemotaxis
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LTC4, D4, E4
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bronchoconstriction, vasoconstriction, vaso permeability, smooth m contraction
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prostacycline (PGI2)
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bronchodilation, vasodilation, dec platelet aggregation, uterine relax
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PGE, PGF
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bronchodilation, vasodilation, uterine contraction
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TXA
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bronchoconstriction, vasoconstrction, inc platelet aggregation
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corticosteroids
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inh phospholipase A2. inh COX synthesis, cytokine synthesis, inh NFkB. For asthma: beclomethasone, prednisone
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Zileuton
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inhibit LOX
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NSAIDS
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inhibit COX
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Acetominophen
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inhibit COX
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Coxibs
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inhibit COX
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Zafirlukast
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leukotriene R antagonist
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Montelukast
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leukotriene R antagonist
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Diphenhydramine
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1st gen H1 antagonist. Use: allergy, sleep aid, motion sickness. Tox: anti H1 (sedation), anti M1 (dry eyes/mouth), anti a1 (hypotension)
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Dimenhydrinate
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1st gen H1 antagonist. Use: allergy, sleep aid, motion sickness. Tox: anti H1 (sedation), anti M1 (dry eyes/mouth), anti a1 (hypotension).
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Chlorpheniramine
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1st gen H1 antagonist. Use: allergy, sleep aid, motion sickness. Tox: anti H1 (sedation), anti M1 (dry eyes/mouth), anti a1 (hypotension)
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Loratidine
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2nd gen H1 antagonist. Use: allergy. Tox: less sedating that 1st gen
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Desloratidine
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2nd gen H1 antagonist. Use: allergy. Tox: less sedating that 1st gen
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Fexofenadine
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2nd gen H1 antagonist. Use: allergy. Tox: less sedating that 1st gen
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Isoproterenol
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b1=b2 agonist. bronchodilation. Tox: tachycardia
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Albuterol
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b2 agonist. short acting => acute
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Salmeterol
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b2 agonist. long acting => prophylaxis
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Ipatropium
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M Ach R antagonist. prevent bronchoconstriction
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Theophylline
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inh phosphodiesterase. inc cAMP => bronchodilation
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Cromolyn
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mast cell stabilizer
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