Fa Pharm: Endocrine, Immuno, Ca Rxs

Front 1

Endocrine Drugs: Hydrocortisone, prednisone, triamcinolone, dexamtasone, bleclomethasone are examples of what kind of drugs?

Back 1

Glucocorticoid

Front 2

Endocrine Drugs: Glucocorticoids decrease the production of ___ and ____

Back 2

Leukotrienes and prostanglandins

Front 3

Endocrine Drugs: To treat Addison's disease, inflammation, immune suppression, asthma, use ____

Back 3

Glucocorticoids

Front 4

Endocrine Drugs: An important side-effect of Glucocortioid usage is ____

Back 4

Iatrogenic Cushing's Syndrome

Front 5

Endocrine Drugs: Buffalo hump, moon facies, truncal obesity, muscles wasting, thin skin, easy bruisability, osteoporosis, adrenocortical atrophy, peptic ulcers characterize what syndrome?

Back 5

Cushing's Syndrome

Front 6

Reproductive Drugs: Which two drugs inhibit cGMP phosphodiesterase, leading to smooth muscle relaxation in the corpus cavernosum and penile erection?

Back 6

Sildenafil and Verdenafil --they fill the penis

Front 7

Reproductive Drugs: What class of drugs are used tto treat erectile dysfunction

Back 7

cGMP Inhibitors

Front 8

Reproductive Drugs: CGMP inibitors taken with ____have a high risk of liofe-threeatening hypotension

Back 8

nitrates

Front 9

Reproductive Drugs: Which drugs is a partial agonist of estrogen recpetors in the pituitary gland, stimulating increase in LH and FSH, which stimulates ovulation to treat infertility

Back 9

clomiphene

Front 10

Reproductive Drugs: Clomiphene's side effects include:

Back 10

Hotflashes, ovarian enlargment, multiple simultaneous pregnancies, visual disturbances

Front 11

Reproductive Drugs: What abortifacient is a competitite inhibitor of preogestins at progesterone recpetor and may lead to heavy menstrual-like bleeding?

Back 11

Mifepristone (RU486)

Front 12

Reproductive Drugs: The advantage of this drug is that it is reliable, decreases incidence of ectopic pregnancy, decreases risk of pelvic infections, and regulates menses; however it also puts you in a hypercoagulable stat and may increase your trigylcerides, weight, and blood pressure

Back 12

Oral Contracpetices - syntheitc progestins/estrogen

Front 13

Rheumatologic Drugs: ____is converted to uric acid which leads to gout

Back 13

Xanthine (converted from excess purines)

Front 14

Rheumatologic Drugs: This drug depolymerizes microtubules, impairing leukocyte chemotaxis and degranulation, and used to treat acute gout

Back 14

Colchicine

Front 15

Rheumatologic Drugs: This drugs inhibits reabsorption of uric acid and used to treat chronic gout

Back 15

Probenecid

Front 16

Rheumatologic Drugs: This drug is used to treat chronic gout, but also inhbits secretion of penicillin

Back 16

Probenecid

Front 17

Rheumatologic Drugs: This drugs inhibits xanthine oxidase decreasing the conversion fo xanthine to uric acid

Back 17

Allopurinol

Front 18

Oncologic Drugs: What are the cell cycle specific oncologic drugs

Back 18

antimetabolites, plant alkaloids, stroid hormones, bleomycin, paclitaxel, etoposide

Front 19

Oncologic Drugs: What are the cell cycle Nonspecific oncologic drugs?

Back 19

alkylating agents and antibiotics

Front 20

Oncologic Drugs: ____is an S-phase-specific anti-metabolite that is an folic acid analog that inhibits dihydrofolate reducate decreasing dTMP(thymidine and purines) and decreaing DNA/prtein synthesis.

Back 20

Methotrexate

Front 21

Oncologic Drugs: ____is an S-phase-specific anti-metabolite that is a pyrmidine analog which complexed to folic acid, inhibiting thymidylate synthase, decreasing dTMP and decreasing DNA/protein synthesis

Back 21

5-Fluorouracil (5-FU)

Front 22

Oncologic Drugs: Myelosuppression by methotrxate is reversible with ____

Back 22

leucovorin (folinic acid) rescue

Front 23

Oncologic Drugs: Which drug blocks purine synthesis and is used to treat leukemias, lymphomas (not CLL or Hodgkins)

Back 23

6-mercaptopurine (6-MP)

Front 24

Oncologic Drugs: Which drug alkylates DNA and is used to treat CML?

Back 24

Busulfan

Front 25

Oncologic Drugs: Which drug inhibits DNA polymerase and is used to treat AML?

Back 25

cytarabine

Front 26

Oncologic Drugs: This drug used to treat Leukemias and Lymphomas is metaboilized by xanthine oxidase

Back 26

6-mercaptopurine (6-MP)

Front 27

Oncologic Drugs: Used to treat leukemias, lymphomas, choricarcinoma, sacromas, rheumatoid arthritis, psoriasis, and can be an abortifacient; it may lead to myelosuppression

Back 27

Methotrexate

Front 28

Oncologic Drugs: Used to treat colon cancer and other solid tumors, basal cell carcinoma (topically)

Back 28

5-Fluorouracil (5-FU)

Front 29

Oncologic Drugs: Myelosuppression by 5-FU is ______

Back 29

Not reversible

Front 30

Oncologic Drugs: This drug used to treat AML may lead to leukopenia, thrombocytopenia, megaloblastic anemia?

Back 30

cytarabine

Front 31

Oncologic Drugs: This drugs used to treat CML may lead to pulmonary fibrosis and hyperpigmentation?

Back 31

Busulfan

Front 32

Oncologic Drugs: ____is an alkylating agent acivated by liver that covalently x-links DNA at guanine N-7, and is used to treat non-hodgkin's lymphoma, breast/ovarian carcinomas

Back 32

cyclophosphamides

Front 33

Oncologic Drugs: ____ alkylates DNA after bioactivation and can cross the BBB and treats brain tumors (glioblastoma multiforme)

Back 33

Nitrosoureas (Carmustine, lomustine, semustine, streptozocin)

Front 34

Oncologic Drugs: ____acts like an alkylating agent, x-linking via hyrdolysis of Cl and platinum; used to treat testicular, bladder, lung carcinomas

Back 34

Cisplatin

Front 35

Oncologic Drugs: This alkylating agent can cause myelosuppression and hemorhagic cystitis

Back 35

cyclophosphamides

Front 36

Oncologic Drugs: This combination of drugs is used to treat Hodgkin's and myelomas, sarcomas, and solid tumors (breast, ovary, lung)

Back 36

ABVD: Adriamycin, Bleomycin, Vinblastine, Dacarbazine

Front 37

Oncologic Drugs: ____noncovalently intercalates in DNA, creating breaks to decrease replication and transcription

Back 37

Doxorubicin (adriamycin)

Front 38

Oncologic Drugs: ____intercalates DNA strands and induces free radical fromation which causes strand breaks

Back 38

Bleomycin, Dactinomycin

Front 39

Oncologic Drugs: Which drugs causes cardiotoxicity, alopecia, and myelosuppression?

Back 39

Doxorubicin (adriamycin)

Front 40

Oncologic Drugs: Which drug is used to trat oat cell carcinoma of the lung and prostate/testicular carcinoma?

Back 40

Etoposide

Front 41

Oncologic Drugs: This combination of drugs is used to treat lymphoma, CLL, Hodgkin's, Wilm's tumor, choriocarcinoma

Back 41

MOp (Mustargen, Oncovin (Vincristine), Procarbazine (Matulane), Prednisone)

Front 42

Oncologic Drugs: Which glucocorticoid may trigger apoptosis and may even work on nondividing cells

Back 42

Prednisone

Front 43

Oncologic Drugs: This drug is a G2-phase specific inhibitor of Topisiomerase II, leaving double strand breaks in DNA following DNA replication

Back 43

Etoposide

Front 44

Oncologic Drugs: This drug used to treat testicular cancer and lymphomas may cayse pulmonary fibrosis, skin chnages, and myelosuppression

Back 44

Bleomycin, Dactinomycin

Front 45

Oncologic Drugs: This drugs used as an immunosuppressant and in lymphomas may cause acne, osteoporosis, hypertension, peptic ulcers, hyperglycemia, psychosis?

Back 45

Prednisone

Front 46

Oncologic Drugs: ____is an estrogen receptor mixed agonist/antagonist that blocks the binding of estrogen to ER+ cells.

Back 46

Tomoxifen/Raloxifene

Front 47

Oncologic Drugs: ____is n M-phase-specific alkaloid that binds to tubulin and blocks polymerization of microtubules, preventing spindle formation

Back 47

Vincristine and Vinblastine

Front 48

Oncologic Drugs: ____is an M-phase-specific agen that binds to tubulin and hyperstabilizes the polymerized microtubules, so that the mitotic spindle cannot break down

Back 48

Paclitaxel

Front 49

Oncologic Drugs: What drugs is used to treat breast cancer, but may increas the risk of endometrial carcinomas and hot flashes

Back 49

Tomoxifen

Front 50

Oncologic Drugs: Side-effects of Vinblastine include….

Back 50

VinBASTine BLASTs Bone Morraow, causing myelosupression, as well as neurotoxicity and paralutic ileus.

Front 51

Oncologic Drugs: Side effects of Paclitaxel include….

Back 51

Myelosupression and hypersensitivity

Front 52

Immunosuppressants and Cytokine Therapy: This drug binds to cyclophilins, blocking differentiation and activation of T cells mainly by inhibiting IL2 production

Back 52

cyclosporine

Front 53

Immunosuppressants and Cytokine Therapy: This antimetabolite derivative of 6-mercaptopurine interferes with the metabolism and synthesis of nucleic acid, therefore toxic to proliferating lymphocytes

Back 53

azathioprine

Front 54

Immunosuppressants and Cytokine Therapy: This potent immunosuppressive drug binds to the FK-binding protein and inhibits secretion of IL2 and other cytokines

Back 54

tacrolimus (FK506)

Front 55

Immunosuppressants and Cytokine Therapy: This drug is used to suppress organ rejection after transplantation, but may predispose patient to viral infections and lymphoma

Back 55

cyclosporine

Front 56

Immunosuppressants and Cytokine Therapy: Azaothioprine is used to in what setting?

Back 56

Kidney transplants, autoimmune disorders (glomerulonephritis, hemolytic anemia)

Front 57

Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- Aldesleukin (interleukin-2) is used for?

Back 57

Renal cell carcinoma, metastatic melanoma

Front 58

Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- Erythropoietin (epoetin) is used for?

Back 58

anemia

Front 59

Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- Filgrastim is used for?

Back 59

Recovery of Bone Marrow; it is a granulocyte colony stimulating factor

Front 60

Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- alpha interferon is used for?

Back 60

Hep B/C, Kaposi's sarcoma, leukemia, malgnant melanoma

Front 61

Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- beta interferon is used for?

Back 61

Multiple Sclerosis

Front 62

Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- gamma interferon is used for?

Back 62

Chronic Granulomatous disease

Front 63

Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- oprelvekin (interleukin2) is used for?

Back 63

Thrombocytopenia

Front 64

Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- sargamostim is used for?

Back 64

Recovery of Bone Marrow (it is a granulocyte-macrophage colony stimulating factor)

Front 65

Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- thrombopoietin is used for?

Back 65

Thrombocytopenia