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12 Cards in this Set
- Front
- Back
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define fibromyalgia.
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a poly-symptomatic syndrome whose hallmarks include chronic widespread pain, fatigue, and sleep disturbance
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define fibromyalgia according to the American college on rheumatology.
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widespread pain for at least three months as the presence of all of the following: pain on the right and left sides of the body, pain above and below the waist, pain in the axial skeleton
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what are known physical findings in fibromyalgia?
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elevated substance P, pain related to NMDA receptor function, no known pathology in the muscles or bones, multiple neuroendocrine disturbances, sympathetic hyperactivity, over active CRH neurons
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the phenomenon of central sensitization depends on plasticity of function of what?
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NMDA receptors
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what part of the body is characterized by high densities of receptors for glutamate, NE, CRH, and glucocorticoids and is thus probably has something to do with fibromyalgia?
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hippocampus
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what is the thought on how the hippocampus may be affected if traumatic events occurred and we were so stressed out?
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it would atrophy bc it gets info from the LC, amygdala, and paraventricular nu about stress and then acts like an internal valium and releases GABA to calm us down…
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how are NMDA receptors important in fibromyalgia?
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they have to do with memory, pain, and stress
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what does dopamine have to do with stress and fibromyalgia?
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changes in hippocampal NMDA receptor function have the potential to produce an entire spectrum of neuropsychiatric disorders by controlling mesolimbic dopamine activity
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stress can affect what?
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affeect, nociception, energy, cognition, and motor function
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stress can result in increased or decreased NMDA sensitivity. What are the manifestations of each?
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increase is hyperalgesia, depression, slowed cognition, hypermotoric, anhedonia. Decreased is hypoalgesia, mania, hallucinations, motor retardation, increased libido
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compare and contrast schizophrenia and fibromyalgia in terms of responses to stress and DA and NMDA activity.
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fibromyalgia is increased NMDAR sensitivity, increased tonic DA activity, and decreased phasic DA release. Schizo is the opposite of all that.
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what are the medication types for fibromyalgia?
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beta blockers, tricyclics, micronized progesterone, dopamine promoters, neuromodulators, histamine 2 blockers, stress modulators, thyroid support, adrenal support
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