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82 Cards in this Set

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L-dopa/carbidopa
DA agonist. Carbidopa inhibits peripheral AADC
Bromocriptine
DA agonist. PD
Pramipexole
DA agonist. PD
Ropinerole
DA agonist. PD
Selegiline
MAO B inhibitor. PD
Pargyline
MAO B inhibitor. old. NOT pergolide
Pergolide
DA agonist. PD. old. pergoliDDDDDDe. not pargyline
Talcapone
COMT inh. PD
Entacapone
COMT inh. PD
Amantadine
inhibits influenza virus uncoating. also work in PD (may inc DA release)
Benztropine
~atropin. M antagonist. PD for pin rolling, rigidity.
Sumatriptan
Seratonin agonist (5HT1d). Vasoconstriction (acute migraine). Tox: coronary vasospams (not for CAD, prinzmetal's angina)
Carbamazepine
stabilize Na+ in inactivated state (use dep).
Phenytoin
stabilize Na+ in inactivated state (use dep).
Lamotrigine
stabilize Na+ in inactivated state (use dep).
Valproic acid
stabilize Na+ in inactivated state (use dep). Inhibit T-type Ca2+ channels. Inc [GABA].
Ethosuximide
Inhibit T-type Ca2+ channels.
Topiramate
Block Na+ channels, inc GABA action.
Gabapentin
inc GABA release
Partial - Simple
Phenytoin, Carbamazepine, Valproic acid
Partial - Complex
Phenytoin, Carbamazepine, Valproic acid
Tonic - Clonic
Phenytoin, Carbamazepine, Valproic acid
Absence
1) Ethosuximide 2) Valproic acid ONLY
Status Epilepticus
Phenytoin (prophylaxis), diazepam/lorazepam (acutel).
Trigeminal neuralgia
Carbamazepine
Seizure in preg or kid
Phenobarbital
Myoclonic seizures
Valproic acid
Eclampsia
1) Mg2+ 2) diazepam, lorazepam
Carbamazepine tox
Carbombs (diplopia, ataxia, liver tox, teratogenesis), Blood dyscrasias (agranulocytosis, aplastic anemia), induce P450
Ethosuximide tox
Hangover (GI, lethargy), Allergy (urticaria, Stevens-Johnson)
Phenytion tox
Carbombs (diplopia, ataxia), nystagmus, hirsutism, megaloblastic anemia (B12), teratogenesis, SLE-like (HIPP), induce P450, gingival hyperplasia
Valproic acid tox
nerual tube defects (inh folate abs), wt gain, rare/fatal hepatotoxicity
Lamotrigine tox
Stevens Johnson
Gabapentin tox
ataxia
Topiramate
kindey stones (~tophi ~ kidney stones)
Short acting benzo
Triazolam, Oxazepam, midazolam. TOM thumb
Antipsychotics, typica
d2 antagonist. Use: psychosis, acute mania, Tourette. Tox: 1) EPS/tardive dyskinesia 2) hyperprolactinemia 3) anti H1/M1/a1. 4) Neuroleptic Malignant Syndrome. Names: haloperidol, chlorpromazine, fluphenazine, theoridazine.
None
Evolution of EPS w/ atypical antipsychotics
4hr: acute dyskinesia. 4d: akinesia. 4wk: akanthesia. 4 mo: tardive dyskinesia (~irrev).
Atypical antipsychotics
5HT2 antagonists. Use: schizo pos AND neg sx, (Olanzapine: OCD, anxiety, depression, mania, Tourette). Tox: Clozapine-agranulocytosis. Names: it's not ATYPICAL for OLd CLOSets to RISPER. Olanzapine, clozapine, risperidone.
None
Lithium tox
LMNOP. Movement (tremor), Nephrogenic diabetes inspidus, hypOthyroidism, Preg: teratogenicity
SSRI
selective seratonin reuptake inhibitors. Use: depression, OCD. Tox: Sexual side effects (anorgasmia; use for premature ejaculation), Seratonin Syndrome w/ MAOi (Rigidity, hyperthermia, cardiovascular collapse). F your PARtner while CITing on a SERTA.
None
TCA
inhibit NE and 5HT reuptake. Depression, OCD (clomipramine), bedwetting (imipramine, stage 4 sleep). S/e: anti H1, M1, alpha1. Tox: Convulsion, Coma, Cardiotoxicity (arrhythmias). Names: _ipramine + _tryptyline. Imiprmaine, Desipramine (least sedating), clomipramine, amitryptiline, nortriptyline, doxepin.
None
Buproprion
Depression, smoking. S/e: stimulant, seizures
Venlafaxine
inhibit Ne and 5HT reuptake. S/e: stimulant, constipation
Duloxetine
inhibit NE and 5HT reuptake.
Mirtazapine
a2 antagonist. S/e: sedation, dry mouth
Maprotiline
inhibit NE reuptake. S/e: sedation, hypotension
Trazodone
inhibit 5HT reuptake. S/e: sedation, hypotension
MAOi
Tranylcypromine, phenelzine. s/e hypertensive crisis (tyramine, mirtazapine), seratonin syndrome (busprion, fluoxetine, paroxetine, citalopram, sertraline, venlafaxine, duloxetine)
General anesthetics - solubility in blood
inc solubility in blood = slower induction/recovery
General anesthetics - lipid solubility
inc lipid solubility = inc potency = dec MAC
Halothane
high lipid and blood solubility. (N2O = opposite) => high potency, slow on/off. Hepatic necrosis.
Methoxyflurane
Nephrotoxicity
Enflurance
convulsant
general anesthetics tox
malignant hyperthermia
Local anesthetics: fiber order
small > large (most imp). myelinated > unmeylinated.
Succinylcholine
Phase I block: depolarized, no antidote. Phase II block: repolarized but R blocked; rev w/ cholinesterase inh (neostigmine, physostigmine)
Nondepolarizing muscle relaxants
Tubocurarine, atracurium, mivacurium, pancuronium, cevuronium, rapacuronium. Rev w/ neostigmine, edrophoium, etc.
LTB4
PMN chemotaxis
LTC4, D4, E4
bronchoconstriction, vasoconstriction, vaso permeability, smooth m contraction
prostacycline (PGI2)
bronchodilation, vasodilation, dec platelet aggregation, uterine relax
PGE, PGF
bronchodilation, vasodilation, uterine contraction
TXA
bronchoconstriction, vasoconstrction, inc platelet aggregation
corticosteroids
inh phospholipase A2. inh COX synthesis, cytokine synthesis, inh NFkB. For asthma: beclomethasone, prednisone
Zileuton
inhibit LOX
NSAIDS
inhibit COX
Acetominophen
inhibit COX
Coxibs
inhibit COX
Zafirlukast
leukotriene R antagonist
Montelukast
leukotriene R antagonist
Diphenhydramine
1st gen H1 antagonist. Use: allergy, sleep aid, motion sickness. Tox: anti H1 (sedation), anti M1 (dry eyes/mouth), anti a1 (hypotension)
Dimenhydrinate
1st gen H1 antagonist. Use: allergy, sleep aid, motion sickness. Tox: anti H1 (sedation), anti M1 (dry eyes/mouth), anti a1 (hypotension).
Chlorpheniramine
1st gen H1 antagonist. Use: allergy, sleep aid, motion sickness. Tox: anti H1 (sedation), anti M1 (dry eyes/mouth), anti a1 (hypotension)
Loratidine
2nd gen H1 antagonist. Use: allergy. Tox: less sedating that 1st gen
Desloratidine
2nd gen H1 antagonist. Use: allergy. Tox: less sedating that 1st gen
Fexofenadine
2nd gen H1 antagonist. Use: allergy. Tox: less sedating that 1st gen
Isoproterenol
b1=b2 agonist. bronchodilation. Tox: tachycardia
Albuterol
b2 agonist. short acting => acute
Salmeterol
b2 agonist. long acting => prophylaxis
Ipatropium
M Ach R antagonist. prevent bronchoconstriction
Theophylline
inh phosphodiesterase. inc cAMP => bronchodilation
Cromolyn
mast cell stabilizer