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19 Cards in this Set
- Front
- Back
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What is the major function of alpha 1 receptors?
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increase vascular smooth muscle contraction
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What are the major functions (2) of alpha 2 receptors?
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1. decrease sympathetic outflow
2. decrease insulin release |
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What are the major functions (5) of beta 1 receptors?
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1. increase HR
2. increase contractility 3. increase renin release 4. increase lipolysis 5. increase aqueous humor formation |
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What are the major functions (3) of beta 2 receptors?
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1. vasodilation
2. bronchodilation 3. increase glucagon release |
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What is the major function of M1 receptors?
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CNS
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What is the major function of M2 receptors?
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decrease HR
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What is the major function of M3 receptors?
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increase exocrine gland secretions
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What is the major function of D1 receptors?
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relaxes renal vascular smooth muscle
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What is the major function of D2 receptors?
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modulates transmitter release, especially in brain
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What are the major functions (4) of H1 receptors?
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1. increase nasal and bronchial mucus production
2. contraction of bronchioles 3. pruritis 4. pain |
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What is the major function of H2 receptors?
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increase gastric acid secretion
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What is the major function of V1 receptors?
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increase vascular smooth muscle contraction
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What is the major function of V2 receptors?
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increase water permeability and reabsorption in the collecting tubules of the kidney
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5 receptors involving Gq?
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"H.A.V.M.M":
1. H1 2. alpha1 3. V1 4. M1 5. M3 (unique in this group) |
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What happens when a substrate binds to a Gq receptor?
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Gq--> PLC--> lipids cleaved --> PIP2 -->*IP3--> increase Ca
(and) -->*DAG--> PKC * = branch point |
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What are the groups of receptors (5) involving Gs?
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"B.V.H. B.D.":
1. beta 2 2. V2 3. H2 4. beta 1 (unique in group) 5. D1 (unique in group) |
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What happens after a substrate binds to the Gs receptor?
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Gs--> adenylcyclase --> ATP --> cAMP --> INCREASE
PKA |
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What happens after a substrate binds to the Gi receptor?
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Gi--> adenylcyclase --> DECREASE cAMP --> DECREASE PKA
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What are the groups of receptors (3) involving Gi?
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"A.M.D.":
1. alpha 2 2. M2 3. D2 |
