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12 Cards in this Set
- Front
- Back
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What is the mechanism of actino of Penicillin, ampicillin, ticarcillin, pipercillin, imipenem, aztreonam and cephalosporins?
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Block cell wall synthesis by inhibition of peptidoglycan cross-linking
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What is the mechanism of Vancomycin and Bacitracin?
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They block peptidoglycan synthesis
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What is the mechanism of action of Polymyxins?
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They disrupt bacterial cell membranes
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How do sulfonomides and trimethroprims work?
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They block NUCLEOTIDE synthesis
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How do Quinolones work?
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Block DNA Topoisomerases
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How does Rifampins work?
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Block mRNA synthesis
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How do Chloramphenicol, macrolides, clindamycins, streptogramins, and linezolids work?
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Block 50S subunit
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How do Aminoglycosides and Tetracyclines work?
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Block 30S subunit
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What are the Bacteriostatic antibiotics?
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ECS TTC
Erythromycine Clindamycin Sulfamethoxazole Trimethoprim Tetracycline Chloramphenicol |
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What are the Bacteriocidal antibiotics?
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V F P
A C M Very finely proficient at cell murder Vancomycin Flouroquinolones Pennicillin Aminoglycosides Cephalosporins Metranidazole |
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Penicillin
1. Mechanism 2. Clinical use 3. Toxicity |
1. Bind PCP (Transpeptidases) & Activate autolytic enzymes
2. Gram + : R&C Gram - : C Spirochetes |
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Penicillinase-Resistant PCNs
Methicillin Nafcillin Dicloxacillin Mechanism Clinical Use Toxicity |
Mechanism: Binds PBPs, activates autolytic enzymes
Clinical use - Staph aureus infectious (but NOT MRSA) Toxicity: Hypersensitivty hemolytic anemia |
