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What are the layers of the epidermis from the surface to the base?
Californians Like Girls in String Bikinis: - Stratum Corneum (keratin) - Stratum Lucidum - Stratum Granulosum - Stratum Spinosum (spines = desmosomes) - Stratum Basale (stem cell site)

Californians Like Gorillas in Small Batches:
- Stratum Corneum (keratin)
- Stratum Lucidum
- Stratum Granulosum
- Stratum Spinosum (spines = desmosomes)
- Stratum Basale (stem cell site)
What is Layer A (epidermis)?
What is Layer A (epidermis)?
Stratum Corneum (keratin)
Stratum Corneum (keratin)
What is Layer B (epidermis)?
What is Layer B (epidermis)?
Stratum Lucidum
Stratum Lucidum
What is Layer C (epidermis)?
What is Layer C (epidermis)?
Stratum Granulosum
Stratum Granulosum
What is Layer D (epidermis)?
What is Layer D (epidermis)?
Stratum Spinosum (spines = desmosomes)
Stratum Spinosum (spines = desmosomes)
What is Layer E (epidermis)?
What is Layer E (epidermis)?
Stratum Basale (stem cell site)
Stratum Basale (stem cell site)
What are the types of junctions between epithelial cells?
Lateral edge: - Tight junction / Zonula Occludens - Adherens junction / Zonula Adherens - Desmosome / Macula Adherens - Gap junction Basolateral edge: - Hemidesmosome - Integrins
Lateral edge:
- Tight junction / Zonula Occludens
- Adherens junction / Zonula Adherens
- Desmosome / Macula Adherens
- Gap junction

Basolateral edge:
- Hemidesmosome
- Integrins
Which type of epithelial cell junction prevents paracellular movement of solutes? What is it composed of?
Tight Junctions / Zonula Occludens - Composed of Claudins and Occludins
Tight Junctions / Zonula Occludens
- Composed of Claudins and Occludins
Which type of epithelial junction is located below the tight junctions, forming a "belt"? What is it composed of?
Adherens Junctions / Zonula Adherens - Composed of actin cytoskeletons of adjacent cells with CADhereins (Ca2+ dependent ADhesion proteins)
Adherens Junctions / Zonula Adherens
- Composed of actin cytoskeletons of adjacent cells with CADhereins (Ca2+ dependent ADhesion proteins)
Which type of epithelial junction provides structural support? What is it composed of?
Desmosomes / Macula Adherens - Keratin interactions - Desmoplakin
Desmosomes / Macula Adherens
- Keratin interactions
- Desmoplakin
Which type of epithelial junction permits electrical and chemical communication between cells? What is it composed of?
Gap Junction - Channel proteins called Connexons
Gap Junction
- Channel proteins called Connexons
Which type of epithelial junction connects keratin in basal cells to the underlying basement membrane?
Hemidesmosomes
Hemidesmosomes
Which type of epithelial junction binds to collagen and laminin in the basement membrane?
Integrins - Membrane proteins that maintain the integrity of the basolateral membrane
Integrins
- Membrane proteins that maintain the integrity of the basolateral membrane
What failure of epithelial cell junctions leads to metastasis?
Loss of E-cadherin
Loss of E-cadherin
What failure of epithelial cell junctions leads to Pemphigus Vulgaris?
Desmosomes / Macula Adherens
Desmosomes / Macula Adherens
What failure of epithelial cell junctions leads to Bullous Pemphigoid?
Hemidesmosomes (remember, they are down "bullow")
Hemidesmosomes (remember, they are down "bullow")