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32 Cards in this Set

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autoimmune d/o assoc'd with anti-dsDNA
SLE
anti-Smith
SLE
antihistone
drug-induce lupus (procainamide, hydralazine?)
anti-centromere
scleroderma (CREST, limited cutaneous, pumonary HTN)
anti-Scl-70
scleroderma, diffuse
antimitochondrial
primary biliary cirrhosis
antigliadin
celiac dz
anti-basement membrane
Goodpasture's
anti-epithelial cell
pemphigus vulgaris (desmoglein 3!)
antimicrosomal
Hashimoto thyroiditis
Anti-Jo-1
polymyositis, dermatomyositis
HLA-B8
Graves' dz, celiac sprue
HLA-DR2
MS, hay fever, SLE, Goodpasture's
HLA-DR4
RA, diabetes type 1
HLA-DR5
pernicious anemia, Hashimoto thyroiditis
HLA-DR7
steroid responsive nephrotic syndrome
Name the cytokine:secreted by macrophages, stimulates just about everything, endogenous pyrogen
IL-1
which cytokine stimulates growth of helper and cytotoxic T cells
IL-2
which cytokine supports growth and differentiation of BM stem cells
IL-3 (secreted by activated T cells)
which cytokine promotes growth of B cells and enhances class switching of IgE, IgG?
IL-4
which cytokine enhances class switching of IgA?
IL-5 (also promotes differentiation of B cells, stimulates production and activation of eosinophils)
which cytokine stimulates activation and production of eosinophils?
IL-5
which cytokine stimulates production of acute phase reactants and immunoglobulins?
IL-6
which interleukin is one of the MAJOR chemotactic factors for PMNs?
IL-8 (also, C5a)
which cytokine stimulates Th2 and inhibits Th1?
IL-10 (secreted by Th2 cells)
IL-10
secreted by Th2 cells; stimulates Th2, inhibits Th1
which cytokine activates NK cells and Th1 cells?
IL-12 (secreted by macrophages, B cells)
who is the "anticytokine" that inhibits growth and activity of T cells, counteracts effects of inflammatory cytokines, and stimulates wound healing?
TGF-beta
which cytokine increases IL-2 receptor synthesis by Th cells, and increased B cell proliferation?
TNF-alpha (also attracts and activates PMNs, stimulates dendritic cell migration to lymph nodes)
which cytokine is NOT produced in Job's syndrome--> "cold" staph abscesses
gamma-IFN (secreted by Th1 cells, stimulates macrophages)
what are the 2 signals required for activation of helper T cells?
1) foreign Ag on MHC II recognized by TCR on Th cell; 2) costim by B7-CD28
what are the 2 signals required for activation of cytotoxic T cells
1) endogenously synthesized proteins on MHC I recognized by TCR; 2) IL-2 from Th cell activates cytotoxic cell