Exam 1 Pharmacology 521

Front 1

Reserpine

Back 1

blocks VMAT, depletes catecholamines, prevents release of NE

Front 2

Cocaine

Back 2

NET and DAT inhibitor, prolonging of action of dopamine and NE in synapse

Front 3

Imipramine

Back 3

NET inhibitor, prolongs action of NE in synapse by blocking reuptake

Front 4

Amitriptyline

Back 4

NET inhibitor, prolongs action of NE in synapse by blocking reuptake

Front 5

Phenelzine

Back 5

Irreversible MAOI: blocks destruction of catecholamines, nonselective

Front 6

Tranylcypromine

Back 6

Irreversible, nonselective MAOI; blocks destruction of catecholamines

Front 7

Isocarboxazid

Back 7

Irreversible, nonselective MAOI; blocks destruction of catecholamines.

Front 8

Selegiline

Back 8

Selective irreversible MAO-B inhibitor MAOI

Front 9

Pargyline

Back 9

Selective MAO-B MAOI

Front 10

Nialamide (Nardil)

Back 10

MAO-I, nonselective

Front 11

Entacapone

Back 11

COMT inhibitor, increases dopamine, no peripheral action

Front 12

Tolcapone

Back 12

COMT inhibitor, increases dopamine, no peripheral action

Front 13

Phenoxybenzamine

Back 13

α-receptor antagonist, nonselective, irreversible, causes vasodilation

Front 14

Propranolol

Back 14

β-blocker, nonselective, does not block α receptors, blocks vasocontriction, reduces CO

Front 15

Clonidine

Back 15

α2 agonist, reduce sympathetic output of CNS

Front 16

Phenylephrine

Back 16

α1 agonist, vasocontrictor

Front 17

Methoxamine

Back 17

α1 agonist, vasoconstrictor, used in treatment of shock

Front 18

Methyldopa

Back 18

inhibitor of L-amino acid decarboxylase (enzyme that converts DOPA--> dopamine) = decrease dopamine

Front 19

Atenolol

Back 19

β1 blocker- blocks vasoconstriction

Front 20

Metoprolol

Back 20

β1 blocker, used in mild-moderate heart failure and after first MI, can prolong life

Front 21

Botulinum toxin

Back 21

binds presynaptic terminals, blocks ACh release

Front 22

Darifenacin (Enablex)

Back 22

M3 receptor antagonist, prevents muscle contraction

Front 23

Dobutamine

Back 23

β1 receptor agonist, increases contractility and CO

Front 24

Terbutaline

Back 24

β2 agonist, inhaled bronchodilator

Front 25

Prazosin

Back 25

α1 antagonist, blocks vasconstriction

Front 26

Yohimbine

Back 26

α2 antagonist--> more NE release that activates α1 receptors

Front 27

Atropine

Back 27

blocks ALL M-ACh receptors

Front 28

Methacoline

Back 28

Nonselective M receptor agonist

Front 29

Carbachol

Back 29

M and N type agonist

Front 30

Bethanechol

Back 30

M-ACh agonist, NO N-receptor effects

Front 31

Pilocarpine

Back 31

M receptor agonist, used for glaucoma, dry mouth

Front 32

Metoclopramide

Back 32

cholinergic agonist and dopamine antagonist

Front 33

Cevimeline

Back 33

M3 agonist, like Pilocarpine is a sialogogue (induce salivation)

Front 34

Scopolamine

Back 34

M-ACh antagonist

Front 35

Belladonna alkaloids

Back 35

M antagonist

Front 36

Ipratropium

Back 36

Nonselective M receptor blocker- inhibits bronchoconstriction and mucus secretion

Front 37

Tiotroprium (Spiriva)

Back 37

Selective M1 and M3 antagonist-bronchodilator

Front 38

Tolterodine (Detrol)

Back 38

nonselective M receptor antagonist- reduces contraction

Front 39

Trospium (Sanctura)

Back 39

nonselective muscarinic antagonist- reduces contraction

Front 40

Oxybutynin

Back 40

Nonselective M receptor antagonist- reduces contraction

Front 41

Solifenacin (Vesicare)

Back 41

Selective M3 antagonist- reduces contraction

Front 42

Homatropine

Back 42

M-receptor antagonist used in the eye

Front 43

Tropicamide

Back 43

M-antagonist

Front 44

Methscopolamine

Back 44

M-antagonist

Front 45

Glycopyrrolate

Back 45

M antagonist

Front 46

Mepenzolate

Back 46

M antagonist

Front 47

Propantheline

Back 47

Nonselective M antagonist

Front 48

Physostigmine

Back 48

AChE inhibitor: more ACh in synapse

Front 49

Tacrine (Cognex)

Back 49

AChE inhibitor

Front 50

Edrophonium

Back 50

AChE inhibitor

Front 51

Donepezil (Aricept)

Back 51

AChE inhibitor- more ACh in synapse

Front 52

Neostigmine

Back 52

AChE inhibitor

Front 53

Pyridostigmine

Back 53

AChE inhibitor

Front 54

Demecarium

Back 54

AChE inhibitor

Front 55

Rivastgmine

Back 55

AChE inhibitor

Front 56

Echothiophate

Back 56

organophophorus AChE inhibitor-irreversible

Front 57

Galantamine (Razadyne)

Back 57

AChE inhibitor

Front 58

Ambenomium

Back 58

AChE inhibitor

Front 59

α-Methyltyrosine

Back 59

Tyrosine hydroxylase inhibitor

Front 60

Guanethidine

Back 60

catecholamine storage inhibitor

Front 61

Guanadrel

Back 61

catecholamine storage inhibitor

Front 62

Amphetamine

Back 62

catecholamine storage inhibitor

Front 63

Pseudoephedrine

Back 63

Catecholamine storage inhibitor

Front 64

Methylphenidate

Back 64

Catecholamine storage inhibitor

Front 65

Iproniazid

Back 65

Nonselective MAOI

Front 66

Brofaromine

Back 66

Reversible MAO-A inhibitor

Front 67

Befloxatone

Back 67

reversible MAO-A inhibitor

Front 68

Moclobemide

Back 68

reversible MAO-A inhibitor

Front 69

Oxymetazoline (Afrin)

Back 69

α1 agonist

Front 70

Tetrahydrazine (Visine)

Back 70

α1 agonist

Front 71

Guanabenz

Back 71

α2 agonist

Front 72

Guanfacine

Back 72

α2 agonist

Front 73

Isoproterenol

Back 73

nonselective β agonist

Front 74

Metaproterenol

Back 74

β2 selective agonist

Front 75

Albuterol

Back 75

β2 selective agonist

Front 76

Salmeterol (Serevent)

Back 76

β2 selective agonist

Front 77

Tamsulosin

Back 77

α1A antagonist

Front 78

Terozosin + Doxazosin

Back 78

α1 receptor antagonist

Front 79

Nadolol

Back 79

nonselective β antagonist

Front 80

Timolol

Back 80

nonselective β antagonist

Front 81

Labetolol

Back 81

blocks α1, β1 and β2

Front 82

Carvedilol

Back 82

blocks α1, β1 and β2

Front 83

Pindolol

Back 83

β blockers

Front 84

Acebutolol

Back 84

partial β1 agonist

Front 85

Esmolol

Back 85

β1 antagonist

Front 86

Celiprolol

Back 86

β1 antagonist, β2 agonist

Front 87

Hyoscyamine

Back 87

M- recepetor inhibitor

Front 88

Dicyclomine

Back 88

M-receptor inhibitor