First Aid Drugs - Hiv Drugs

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protease inhibitors name them

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never (NAVIR) tease a pro-tease inhibitor. All end in "navir"

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protease inhibitor MOA

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inhibits assembly of new virus by inhibiting protease in progeny virus

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protease inhibitor toxicity

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GI intolerance (nausea, diarhea), hyperglycemia, lipodystrophy, thrombocytopenia (indinavir)… metabolic syndrome

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reverse transcriptase inhibitors

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nucleoside: zidoVUDINE (AZT), staVUDINE (d4T), lamiVUDINE, abacavir, zalcitabine (ddC), didanosine (3TC). Non-nucleosides: Never deliver nucleosides. Nevirapine, efavirenz, delavirdine

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reverse transcriptase inhibitors MOA

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preferentially inhibits HIV reverse transcriptase. Prevents incorporation of viral genome into host DNA

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reverse transcriptase toxicity

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BM supression (neutropenia, anemia), peripheral neuropathy, LACTIC ACIDOSIS (nucleosides), rash (non nucleosides), megaloblastic anemia (didovudine

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reverse transcriptase inhib clinical use

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HAART. Combination tx w/ protease inhibitors and reverse transcriptase inhibitors. Started when pts have CD4<500 or high viral load. AZT used in preg to reduce transmission risk

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interferons mechanism

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block various stages of viral RNA and DNA syn. Induces ribonuclease that degrades viral mRNA.

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interferon clinical use

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IFN alpha. Chronic hepatitis B and C, Kaposi sarcoma. IFN beta - MS. IFN gamma - NADPH oxiodase deficiency

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interferon toxicity

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neutropenia, depression

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pleconaril MOA

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prevents attachment of poliovirus to cell