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50 Cards in this Set

  • Front
  • Back

Calculate SV

LVEDV-LVESV

Calculate EF

Ejection fraction:


(SV/LVEDV)x100

Calculate cardiac output

Q= SVxHR

myocardial oxygen consumption estimated by..

RPP= (HRxSBP)/100


rate pressure product

Hemodynamic Response RPP

High > 300High Intermediate 250 - 300Intermediate 200 - 250Low Intermediate 150 - 200Low 100 - 150

Arteries

deliver blood

Arterioles

Resistance vessels - another name for arterioles due to their ability to vasodilate and vasoconstrict; changing diameter allows them to control the flow of blood

Capillaries

Exchange vessels – all exchange of oxygen and carbon dioxide occur here

Venules

made of smooth mm, affect capillary pressure, dump into veins

veins

Capacitance vessels - another name for veins, owing to their distensibility, which enables them to pool large volumes of blood and become reservoirs for blood

Hematocrit?


in men.. in women

the ratio of blood cells to total blood volume, expressed as a percentage


Adult males: 42-54%Adult females: 38-46%

Mean Arterial Pressure (MAP)

MAP = (PP/3) + DBP2 (5th Korotkoff sound)


MAP = (PP/2) + DBP1 (4th Korotfoff sound)


Determines organ and tissue perfusion

Total Peripheral Resistance (TPR)

Q = MAP/TPR

medulla oblongata has 3 control centers which are

vasomotor center


cardiac accelerator center


cardiac inhibitor center

vasomotor center responsible for

vasodilation of skeletal muscle arterioles


vasoconstriction of visceral arterioles


(sympathetic outflow, accelerator N)

Cardio accelerator center and cardio inhibitor center work with...

CA: inc. heart rate and contractility


CI: heart dec. and so does contractility


(parasympathetic outflow, vagus N)

Anatomical Sensors and FactorsAffecting Control

a. Higher brain centersb. Systemic receptorsa. Baroreceptorsb. Stretch receptorsc. Chemoreceptorsd. Muscle joint receptors


high brain centers

cerebral cortex: emotional factors, motor cortexhypothalamus: input from cortex, body temp

chemoreceptors

inc. in CO2 pressure, inc. in H ions, dec. in pressure of O2 leads to general vasoconstriction

Muscle receptors

mechanical: inc. movement leads to inc. sympathetic outflow


metabolic: inc. activity causes in. in metabolites which leads to inc. in sympathetic flow

systemic receptors

Baroreceptors (aortic and carotid bodies): respond to inc. MAP leads to inc. parasymp. outflow and dec. symp. outflow




Stretch receptors (R atrium): inc. venous return leads to inc. symp. outflow

Neurohormonal Control


• Epinephrine/Norephinephrine• Alosterone/ADH


memorize this hahahaha



Fick equation


Q = (VO2/a-vO2diff)


what is inotropic and what is chronotropic

Stroke volume.. heart rate

VO2 max

greatest amount of oxygen that the body can take in,transport, and utilize during heavy exercise


VO2max= (HR max) * (SVmax) * (a-vO2 diff max)


diastole


systole



filling phase (relaxation)


ejection phase (contraction)



fluids move from ____ to _____

high pressure to low pressure

Primer pump


power pump

atrium


ventricle



the pressure changes in the _____ side of the heart are greater than _____ side of the heart but the volume of blood is the _________

left, right, same volume

why does left have greater pressure

volume of blood taken to greater distances than right

why must volumes stay the same with left and right

otherwise there would be a backdrop of blood in one of the circuits. Leads to congestive heart failure

as the electrical impulse passes from atrium to ventricle there is approx. ____ delay allowing for greater filling time for the ventricle

0.10 sec

blood moves passively to ventricle and fills_____ but contracts to top it off to fill with ____

70-75%, 100%

EDV

end diastolic volume: amt. of blood in each vent. at the end of vent. diastole

ESV

end systolic volume: amt. of blood remaining in each vent. at the end of vent. systole

Ejection fraction definition

percentage of EDV represented by SV

cardiac reserve

difference btween resting and maximal CO

Factors controlling SV

For EDV: filling time, venous return


For ESV: preload, contractility, afterload

Factors affecting EDV: inc. _____ decreases _____

heart rate, filling time

During exercise venous return is increased by 3 principle mechanisms

vasoconstriction: dec. vol. capacity of the veins to store blood>>> movement back to the heart


via symp. constriction of smooth mm in the veins




Muscle pump: one way valves in the veins, rhythmic muscle contractions facilitate movement of blood back to the heart




respiratory pump: rhythmic pattern of breathing also acts as a mechanical pump inc. thoracic pressure>>> inc. abdominal pressure, blood moves from high to low pressure

Preload

degree of stretching experienced during ventricular diastole

length tension relationship

stretching beyond its optimal length generally does not occur bc ventricular expansion is limited by myocardial CT, fibrous skeleton and pericardium

frank starling mechanism

inc. blood in the ventricles causes a stronger ventricular contraction to inc. the amt. ejected


"more in more out"

Contractility


changed in contractility caused by..

amt. of force produced by each contraction




1. autonomic stimulation>> symp. stimulation inc. HR (NE and E stimulate cardiac muscle)


2. hormones>> E, NE, glucagons and thyroid hormones inc. contractility


3. changes in ion concentration:


hypercalcemia: inc. cardiac muscle excitability


hypocalcemia: dec. cantractation


hyperkalemia: depol. and inhibition of repol. therefore contractions become weak and irregular


hypokalemia: hyperpol. and HR and BP dec.

afterload

amt. of tension the contracting vent. must produce the force necessary to force open the semilunar valve and eject blood.


inc. in afterload= inc. isovolumetric contraction


dec. duration of ventricular ejection


inc. ESV and dec. SV

Factors affecting HR:

1) autonomic NS: symp. inc. HR; parasymp. dec. HR


2) hormones: E, NE, thyroid hormone inc. HR and contractility


3) changes in ion concentration: dec. K produces hyperdepol and dec. HR, changes in Ca have more important effects on contractility


4) changes in body temp-- dec. temp= dec. HR (depol. of SA node)



mammalian dive reflex

massive vasoconstriction and HR < 46 bpm (parasymp)


inc. in temp>> inc. sweating and dec. plasma vol. (dec. SV>> inc. HR)

how to find TPR


why important

viscosity* total length/ radius^4




total length only changes with age so only viscosity changes really... TPR goes up with viscosity and total length




get blood at high speeds with tissues that need it (vasodilate w/ tissues that need it most, vasoconstrict w/ tissues that dont need it)

rise in HR after 45 min causes___

dec. SV