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65 Cards in this Set

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Endocrine Drugs: Hydrocortisone, prednisone, triamcinolone, dexamtasone, bleclomethasone are examples of what kind of drugs?
Glucocorticoid
Endocrine Drugs: Glucocorticoids decrease the production of ___ and ____
Leukotrienes and prostanglandins
Endocrine Drugs: To treat Addison's disease, inflammation, immune suppression, asthma, use ____
Glucocorticoids
Endocrine Drugs: An important side-effect of Glucocortioid usage is ____
Iatrogenic Cushing's Syndrome
Endocrine Drugs: Buffalo hump, moon facies, truncal obesity, muscles wasting, thin skin, easy bruisability, osteoporosis, adrenocortical atrophy, peptic ulcers characterize what syndrome?
Cushing's Syndrome
Reproductive Drugs: Which two drugs inhibit cGMP phosphodiesterase, leading to smooth muscle relaxation in the corpus cavernosum and penile erection?
Sildenafil and Verdenafil --they fill the penis
Reproductive Drugs: What class of drugs are used tto treat erectile dysfunction
cGMP Inhibitors
Reproductive Drugs: CGMP inibitors taken with ____have a high risk of liofe-threeatening hypotension
nitrates
Reproductive Drugs: Which drugs is a partial agonist of estrogen recpetors in the pituitary gland, stimulating increase in LH and FSH, which stimulates ovulation to treat infertility
clomiphene
Reproductive Drugs: Clomiphene's side effects include:
Hotflashes, ovarian enlargment, multiple simultaneous pregnancies, visual disturbances
Reproductive Drugs: What abortifacient is a competitite inhibitor of preogestins at progesterone recpetor and may lead to heavy menstrual-like bleeding?
Mifepristone (RU486)
Reproductive Drugs: The advantage of this drug is that it is reliable, decreases incidence of ectopic pregnancy, decreases risk of pelvic infections, and regulates menses; however it also puts you in a hypercoagulable stat and may increase your trigylcerides, weight, and blood pressure
Oral Contracpetices - syntheitc progestins/estrogen
Rheumatologic Drugs: ____is converted to uric acid which leads to gout
Xanthine (converted from excess purines)
Rheumatologic Drugs: This drug depolymerizes microtubules, impairing leukocyte chemotaxis and degranulation, and used to treat acute gout
Colchicine
Rheumatologic Drugs: This drugs inhibits reabsorption of uric acid and used to treat chronic gout
Probenecid
Rheumatologic Drugs: This drug is used to treat chronic gout, but also inhbits secretion of penicillin
Probenecid
Rheumatologic Drugs: This drugs inhibits xanthine oxidase decreasing the conversion fo xanthine to uric acid
Allopurinol
Oncologic Drugs: What are the cell cycle specific oncologic drugs
antimetabolites, plant alkaloids, stroid hormones, bleomycin, paclitaxel, etoposide
Oncologic Drugs: What are the cell cycle Nonspecific oncologic drugs?
alkylating agents and antibiotics
Oncologic Drugs: ____is an S-phase-specific anti-metabolite that is an folic acid analog that inhibits dihydrofolate reducate decreasing dTMP(thymidine and purines) and decreaing DNA/prtein synthesis.
Methotrexate
Oncologic Drugs: ____is an S-phase-specific anti-metabolite that is a pyrmidine analog which complexed to folic acid, inhibiting thymidylate synthase, decreasing dTMP and decreasing DNA/protein synthesis
5-Fluorouracil (5-FU)
Oncologic Drugs: Myelosuppression by methotrxate is reversible with ____
leucovorin (folinic acid) rescue
Oncologic Drugs: Which drug blocks purine synthesis and is used to treat leukemias, lymphomas (not CLL or Hodgkins)
6-mercaptopurine (6-MP)
Oncologic Drugs: Which drug alkylates DNA and is used to treat CML?
Busulfan
Oncologic Drugs: Which drug inhibits DNA polymerase and is used to treat AML?
cytarabine
Oncologic Drugs: This drug used to treat Leukemias and Lymphomas is metaboilized by xanthine oxidase
6-mercaptopurine (6-MP)
Oncologic Drugs: Used to treat leukemias, lymphomas, choricarcinoma, sacromas, rheumatoid arthritis, psoriasis, and can be an abortifacient; it may lead to myelosuppression
Methotrexate
Oncologic Drugs: Used to treat colon cancer and other solid tumors, basal cell carcinoma (topically)
5-Fluorouracil (5-FU)
Oncologic Drugs: Myelosuppression by 5-FU is ______
Not reversible
Oncologic Drugs: This drug used to treat AML may lead to leukopenia, thrombocytopenia, megaloblastic anemia?
cytarabine
Oncologic Drugs: This drugs used to treat CML may lead to pulmonary fibrosis and hyperpigmentation?
Busulfan
Oncologic Drugs: ____is an alkylating agent acivated by liver that covalently x-links DNA at guanine N-7, and is used to treat non-hodgkin's lymphoma, breast/ovarian carcinomas
cyclophosphamides
Oncologic Drugs: ____ alkylates DNA after bioactivation and can cross the BBB and treats brain tumors (glioblastoma multiforme)
Nitrosoureas (Carmustine, lomustine, semustine, streptozocin)
Oncologic Drugs: ____acts like an alkylating agent, x-linking via hyrdolysis of Cl and platinum; used to treat testicular, bladder, lung carcinomas
Cisplatin
Oncologic Drugs: This alkylating agent can cause myelosuppression and hemorhagic cystitis
cyclophosphamides
Oncologic Drugs: This combination of drugs is used to treat Hodgkin's and myelomas, sarcomas, and solid tumors (breast, ovary, lung)
ABVD: Adriamycin, Bleomycin, Vinblastine, Dacarbazine
Oncologic Drugs: ____noncovalently intercalates in DNA, creating breaks to decrease replication and transcription
Doxorubicin (adriamycin)
Oncologic Drugs: ____intercalates DNA strands and induces free radical fromation which causes strand breaks
Bleomycin, Dactinomycin
Oncologic Drugs: Which drugs causes cardiotoxicity, alopecia, and myelosuppression?
Doxorubicin (adriamycin)
Oncologic Drugs: Which drug is used to trat oat cell carcinoma of the lung and prostate/testicular carcinoma?
Etoposide
Oncologic Drugs: This combination of drugs is used to treat lymphoma, CLL, Hodgkin's, Wilm's tumor, choriocarcinoma
MOp (Mustargen, Oncovin (Vincristine), Procarbazine (Matulane), Prednisone)
Oncologic Drugs: Which glucocorticoid may trigger apoptosis and may even work on nondividing cells
Prednisone
Oncologic Drugs: This drug is a G2-phase specific inhibitor of Topisiomerase II, leaving double strand breaks in DNA following DNA replication
Etoposide
Oncologic Drugs: This drug used to treat testicular cancer and lymphomas may cayse pulmonary fibrosis, skin chnages, and myelosuppression
Bleomycin, Dactinomycin
Oncologic Drugs: This drugs used as an immunosuppressant and in lymphomas may cause acne, osteoporosis, hypertension, peptic ulcers, hyperglycemia, psychosis?
Prednisone
Oncologic Drugs: ____is an estrogen receptor mixed agonist/antagonist that blocks the binding of estrogen to ER+ cells.
Tomoxifen/Raloxifene
Oncologic Drugs: ____is n M-phase-specific alkaloid that binds to tubulin and blocks polymerization of microtubules, preventing spindle formation
Vincristine and Vinblastine
Oncologic Drugs: ____is an M-phase-specific agen that binds to tubulin and hyperstabilizes the polymerized microtubules, so that the mitotic spindle cannot break down
Paclitaxel
Oncologic Drugs: What drugs is used to treat breast cancer, but may increas the risk of endometrial carcinomas and hot flashes
Tomoxifen
Oncologic Drugs: Side-effects of Vinblastine include….
VinBASTine BLASTs Bone Morraow, causing myelosupression, as well as neurotoxicity and paralutic ileus.
Oncologic Drugs: Side effects of Paclitaxel include….
Myelosupression and hypersensitivity
Immunosuppressants and Cytokine Therapy: This drug binds to cyclophilins, blocking differentiation and activation of T cells mainly by inhibiting IL2 production
cyclosporine
Immunosuppressants and Cytokine Therapy: This antimetabolite derivative of 6-mercaptopurine interferes with the metabolism and synthesis of nucleic acid, therefore toxic to proliferating lymphocytes
azathioprine
Immunosuppressants and Cytokine Therapy: This potent immunosuppressive drug binds to the FK-binding protein and inhibits secretion of IL2 and other cytokines
tacrolimus (FK506)
Immunosuppressants and Cytokine Therapy: This drug is used to suppress organ rejection after transplantation, but may predispose patient to viral infections and lymphoma
cyclosporine
Immunosuppressants and Cytokine Therapy: Azaothioprine is used to in what setting?
Kidney transplants, autoimmune disorders (glomerulonephritis, hemolytic anemia)
Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- Aldesleukin (interleukin-2) is used for?
Renal cell carcinoma, metastatic melanoma
Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- Erythropoietin (epoetin) is used for?
anemia
Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- Filgrastim is used for?
Recovery of Bone Marrow; it is a granulocyte colony stimulating factor
Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- alpha interferon is used for?
Hep B/C, Kaposi's sarcoma, leukemia, malgnant melanoma
Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- beta interferon is used for?
Multiple Sclerosis
Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- gamma interferon is used for?
Chronic Granulomatous disease
Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- oprelvekin (interleukin2) is used for?
Thrombocytopenia
Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- sargamostim is used for?
Recovery of Bone Marrow (it is a granulocyte-macrophage colony stimulating factor)
Immunosuppressants and Cytokine Therapy: Recombinant Cytokine- thrombopoietin is used for?
Thrombocytopenia