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20 Cards in this Set
- Front
- Back
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Drug Interactions
Penicillins |
Decreased effect from tetracyclines and aminoglycosides (controversial)
Increased effect from neuromuscular blocking agents and synergistic effect with aminoglycosides |
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Drug Interactions
Cephalosporins |
Aminoglycosides and loop diuretics may increase the probability of nephrotoxicity
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Drug Interactions
Macrolides |
Big drug interactions with antacids, fluconazole, anticoagulants, carbamazepines, cyclosporin, digoxin, HMG-CoA reductase inhibitors, and theophylline
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Drug Interactions
Tetracyclines |
Antacids, anticoagulants, antiepileptics, iron and oral contraceptives
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Drug Interactions
Nitrofurantoin |
Antacids containing magnesium
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Drug Interactions
FQ |
Antacids/heavy metals, anticoagulants, theophylline, quinidine, procainamide, amiodarone, sotalol, and hypokalemia/hypomagnesiumia
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Drug Interactions
Glycopeptide |
Avoid agents associated with nephrotoxicity (aminoglycosides, cyclosporin, amophotericin B, NSAIDS) and ototoxicity (aminoglycosides, loops)
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Drug Interactions
Aminoglycosides |
Avoid agents associated with nephrotoxicity (vancomycin, cyclospirin, amphotericin B, NSAIDS) and ototoxicity (vancomycin, loops). May enhance neuromuscular blocking agents.
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Drug Interactions
Sulfonamides |
CYP2C9 enzyme inhibitor, anticoagulants, methotrexate, sulfonylureas, cyclosporin
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Drug Interactions
Lincosamides |
May enhance neuromuscular blockade if used with neuromuscular blocking agents.
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Drug Interactions
Metronidazole |
CYP2C9, 3A3 to 3A7 enzyme inhibitor
phenytoin/phenobarbital may decrease metronidazole efficacy may increase lithium levels |
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Drug Interactions
Carbapenems |
Cyclosporin and Ganciclovir may enhance CNS activity resulting in seizures
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Drug Interactions
Chloramphenicol |
CYP2C9 enzyme inhibitor
Avoid barbiturates, hydantoins, rifampin, anticoagulants |
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Drug Interactions
Rifampin |
substrate of CYP2A6, 2C8, 2C9, 3A4
inducer of CYP1A2, 2A6, 2B6, 3A4 Rifampin + pyrazinamide = hepatotoxic reaction Reduces plasma concentration of: anticoagulants, contraceptives, FQ, digoxin, cyclosporin, levothyroxine, protease inhibitors/non-nucleoside reverse transcriptase inhibotors |
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Drug Interactions
Streptogramin |
CYP450 3A4 inhibitor
Increases: cyclosprin, nifedipine, midazolam, protease inhibotors, and carbamazepine |
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Drug Interactions
Oxalodinones |
Has no CYP450 metabolism
Adrenergic agents (dopamine, epinephrine) can cause increases in blood pressure |
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Drug Interactions
Monobactams |
Potential nephrotoxicity and ototoxicity if used with aminoglycosides
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Drug Interactions
Lipopeptides |
Possible interaction with warfarin so monitor INR
HMG-CoA may potentiate myopathy and CPK elevations |
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Drug Interactions
Ketolides |
Telithromycin is a strong inhibitor and inducer of CYP 3A4
Contraindicated with Cisapride and Pimozide because of increased QT interval Can interact with some HMG-CoA inhibitors - simvastatin, atorvastatin, lovastatin. Cyclosporin, carbamazepine, felodipine, verapamil, carbamazepine, venlafaxine, digoxin, moxifloxacin, gatifloxacin, itraconazole, ketoconazole - NOT worth it. |
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Drug Interactions
Glycylcycline |
Tigecycline decreases the clearance of warfarin
Oral contraceptives may be less effective Relatively safe drug |
