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19 Cards in this Set
- Front
- Back
- 3rd side (hint)
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amphotericin MOA |
amphoTEARicin. binds ergosterol, forms memb pores, allows leakage of electrolytes and disrupts homeostasis
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amphotericin clinical use
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wide spectrum of SYSTEMIC mycosis: cryptococcus, blastomyces, coccidioides, aspergillus, histoplasma, candida, mucor. Intrathecally for fungal MENINGITIS does not X-BBB |
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amphotericin toxicity
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shake and bake: fever/ chills, AMPHOTERRIBLE: hypotension, nephrotox, arrythmias, anemia, IV phebitis. HYDRATION REDUCES NEPHROTOXICITY |
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nystatin MOA
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binds ergosterol, disrupts fungal memb. TOO TOXIC FOR SYSTEMIC USE
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nystatin clinical use
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SWISH AND SWALLOW for oral candidiasis (thrush); topical for diaper rash or vaginal candidiasis
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azoles MOA
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inhibits fungal steroid (ergosterol) syn
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azoles clinical use
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SYSTEMIC mycoses. Fluconazole for cryptococcal meningitis in AIDS pts. Candidal infections of all types. ITRACONAZOLE for blastomyces, coccidioides, histoplasma, , hypercortisolism. CLOTRIMAZOLE and MICONAZOLE for topical fungal infections. |
None
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azole toxicity |
Testosterone hormone syn inhibition (gynecomastia, esp with/ KETOCONAZOLE), liver dysfunction (inhibits P450). |
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flucytosine MOA
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inhibits DNA syn by conversio nto flurouracil, competes w. uracil
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flucytosine clinical use
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SYSTEMIC FUNGAL INFECTIONS IN COMBO W/ AMPHOTERICIN B. |
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flucytosine toxicity
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N/V, diarrhea, BM supression |
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ECHINOCANDINS: caspofungin, micafungin, andulafungin: MOA |
inhibits cell wall syn (by inhibiting enzyme that makes beta-glucan) |
None
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caspofungin clinical use |
INVASIVE ASPERGILLOSIS!! CANDIDA |
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caspofungin toxicity
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GI, flushing by histamine release. |
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terbinafine MOA
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inhibits fungal enz squalene epoxidase
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terbinafine clinical use
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tx dermatophytoses (esp onchomycosis) SIDE EFFECTS: GI upset, headaches, taste disturbances. |
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griseofulvin MOA
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interferes w. microtubile fxn. Disrupts mitosis. Deposits in keratin containing tissue (nails)
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griseofulvin clinical use
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oral tx of superficial infection. Inhibits growth of dermatophytes (tinea, ringworm)
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griseofulvin tox
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teratogenic, carcinogenic, confusion, HA, increased P450 (warfarin)
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