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10 Cards in this Set
- Front
- Back
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hemostasis
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the arrest of bleeding, either by the physical properties of vasoconstriction and coagulation or by surgical means
interruption of blood flow through any vessel or to any anatomical area |
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major events in hemostasis
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formation of platelet plug (primary)
formation of insoluble fibrin clot (secondary) resolution (clot retraction and fibrinolysis) |
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main components of hemostasis
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blood vessels
platelets coagulation/ fibrinolytic sys |
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key fxns in hemostasis
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structural
- interactions w/ platelets and coagulation factors neuromechanical - vasoconstriction biochemical - endothelial synthesis and metabolism of bioactive molecules |
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coag and fibrinolytic systems have pathways for
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Rapid formation of an insoluble fibrin clot when needed
- Eventual elimination of the clot Prevention of inappropriate clotting |
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blood vessel fxn in hemostasis
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structural framework for hemostasis (subendothelial collagen)
neuromechanical (vasoconstriction) biochemical (endothelial synthesis and metabolism of key regulatory molecules) |
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the coagulation system involves interconnected _______ pathways
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pro-coag
anti-coag fibrinolytic |
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activation of coagulation cascade eventually results in _____.
what is the fxn of that product? |
thrombin
converts fibrinogen to fibrin |
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platelet production regulated mostly by
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TPO
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platelet lifespan
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1 wk
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