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13 Cards in this Set
- Front
- Back
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Cimetidine (Tagamet)
H2-Receptor (H2-R) Antagonist Agent That Reduce Acid Secretion |
Inhibit basal acid secretion by about 60%; less effective at inhibiting acid secretion induced by gastrin and cholinergic stimulation (as occurs after a meal)
Effective at inhibiting nocturnal acid secretion. Well-tolerated |
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omeprazole (Prilosec), esomeprazole(Nexium)
Proton-Pump Inhibitor Agents That Reduce Acid Secretion |
Inhibit the H+/K+ ATPase (the proton pump) via disulfide bonding. pro-drugs. With increased intragastric pH, pepsinogen in less efficiently converted to pepsin. interference with calcium absorption.
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Magnesium hydroxide, Aluminum hydroxide gel, Sodium bicarbonate
Antacids Agents That Reduce Intragastric Acidity |
Act by neutralizing gastric acid, thus raising the pH. Antacids are basic compounds composed of a metal ion (Al3+, Mg2+, Na+) and a base (e.g. OH-, HCO3-)
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Sucralfate
Agents That Promote Mucosal Defense |
a salt of sucrose (Glucose + Fructose) complexed to sulfated aluminum hydroxide. It forms a viscous gel that neutralizes stomach acid, inhibits pepsin, and provides a physical protective barrier around the ulcer.
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Triple therapy
Combination Therapies for Treating PUD When H. pylori Is Present |
Omeprazole combined with amoxicillin and clarithromycin(OAC).
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Quadruple therapy
Combination Therapies for Treating PUD When H. pylori Is Present |
Omeprazole, bismuth subcitrate, metronidazole, tetracycline (OBMT).
BMT is formulated in one pill; omeprazole is administered in a separate pill. |
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Gastroesophageal Reflux Disease (GERD): Treatment
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Antacids (mild), Cimetidine (mild-to-moderate), Omeprazole (moderate-severe), and Prokinetic agents (Metoclopramide) increasines smooth muscle contraction in the small intestine promoting gastric emptying and relieves pressure on the LES.
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Diphenhydramine (Benadryl)
Antiemetic Drug |
Histamine H1-receptor blocker
Dramamine is a combination of Diphenhydramine and 8-chlorotheophylline (counteracts drowsiness) |
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ondansetron
Antiemetic Drug |
5-Hydroxytryptamine (5-HT3)-receptor blockers
For treating vomiting caused by anti-cancer drugs |
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lactulose (fructosegalactose)
Drugs That Influence Movement Through the GI Tract Laxatives accelerate the passage of food through the colon |
Osmotic laxative
Increase the fluid volume in the colon |
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Senna
Drugs That Influence Movement Through the GI Tract Laxatives accelerate the passage of food through the colon |
Stimulant laxative
Contains an alkaloid (anthraquinone) that stimulates peristalsis of the colon |
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Metamucil
Drugs That Influence Movement Through the GI Tract Laxatives accelerate the passage of food through the colon |
Bulk-forming laxative
Contains Psyllium seed husks. Holds water, expands the stool, and promotes peristalsis of the colon. |
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loperamide (a synthetic opiate)
Antidiarrheal drug |
Anti-motility agent. acts through m-opioid receptors to decrease the tone of the longitudinal smooth muscles of the intestinal wall. more water to be absorbed out of the fecal matter. opioid agonist w/o bbb passing. OTC drug (Imodium)
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