Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/19

Click to flip

19 Cards in this Set

  • Front
  • Back
  • 3rd side (hint)
amphotericin MOA
amphoTEARicin. binds ergosterol, forms memb pores, allows leakage of electrolytes and disrupts homeostasis
amphotericin clinical use
wide spectrum of SYSTEMIC mycosis: cryptococcus, blastomyces, coccidioides, aspergillus, histoplasma, candida, mucor. Intrathecally for fungal MENINGITIS does not X-BBB
amphotericin toxicity
shake and bake: fever/ chills, AMPHOTERRIBLE: hypotension, nephrotox, arrythmias, anemia, IV phebitis. HYDRATION REDUCES NEPHROTOXICITY
nystatin MOA
binds ergosterol, disrupts fungal memb. TOO TOXIC FOR SYSTEMIC USE
nystatin clinical use
SWISH AND SWALLOW for oral candidiasis (thrush); topical for diaper rash or vaginal candidiasis
azoles MOA
inhibits fungal steroid (ergosterol) syn
azoles clinical use
SYSTEMIC mycoses. Fluconazole for cryptococcal meningitis in AIDS pts. Candidal infections of all types. KETOKONAZOLE for blastomyces, coccidioides, histoplasma, candida albicams, hypercortisolism
None
azole toxicity
hormone syn inhibition (gynecomastia), liver dysfunction (inhibits P450), fever, chills
flucytosine MOA
inhibits DNA syn by conversio nto flurouracil, competes w. uracil
flucytosine clinical use
SYSTEMIC FUNGAL INFECTIONS
flucytosine toxicity
N/V, diarrhea, BM supression
caspofungin MOA
inhibits cell wall syn (by inhibiting enzyme that makes beta-glucan)
None
caspofungin clinical use
INVASIVE ASPERGILLOSIS!!
caspofungin toxicity
GI, flushing
terbinafine MOA
inhibits fungal enz squalene epoxidase
terbinafine clinical use
tx dermatophytoses (esp onchomycosis)
griseofulvin MOA
interferes w. microtubile fxn. Disrupts mitosis. Deposits in keratin containing tissue (nails)
griseofulvin clinical use
oral tx of superficial infection. Inhibits growth of dermatophytes (tinea, ringworm)
griseofulvin tox
teratogenic, carcinogenic, confusion, HA, increased P450 (warfarin)