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110 Cards in this Set
- Front
- Back
Pt presents with decreased pain and temperature sensation over lateral aspects of both arms. What is the lesion?
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Syringomyelia
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Penlight in p's R eye produces bilateral pupillary constriction. When moved to the L eye, there is paradoxical dilatation. What is the defect?
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Atrophy of the optic nerve
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Pt describes a decreased prick sensation on the lateral aspect of her leg and foot. A deficit in what muscular action can also be expected?
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Dorsoflexion and eversion of foot (common peroneal nerve)
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Elderly woman presents with arthritis and tingling over the lateral digits of her R hand. What is the diagnosis?
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Carpal tunnel syndrome, median nerve compression
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20 year-old dancer reports decreased plantar flexion and decreased sensation over the back of her thigh, calf, and lateral half of her foot. What spinal nerve is involved?
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Tibial (L4-S3)
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Woman involved in a motor vehicle accident cannot turn her head to the L and has right shoulder droop. What structure is damaged?
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R CN XI (runs through the jugular foramen with IX and X); innervates the sternocleidomastoids and trapezius muscles
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Man presents with one wild, flailing arm. Where is the lesion?
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Contralateral subthalamic nucleus -- hemiballismus
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Pt with a cortical lesion does not know that he has a disease. Where is the lesion?
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R parietal lobe
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Pt cannot protrude tongue toward L side and has R-sided spastic paralysis. Where is the lesion?
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Left medulla, CN XII
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Teen falls while rollerblading and hurts his elbow. He can't feel the medial part of his palm. Which nerve and what injury?
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ulnar nerve due to broken medial condyle
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Pt cannot blink high right eye or seal his lips and has mild ptosis on the right side. What is the diagnosis and which nerve is affected?
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Bell's palsy, CN VII
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Field hockey player presents to the ER after falling on her arm during practice. X ray shows midshaft break of hte humerous. Which nerve and artery are most likely damaged?
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radial nerve and deep brachial artery, which run together
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Pt complains of pain, numbness and a tingling sensation. On exam, she has wasting of the thenar eminence. What is the diagnosis and what nerve is often affected?
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Carpal tunnel syndrome, median nerve
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Woman presents with headache, visual disturbance, galactorrhea, and amenorrhea. What is the diagnosis?
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Prolactinoma
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43-year-old man experiences dizziness and tinnitus. CT shows enlarged internal acoustic meatus. What is the diagnoses?
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Schwannoma
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25-year-old female presents with sudden uniocular vision lass and slightly slurred speech. She has a history of weakness and parasthesias that have resolved. What is the diagnosis?
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MS
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10-year-old child "spaces out" in class (e.g., stops talking midsentence and then continues as if nothing had happened). During spells, there is a slight quivering of lips. What is the diagnosis?
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Absence seizures
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What is the role of astrocytes?
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physical support, repair, K metabolism, help maintain the BBB. Astrocyte marker: GFAP
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What is the role of ependymal cells?
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inner lining of ventricles
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What is the role of microglia?
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phagocytosis
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What is the role of oligodendroglia?
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central myelin production; can myelinate up to 30 CNS axons
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What is the role of Schwann cells?
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peripheral myelin production; each Schwann only myelinates one peripheral axon
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Where do microglia originate from?
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Like all macrophages, microglia arise from the mesoderm. All other CNS/PNS supportive cells originate in the ectoderm.
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What is the most abundant glial cell in white matter?
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oligodendroglia
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Which sensory corpuscle is involved in light discriminatory touch of glabrous (hairless) skin?
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Meissner's
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Which sensory corpuscle is involved in pressure, coarse touch, vibration and tension?
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Pacinian
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Which sensory corpuscle is involved in light, crude touch of finger tips, hair follicles and hard palate?
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Merkel's
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The cochlea, vestibule and semicircular canals is filled with what Na-rich fluid?
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Perilymph (peri - think outside of the cell, Na)
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The cochlear duct, utricle, saccule, and semicircular canals have tubes filled with what K-rich fluid?
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endolymph (think inside the cell, K)
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Which ear structures detect linear acceleration?
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Utricle and saccule; contain maculae
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Which structures in the ear detect angular acceleration?
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Semicircular canals (contain ampullae; ampullae/angle)
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Which area of the cochlea detects high-frequency sound?
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base (narrow and stiff)
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Which area of the cochlea detects low-frequency sound?
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apex (wide and flexible)
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What 3 structures form the BBB?
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1. tight jnxns between nonfenestrated capillary endothelial cells
2. astrocyte processes 3. basement membrane |
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Vasogenic edem is caused by what pathopysiology?
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infarction leading to destroyed endothelial cells
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What cells cross the BBB more easily?
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nonpolar, lipid-soluble substances
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What are the main fnxns of the hypothalamus?
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TAN HATS
-Thirst and water balance -Adenohypophysis control via releasing factors -Neurohypophysis and median eminence relase hormones synthesized in hypothalamic nuclei -Hunger and satiety -Autonomic regulation; circadian rhythyms -temperature regulation -Sexual urges and emotions (Septal nucleus) |
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What are the two hormones released by the posterior pituitary?
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ADH and oxytocin
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What thalamic nuclei relays visual information?
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Lateral Geniculate Nucleus (LGN = light)
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What thalamic nuclei relays auditory information?
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Medial geniculate nucleus (MGN = music)
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What thalamic nuclei relays body sensation?
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Ventral posterior nucleus, lateral part (VPL)
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What thalamic nuclei relays facial sensation?
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Ventral posterior nucleus, medial part (VPM)
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What thalamic nuclei relays motor information?
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Ventral anterior/lateral (VA/VL)
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What is the fnxn of the limbic system?
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Famous 5 F's
-Feeding -Fighting -Feeling -Flight -Sex |
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What are the structures and what is the fnxn of the Basal ganglia?
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Substantia nigra
Globus pallidus (externus and internus) subthalamic nucleus D1 and D2 receptors Fnxn in voluntary movements and making postural adjustments |
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What disease is the result of decreasing input from the substantial nigra?
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Parkinson's
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What are the fnxns of the frontal lobe?
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Executive fnxns: planning, inhibition, concentration, orientation, language, abstraction, judgement, mood,motor regulation
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The anterior cerebral artery supplies what area(s) of the brain?
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medial surface of the brain; leg-foot area of motor and sensory cortices.
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The middle cerebral artery supplies what area(s) of the brain?
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lateral aspect of the brain, trunk-arm-face area of motor and sensory cortices, Broca's and Wernicke's speech area
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The posterior communicating artery supplies what area(s) of the brain?
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common area of anneurysm; causes CN III palsy
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The anterior communicating artery supplies what area(s) of the brain?
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most common site of Circle of Willis anneurysm; lesions may cause visual-field defects
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The Lateral striate arteries supply what area(s) of the brain?
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divisions of the middle cerebral artery; arteries of stroke; supply internal capsule, caudate, putamen, globus pallidus
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What are the signs of an anterior circle stroke?
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general sensory and motor dysfunction, aphasia
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What are the signs of a posterior circle stroke?
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cranial nerve deficits (vertigo, visual deficits), coma, cerebellar deficits (ataxia)
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What connects the lateral ventricle to the third ventricle?
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The foramen of Monroe (intraventricular foramen)
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What connects the 3rd ventricle to the 4th ventricle?
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cerebral aqueduct (aqueduct of Sylvius)
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How does CSF get from the 4th ventricle to the subarachnoid space?
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lateral = Foramen of Luschka
medial = Foramen of Magendie |
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State the locations of neurons and synapses for the dorsal column/medial lemniscus tract?
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1st order: DRG, ascends ipsi up spinal cord
1st synapse: nucleus cunneatus (arms) or gracilis (legs) 2nd order: decussates in medulla and ascends contralaterally 2nd synapse: VPL thalamus 3rd order neuron: sensory cortex |
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State the locations of neurons and synapses for the spinothalamic tract?
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1st order: A-delta and C fibers
1st synapse: ipsi grey matter of spinal cord 2nd order: decussates at anterior white commisure, ascends contra 2nd synapse: VPL thalamus 3rd order neuron: sensory cortex |
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State the locations of neurons and synapses for the lateral corticospinal tract?
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Upper motor neuron: 1' motor cortex, descends ipsi until decussates at medullary pyramids
1st synapse: cell body of anterior horn of spinal cord Lower motor neuron: leaves the spinal cord 2nd synapse: neuromuscular jnxn |
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What are the 5 nerve roots that comprise the brachial plexus?
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C5-8 and T1 (C5-7 branch off the long thoracic)
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An injury to the shaft of the humerus will damage which nerve resulting in what motor deficits?
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Radial nerve, loss of triceps brachii, brachioradialis and extensor carpi radialis longus
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An injury to the supracondyl of the humerus damages which nerve causing what motor deficits?
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Median nerve, loss of power in any of the arm muscles, forearm pronation, wrist flexion, finger flexion, thenar atrophy
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An injury to the medial epicondyle damages which nerve causing what motor deficits?
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Ulnar nerve, impaired wrist flexion and adduction, impaired adduction of the thumb and the ulnar 2 fingers
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An injury to the sugical neck of the humerus or anterior shoulder dislocation damages which nerve causing what motor deficits?
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Axillary nerve, loss of deltoid aciton
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The posterior half of the skull cap is the landmark dermatome for which nerve?
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C2
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The location of a high turtleneck shirt is the landmark dermatome for which nerve?
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C3
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The location of the top of a low collar shirt is the landmark dermatome for which nerve?
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C4
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The nipple is the landmark dermatome for which nerve?
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T4 (T4 at the TEAT pore)
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The xiphoid process is the landmark dermatome for which nerve?
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T7
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The umbilicus is the landmark dermatome for which nerve?
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T10 (belly butTEN)
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The inguinal ligament is the landmark dermatome for which nerve?
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L1 (L1 is IL)
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The kneecap is the landmark dermatome for which nerve?
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L4
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Erection and sensation of penile and anal zones is the landmark dermatome for which nerve?
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S2, S3, S4 (2,3,4 keep the penis off the floor)
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What is the role of muscle spindles in muscle fiber movement?
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Muscle spindles monitor muscle length (help you pick up a heavy object when you didn't know how heavy it was)
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What is the role of golgi tendon organs in muscle fiber movement?
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Golgi tendon organs monitor muscle tension; inhibitory feedback to alph motor neurons (make you drop a heavy object you have been holding too long)
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What motor reflex is normal during the first year of life but is pathological in adults?
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Babinsky sign - dorsiflexion of the big toe but fanning of the other toes
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Provide the name, function and type of nerve for CN I.
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Olfactory
Smell Sensory |
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Provide the name, function and type of nerve for CN II
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Optic
Sight Sensory |
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Provide the name, function and type of nerve for CN III
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Oculomotor
eye movement, pupil constriction, accomodation, eyelid opening Motor |
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Provide the name, function and type of nerve for CN IV
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Trochlear
eye movement Motor |
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Provide the name, function and type of nerve for CN V
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Trigeminal
Mastication, facial sensation Both |
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Provide the name, function and type of nerve for CN VI
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Abducens
Eye movement (lateral rectus) Motor |
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Provide the name, function and type of nerve for CN VII
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Facial
Facial movement, taste to anterior 2/3 of tongue, lacrimation, salivation(submaxillary and sublingual glands), eyelid closing Both |
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Provide the name, function and type of nerve for CN VIII
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Vestibulocochlear
hearing,balance Sensory |
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Provide the name, function and type of nerve for CN IX
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Glossopharyngeal
Taste from posterior 1/3 of tongue, swallowing, salivation (parotid), monitoring carotid body and sinus chemo- and baroreceptors Both |
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Provide the name, function and type of nerve for CN X
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Vagus
taste from epiglottic region, swallowing, palate elevation, talking, thoracoabdominal viscera, aortic arch chemo- baroreceptors Both |
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Provide the name, function and type of nerve for CN XI
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Accessory
head turning, shoulder shrugging Motor |
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Provide the name, function and type of nerve for CN XII
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Hypoglossal
tongue movement Motor |
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Motor cranial nerves are located where in the tegmentum of brainstem?
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medial nuclei (motor=medial)
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Sensory cranial nerves are located where int he tegmentum of the brainstem?
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Lateral nuclei
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The Pons is home to which CNs?
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V,VI,VII,VIII
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The medulla is home to which CNs?
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IX, X, XI, XII
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The midbrain is home to which CNs?
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III, IV
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What is the function and which CNs run through the Nucleus Solitarius?
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Visceral sensory information (taste, baroreceptors, gut distension)
VII, IX, X (sensory=solitary) |
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What is the function and which CNs run through the Nucleus ambiguous?
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Motor innervation of pharynx, larynx, and upper esophagus (swallowing, palate elevation)
IX, X, XI |
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What is the function and which CNs run through the Dorsal motor nucleus?
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Sends autonomic (parasympathetic) fibers to the heart, lungs, and upper GI
No CNs |
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CN I runs through which skull structure?
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Cribiform plate
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Which CN and vessels run through the optic canal?
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CNII, opthalmic artery, central retinal vein
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Which CN and vessels run through the superior orbital fissure?
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CNs III, IV, V(1), VI, opthalmic vein
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Which CN and vessels run through the Foramen Rotundum?
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CN V(2)
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Which CN and vessels run through the Foramen Ovale?
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CN V(3)
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Which CN and vessels run through the foramen spinosum?
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middle meningeal artery
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Which CN and vessels run through the internal auditory meatus?
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CN VII, VII
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Which CN and vessels run through the Jugular foramen?
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CNs IX, X, XI, jugular vein
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Which CN and vessels run through the hypoglossal canal?
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CN XII
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Which CN and vessels run through the Foramen Magnum?
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spinal roots of CN XI, brainstem, vertebral arteries
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What 3 muscles close the jaw?
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Masseter, temporalis, Medial
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What muscle opens the jaw?
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lateral pterygoid
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Trace the pupillary light reflex
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light in either retina sends a signal via CNII to pretectal nuclei in midbrain that activate Edinger-Westphal nuclei; pupils contract bilaterally--even if light is only in one eye
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