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7 Cards in this Set
- Front
- Back
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Cyclosporine (MOA, Use, SE)
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MOA: Binds cyclophilins; Inhibits calcineurin to block T cell differentiation and IL2 production
Clinical Use: Organ Rejection SE: - Nephrotoxicity - Gout - Grapefruit --> inc cyclosporine |
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Tacrolimus (MOA, Use, SE)
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MOA: Binds FK-binding protein; Inhibits calcineurin to block T cell differentiation and IL2 production
Clinical Use: Immunosuppressive in organ transplant SE: Nephrotoxicity; Hyperglycemia |
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Sirolimus (MOA, Use, SE)
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MOA: Inhibits mTOR --> inhibit T cells
Use: Immunosuppression after kidney transplant SE: no Nephrotoxicity; Hyperlipidemia |
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Azathioprine (MOA, Use, SE)
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MOA: Antimetabolite; precursor to 6-mercaptopurine; interfere w/ nucleic acid syntehsis
Use: Kidney transplant SE: Metabolized by Xanthine oxidase; toxic effects may be inc by allopurinol |
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Muromonab-CD3 (MOA, Use, SE)
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MOA: Monoclonal AB binds CD3
Use: Immunosuppresion after kidney transplant SE: Cytokine release syndrome |
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Daclizumab (MOA)
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MOA: IL-2 Receptor antagonist
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Micophenoalate (MOA, Use, SE)
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MOA: Inhibit purine synthesis
- inhibits inosine monophosphate dehydrogenase --> prevents guanine --> can't make more B and T cells which are rapidly turned over Use: transplants and lupus nephritis Toxicity: Lymphoma and Teratogen |
