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7 Cards in this Set

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What happens when you change the setpoint of the hypothalamis thermostat?
when dog placed in a 10 degree room, the setpoint shifts to the right. at the body temp now below the lower critical setpoint, the hypothalamus is warned to shiver so that the core body temp won't change.
Changing the sensitivity of the hypothalamic thermostat
changed the thermostats sensitivity so that when the body temp (of a seal) drops, the response will be greater than normal
Fever
three stages:
chill
fever
break
does a fever breakdown or reprogram your thermostat?
reprogams it. Curve shifts to the right with infetion. you will start to shiver b/c below set point. body temp increases to the thermal neutral zone of shifted curve. thermoregulate at a higher temperature. at fever break, the curve shifts back to normal but you're body temp hasn't decreased yet so you sweat.
mechanisms of fever generation
-bacteria/fungi/ virus
-exogenic pyrogen -> lipopolysaccharide W
-WBC
-interleukin-1
-hypothalamus
-prostaglandin E-1
-hypothalamus
-fever
adaptive significance of fever...
experiment on desert iguana (an actotherm but can get behavioral fever). injected with a fever inducer and body temp raised to 41. now, give aspirin to some. those given aspirin died -> shows that fevers serve a purpose
What does aspirin inhibit the release of?
prostaglandin E1