Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
55 Cards in this Set
- Front
- Back
- 3rd side (hint)
|
Radiation exposure is associated with what neoplasms?
|
Sarcomas,
papillary thyroid cancer, leukemia |
|
|
|
The oncogene abl is associated with what tumor =
and has what gene product = |
CML,
tyrosine kinase |
|
|
|
The oncogene c-myc is associated with what tumor =
and has what gene product = |
Burkitt's lymphoma
transcription factor |
|
|
|
The oncogene bcl-2 is associated with what tumor =
and has what gene product = |
follicular lymphoma, it is anti-apoptotic
|
|
|
|
The oncogene erb-B2 is associated with what tumor =
and has what gene product? |
breast, ovarian, and gastric carcinomas
and associated with tyrosine kinase |
|
|
|
The oncogene ras is associated with what tumor =
and has what gene product= |
colon carcinoma,
GTPase |
|
|
|
The oncogene L-myc is associated with what neoplasm
and has what gene product? |
lung tumor,
transcription factor |
|
|
|
The oncogene n-myc is associated with what neoplasm =
and has what gene product? |
neuroblastoma,
transcription factor |
|
|
|
The oncogene ret is associated with what neoplasm =
and has what gene product? |
multiple endocrine neoplasia
(MEN) types IIA and IIB, tyrosine kinase |
|
|
|
The oncogene "c-kit" is associated with what neoplasm =
and has what gene product? |
gastrointestinal stromal tumor (GIST)
cytokine receptor |
|
|
|
Li-Fraumeni syndrome is characterized by a mutation in what gene?
|
p53
|
|
|
|
Breast and ovarian cancer is associated with what gene mutation?
Breast cancer alone is associated with what gene mutation? |
breast and ovarian - BRCA1,
breast cancer alone -BRCA2 |
|
|
|
A mutation in p16 is associated with what tumor?
|
melanoma
mutation in = |
p16
|
|
|
A mutation in APC is associated with what tumor?
|
Colorectal cancer
(associated with FAP) = |
mutation in APC
|
|
|
A mutation in WT1 is associated with what tumor?
|
Wilm's tumor
mutation in = |
WT1
|
|
|
A mutation in NF1 is associated with what tumor?
|
Neurofibromatosis Type 1
mutation in = |
NF1
|
|
|
A mutation in DPC is associated with what tumor?
|
pancreatic cancer
A mutation in = |
DPC
|
|
|
A mutation in DCC is associated with what tumor?
|
colon cancer
A mutation in = |
DCC
|
|
|
This is a carcinoembryonic antigen that is very nonspecific but is produced by 70% of colorectal and pancreatic cancers; also produced by gastric, breast, and thyroid medullary carcinomas
|
CEA
= |
70% of colorectal and pancreatic cancers;
also produced by gastric, breast, thyroid medullary carcinomas |
|
|
With hepatocellular carcinomas and nonseminomatous germ cell tumors (such as yolk sac tumors) this tumor marker is increased
|
alpha-fetoprotein
Dz-s = |
hepatocellular carcinomas
and nonseminomatous germ cell tumors (such as yolk sac tumors) |
|
|
Beta-HCG
is increased in what tumors? |
Hydatidiform moles, choriocarcinomas,
gestational trophoblastic tumors what is increased = |
Beta-HCG
|
|
|
CA125 is increased in what types of tumors?
|
ovarian,
malignant epithelial tumors what is increased = |
CA125
|
|
|
S100 is increased in what types of tumors?
|
melanoma, neural tumor, schwannomas
is increased = |
S100
|
|
|
Alkaline phosphatase is increased in what type of tumors?
|
metastases to bone,
obstructive biliary disease, Paget's disease of the bone whatis increased = |
Alkaline phosphatase
|
|
|
Bombesin is a tumor marker for what types of neoplasms?
|
neuroblastoma, lung and gastric cancer
tumor marker is = |
Bombesin
|
|
|
TRAP is a tumor marker for what types of neoplasm?
|
Hairy cell leukemia
tumor marker is = |
TRAP
|
|
|
CA-19-9 is a tumor marker for what type of neoplasm?
|
Pancreatic adenocarcinoma
= |
CA-19-9
|
|
|
Calcitonin is a tumor marker for what type of neoplasm?
|
thyroid medullary carcinoma
tumor marker is = |
Calcitonin
|
|
|
EBV is associated with what cancers?
|
Burkitt's lymphoma,
Hodgkin's lymphoma, nasopharyngeal carcinoma = |
EBV
|
|
|
Cervical carcinoma (16,18) and penile/anal carcinomas are associated with what cancers?
|
HPV
= |
Cervical carcinoma (16,18)
penile/anal carcinomas |
|
|
Kaposi's sarcoma and body cavity fluid B-cell lymphoma is associated with what viral infection?
|
HHV8
= |
Kaposi's sarcoma
body cavity fluid B-cell lymphoma |
|
|
Primary CNS lymphoma is associated with what viral infection?
|
HIV
= |
Primary CNS lymphoma
|
|
|
H.pylori is associated with what cancer?
|
gastric adenocarcinoma and lymphoma
= |
H.pylori
|
|
|
Schistosoma haematobium is associated with what cancer?
|
squamous cell carcinoma of transitional epithelium, e.g. bladder
= |
Schistosoma haematobium
|
|
|
Aflatoxins produced by ____ can lead to _____ carcinoma
|
aspergillus, hepatocellular
= |
Aflatoxins
|
|
|
Vinyl chloride is a carcinogen that can lead to _____
|
angiosarcoma of the liver
= |
Vinyl chloride
|
|
|
CCL4 is a carcinogen and can impact what organ and cause what?
|
liver, centrilobular necrosis, fatty change
= |
CCL4
|
|
|
Nitrosamines (found in smoked foods) can impact what organ and cause what?
|
stomach,
gastric cancer = |
Nitrosamines
|
|
|
Cigarette smoke can impact the
larynx and cause ______, lung and cause _______, kidney and cause ______, bladder and cause _______ |
-squamous cell carcinoma;
-squamous small cell carcinoma; -renal cell carcinoma; transitional cell carcinoma |
|
|
|
Asbestos can impact what organ and cause what?
|
lung, mesothelioma and bronchogenic carcinoma
= |
Asbestos
|
|
|
Arsenic can affect the skin and cause ______, or it can affect the liver and cause ______
|
squamous cell carcinoma, angiosarcoma
= |
Arsenic
liver |
|
|
Naphthalene (aniline dyes) can impact what organ and cause what?
|
bladder, transitional cell carcinoma
= |
Naphthalene (aniline dyes)
|
|
|
Alkylating agents can impact what organ and cause what?
|
blood,
leukemia = |
Alkylating agents
|
|
|
Small cell lung carcinoma can produce ectopic _____ which can lead to Cushings syndrome
|
ACTH
carcinoma can produce ectopic = |
Small cell lung carcinoma
|
|
|
Small cell lung carcinoma and intracranial neoplasms can produce ectopic _____ which can lead to SIADH
|
ADH
= |
Small cell lung carcinoma
intracranial neoplasms |
|
|
Squamous cell lung carcinoma, renal cell carcinoma, and breast carcinoma can produce ____ which can lead to hypercalcemia
|
PTH related peptide
what produces this = |
Squamous cell lung carcinoma,
renal cell carcinoma, breast carcinoma |
|
|
Renal cell carcinoma hemangioblastoma,
hepatocellular carcinoma, pheochromocytoma can produce ____ which can lead to polycythemia |
erythropoietin
|
|
|
|
A thymoma and small cell lung carcinoma can produce effects such as antibodies against presynaptic calcium channels at neuromuscular junction. This can cause _____ syndrome
|
Lambert-Eaton syndrome
= |
A thymoma and small cell lung carcinoma can produce effects such as antibodies against presynaptic calcium channels at neuromuscular junction.
|
|
|
Leukemias and lymphomas can lead to hyperuricemia to excess nucleic acid turnover. This can lead to what effects?
2ct |
gout,
urate nephropathy = |
|
|
|
Psammoma bodies are laminated, concentric, ____ spherules seen in what 4 conditions?
|
they are calcified and seen in
papillary adenocarcinoma of thyroid, serus papaillary cystadnocarcnoma of ovary, meningioma, malignant mesothelioma |
|
|
|
What is the leading cause of cancer death in both men and women?/
|
lung
|
|
|
|
What primary tumors like to metastasize to the brain?
|
lung,
breast, kidney, skin (melanoma) = |
|
|
|
What primary tumors like to metastasize to the liver?
|
colon,
stomach, pancreas = |
|
|
|
What primary tumors like to metastasize to the bone?
|
prostate, breast, lung, thyroid, testes
metastasize to = |
bone
|
|
|
Does lung metastases cause osteolytic or osteoblastic lesions? What about prostate mestastases to bone?
|
lung - lytic; prostate -blastic
|
|
