First Aid Immunology

Front 1

What is the primary lymph node drainage site for the Upper limb/lateral breast?

Back 1

Axillary

Front 2

What is the primary lymph node drainage site for the stomach?

Back 2

Celiac

Front 3

What is the primary lymph node drainage site for the duodenum/jejunum?

Back 3

Superior mesenteric

Front 4

What is the primary lymph node drainage site for the sigmoid colon?

Back 4

Inferior mesenteric

Front 5

What is the primary lymph node drainage site for the Rectum (above pectinate line)

Back 5

Internal iliac

Front 6

What is the primary lymph node drainage site for the rectum (below the pectinate line)

Back 6

Superficial inguinal

Front 7

What is the primary lymph node drainage site for the testes?

Back 7

Superficial and deep plexuses --> para-aortic

Front 8

What is the primary lymph node drainage site for the scrotum?

Back 8

Superficial inguinal

Front 9

What is the primary lymph node drainage site for the thigh?

Back 9

Superficial inguinal

Front 10

What is the primary lymph node drainage site for the lateral side of dorsum foot?

Back 10

Popliteal

Front 11

What type of organisms is an individual with splenic dysfunction susceptible to?

Back 11

Encapsulated bacteria (S SHiN, Salmonella, S. pneumo, H. influenzae, N. Meningitidis)

Front 12

Which MHC is expressed on almost all nucleated cells?

Back 12

MHC I

Front 13

Which MHC is expressed only on APCs?

Back 13

MHC II

Front 14

Which HLA subtype is a/w Hemochromatosis?

Back 14

A3

Front 15

Which HLA subtype is a/w Psoriasis, Akylosing spnondylitis, IBD, and Reiter's?

Back 15

B27

Front 16

Which HLA subtype is a/w Grave's dz?

Back 16

B8

Front 17

Which HLA subtype is a/w MS, hay fever, SLE, Goodpasture's?

Back 17

DR2

Front 18

Which HLA subtype is a/w diabetes type I?

Back 18

DR3

Front 19

Which HLA subtype is a/w RA & type I DM?

Back 19

DR4

Front 20

Which HLA subtype is a/w Pernicious anemia --> B12 def, and Hashimoto's thyroiditis?

Back 20

DR5

Front 21

Which HLA subtype is a/w steroid-responsive nephrotic syndrome?

Back 21

DR7

Front 22

Which cytokines enhance the activity of NK cells?

Back 22

IL-12, IFN-alpha, IFN-beta

Front 23

Which hypersensitivity types are mediated by B cells?

Back 23

I, II and III

Front 24

What is negative selection and in what area of the thymus does it occur?

Back 24

T-cells with high affinity to self antigens undergo apoptosis. Occurs in the medulla

Front 25

What is the function of Th1 cells?

Back 25

Make IL-2 and IFN-gamma --> activate macrophages and cytotoxic T cells

Front 26

Th2 cells bind to what B cell receptor to trigger activation?

Back 26

CD40

Front 27

Which cytokines are secreted by Th2 cells?

Back 27

IL-4, IL-5 and IL-10

Front 28

Which cytokine inhibits Th2 cells?

Back 28

INF-gamma

Front 29

Whch cytokine inhibits Th1 cells?

Back 29

IL-10

Front 30

Which Ig provides infants with passive immunity?

Back 30

IgG

Front 31

Which Ig is found in breast milk?

Back 31

IgA

Front 32

Which Ig fix complement?

Back 32

IgG and IgM

Front 33

What are the structures of C3 convertases and their associated pathways?

Back 33

C4b2a --> Classic

C3bBb --> Alternate

Front 34

Which complement deficiency --> hereditary angioedema?

Back 34

C1 esterase inhibitor deficiency

Front 35

Which complement deficiency --> severe recurrent pyogenic sinus and respiratory tract infections and increased susceptibility to type III hypersensitivity reactions?

Back 35

C3 deficiency

Front 36

Which complement deficiency leads to recurrent Neisseria bacteremia?

Back 36

C5-C8 deficiencies

Front 37

Which drug is contraindicated in C1 esterase deficiency?

Back 37

ACE inhibitor

Front 38

Which complement deficiency leads to complement-mediated lysis of RBCs and paroxysmal nocturnal hemoglobinuria?

Back 38

DAF

Front 39

Which cytokine causes fever and acute inflamation?

Back 39

IL-1

Front 40

Which cytokine, secreted by macrophages and Th cells, is an endogenous pyrogen and stimulates production of acute-phase proteins?

Back 40

IL-6

Front 41

Which cytokine, secreted by macrophages, is the major chemotactic factor for neutrophils?

Back 41

IL-8

Front 42

Which cytokine, secreted by macrophages and B cells, activates NKs and differentiation of T --> Th1?

Back 42

IL-12 (gives the "1, 2 punch")

Front 43

Which cytokine, secreted by macrophages, mediates septic shock, activates endothelium and causes leukocyte recruitment?

Back 43

TNF-alpha

Front 44

Which cytokine, secreted by all T cells, supports growth and differentiation of bone marrow stem cells and functions like GM-CSF?

Back 44

IL-3

Front 45

Which cytokine, secreted by Th1 cells, stimulates the growth of helper and cytotoxic T cells?

Back 45

IL-2

Front 46

Which cytokine, secreted by Th1 cells, suppresses Th2 cells?

Back 46

INF-gamma

Front 47

Which cytokine, secreted by Th2 cells, suppresses Th1 cells?

Back 47

IL-10

Front 48

Which cytokine, secreted by Th2 cells, enhances class switching to IgE and IgG?

Back 48

IL-4

Front 49

Which cytokine, secreted by Th2 cells, promotes differentiation of B cells?

Back 49

IL-5

Front 50

Which cell surface protein binds B7 on APCs?

Back 50

CD28

Front 51

Which cell surface protein is the receptor for EBV?

Back 51

CD21

Front 52

Which cell surface protein is the unique marker for NK cells?

Back 52

CD56

Front 53

What type of vaccine is the MMR?

Back 53

live attenuated

Front 54

Which disorder is a/w the following autoantibody:

ANA?

Back 54

SLE

Front 55

Which disorder is a/w the following autoantibody:

Anti-dsDNA, anti-Smith?

Back 55

SLE

Front 56

Which disorder is a/w the following autoantibody:

Antihistone?

Back 56

Drug-induced lupus

Front 57

Which disorder is a/w the following autoantibody:

Anti-IgG?

Back 57

RA

Front 58

Which disorder is a/w the following autoantibody:

Anticentromere?

Back 58

Scleroderma (CREST)

Front 59

Which disorder is a/w the following autoantibody:

Anti-Scl-70?

Back 59

Scleroderma (diffuse)

Front 60

Which disorder is a/w the following autoantibody:

Antimitochonrial?

Back 60

Primary biliary cirrhosis

Front 61

Which disorder is a/w the following autoantibody:

Anti-desmoglein?

Back 61

Pemphigus vulgaris

Front 62

Which disorder is a/w the following autoantibody:

Anti-Jo-1

Back 62

Polymyositis, dermatomyositis

Front 63

Which disorder is a/w the following autoantibody:

Anti-SS-A (Anti-Ro)?

Back 63

Sjogren's syndrome

Front 64

Which disorder is a/w the following autoantibody:

Anti-smooth-muscle?

Back 64

Autoimmune hepatitis

Front 65

Which disorder is a/w the following autoantibody:

Anti-glutamate decarboxylase?

Back 65

Type 1 DM

Front 66

Which disorder is a/w the following autoantibody:

c-ANCA?

Back 66

Wegener's granulomatosis

Front 67

Which immunodeficiency presents with recurrent bac infections after 6 months?

Back 67

Bruton's agammaglobinemia

Front 68

Which immunodeficiency presents with severe pyogenic infections early in life?

Back 68

Hyper-IgM syndrome

Front 69

Which immunodeficiency presents with sinus and lung infection, milk allergies and diarrhea?

Back 69

Selective IgA deficiency

Front 70

Which immunodeficiency presents with increased rissk of autoimmune disease, lymphoma and sinopulmonary infections?

Back 70

CVID

Front 71

Which immunodeficiency presents with tetany, recurrent viral/fungal infections and congenital CV defects?

Back 71

Thymic Aplasia (DiGeorge)

Front 72

Which immunodeficiency presents with disseminated mycobacterial infections?

Back 72

IL-12 receptor deficiency

Front 73

Which immunodeficiency presents coarse facies, staph abscesses, increased IgE and eczema?

Back 73

Hyper-IgE syndrome (Job's)

Front 74

Which immunodeficiency presents with candida of skin and mucous membranes?

Back 74

Chronic mucocutaneous candidiasis

Front 75

Which immunodeficiency presents w/ Thrombocytopenic purpura, Infections and Eczema?

Back 75

Wiskott-Aldrich syndrome

Front 76

Which immunodeficiency presents with recurrent bacterial infections, absent pus formation and delayed seperation of umbilicus?

Back 76

Leukocyte adhesion deficiency type I

Front 77

Which immunodeficiency presents with recurrent pyogenic infections by staph and strep, partial albinism and peripheral neuropathy?

Back 77

Chediak-Higashi syndrome

Front 78

Which immunodeficiency presents with increased susceptibility to catalase-positive organisms?

Back 78

Chronic granulomatous dz

Front 79

Which immunosuppressant inhibits calcineurin --> prevention of IL-2 production?

Back 79

Cyclosporine

Front 80

Which immunosuppressant acts by binding FK-protein --> inhibition of IL-2?

Back 80

Tacrolimus

Front 81

Which immunosuppressant acts by inhibiting mTOR --> inhibiting T-cell proliferation?

Back 81

Sacrolimus

Front 82

Which immunosuppressant acts by interfering with the synthesis of nucleic acids?

Back 82

Azathioprine

Front 83

Which immunosuppressant acts by binding to CD3 on surface of T cells?

Back 83

Muromonab-CD3 (OKT3)

Front 84

Which cytokine is used to treat MS?

Back 84

INF-beta

Front 85

Which cytokine is used to treat chronic granulomatous dz?

Back 85

INF-gamma

Front 86

Which cytokine is used to treat Hepatitis, Kaposi's, leukemias and malignant melanoma?

Back 86

INF-alpha

Front 87

What dz is treated with Oprelvekin?

Back 87

Thrombocytopenia

Front 88

What is the target and clinical use for Infliximab?

Back 88

TNF-alpha --> Rx Crohn's RA, psoriatic arthritis, ankylosing spondylitis

Front 89

What is the target and clinical use for Rituximab?

Back 89

CD20 --> Rx B-cell non-Hodgkin's lymphoma

Front 90

What is the target and clinical use for Omalizumab?

Back 90

IgE --> Rx asthma

Front 91

What is the target and clinical use of Abciximab?

Back 91

Glycoprotein IIb/IIIa --> Rx cardiac ischemia in unstable angina