First Aid 2012: Heme/onco

Front 1

>???

Back 1

neutrophil (normal)

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What disease or condition?

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b12 or folate (hypersegmented neutrophil)

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what CD is necessary for t-cell activation?

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CD28 (costimulatory signal)

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hemophilia A deficiency
HEMOPHILIA B

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factor 8- A
factor 9- B

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antithrombin inhibits what

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thrombin and factors 7a, 9a, 10a, 11a, 12a

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what are the microcytic anemias

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IDA
ACD(progresses from normocytic)
Thalassemais
Lead poisoning
Sideroblastic

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what is plummer-vinson syndrome triad?

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IDA, esophageal web, and atrophic glossitis

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alpha thalassemia present in what populations normally

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asian or african

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Hb barts gamma 4 is also known as

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hydrops fetalis

Front 10

what condition or disease

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liver disease, abetalipoproteinemia

acanthocytes

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What disorder(s)

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thalassemias, anemia of chronic disease, Lead poisoning!

Front 12

What disorder or disease?

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G6PD def

bite cells

Front 13

What disorder or disease

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DIC, TTP/HUS, traumatic hemolysis

Front 14

What disorder or diseases

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HbC disease, Asplenia, Liver disease, Thalassemia

target cells

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What disorder or disease

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howell jolly bodies

functional hyposplenia, or asplenia

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treatment for Pb poisoning in kids

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succimer

Front 17

Lead poisoning: what does lead inhibit?

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ferrocheletase and ALA dehydratase

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treatment for sideroblastic anemia

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pyridoxine b6

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defect in sideroblastic anemia

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gamma aminolevulinic acid synthase gene

x-linked

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methylmalonic acid levels in b12 vs folate deficiency

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normal in folate deficiency...increased in b12

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decreased levels of what in g6pd deficiency

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glutathione (x-linked)

Front 22

labs for paroxysmal nocturnal hemoglobinuria

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increased urine hemosiderin

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tx for sickle cell anemia

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hydroxyurea, and BM transplantation

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hereditary spherocytosis tx

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splenectomy

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macroangiopathic hemolytic anemia causes

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prosthetic heart valves and aoritc stenosis

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you see a really high % transferrin saturation level, you should think

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hemochromatosis, moreso than lead

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rate-limiting step in heme synthesis

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gamma-aminolevulinic acid synthase (sideroblastic anemia)

Front 28

bernard soulier disease defect

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GPIb

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glanzmann's thrombasthenia defect

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GPIIB/IIIA

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defect in TTP

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ADAMTS13 (decreases the degradation of vWF multimers)

Front 31

list the different types of hodgkins lymphoma from best prognosis to worst

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nodular sclerosing
mixed cellularity
Lymphocyte predominant
lymphocyte deplted

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you see a really high % transferrin saturation level, you should think

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hemochromatosis, moreso than lead

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rate-limiting step in heme synthesis

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gamma-aminolevulinic acid synthase (sideroblastic anemia)

Front 34

bernard soulier disease defect

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GPIb

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glanzmann's thrombasthenia defect

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GPIIB/IIIA

Front 36

defect in TTP

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ADAMTS13 (decreases the degradation of vWF multimers)

Front 37

list the different types of hodgkins lymphoma from best prognosis to worst

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Lymphocyte predominant
nodular sclerosing
mixed cellularity
lymphocyte deplted

Front 38

CD origin for reed sternberg cells

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CD30+ and CD15+

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protein C or S defiency leads to inability to inactivate what factors

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V and VIII

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treatment for vWF disease

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DDAVP (desmopressin)

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???

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burkitts lymphoma (starry sky...sure)

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translocation in burkitts

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8;14)

c-myc moves next to heavy chain Ig gene

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most common non-hodkins lymphoma in adults

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diffuse large b-cell lymphoma

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mantle cell lymphoma translocation

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t(11;14), leads to overexpression of cyclin D

also CD5+

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follicular lymphoma translocation

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t(14;18) bcl-2 underexpression

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findings in multiple myeloma

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hyperCalcemia. Renal insufficiency, Anemia, Bone lytic lesions/back pain

CRAB

Front 47

M spike on electrophoresis

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multiple myeloma or waldenstroms syndrome(hyperviscosity, no bone lesions)

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treat toxicity of tPA or urokinase with

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aminocraproic acid (inhibits fibrinolysis)

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clopidogrel MOA

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blocks ADP receptors. inhibits fibrinogen binding by preventing expression of GpIIb/IIIa

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cilostazol MOA

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PDE III inhibitor...increase cAMP in platelets, decrease aggregation. vasodilator

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Abciximab MOA

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antibody that binds to IIb/IIIa

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bleomycin works at what stage of cell

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G2

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etoposide works at what stage of cell cycle

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G2 and S

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Antimetabolites (MTX, 5-FU) work at what stage of cell cycle

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S

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Vincristine and Vinblastine work at what stage of cell cycle

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M phase

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how do you reverse MTX

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leucovorin(folinic acid)

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MTX MOA

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folic acid inhibitor

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what antimetabolite can't be given with allopurinol

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6-MP...metabolized by xanthine oxidase

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what antimetabolite is a purine analog

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6-MP

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5-FU MOA

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pyrimidine analog, covalently complexes folic acid...inhibits thymidylate synthase

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what do you use in 5-FU overdose

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thymidine

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Cytarabine MOA

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pyrimidine analog... inhibits DNA polymerase

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MTX MOA

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folic acid analog...inhibits dihydrofolate reductase