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47 Cards in this Set
- Front
- Back
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OSELTAMIVIR MOA
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NEURAMINIDASE INHIBITOR
PREVENTS RELEASE/SPREAD OF VIRUS NORMALLY NEURAMINIDASE: INHIBITS RESP SECRETION, CLEAVES SIALIC ACID SO VIRUS CANNOT BE CLEAVED... CATALYZES VIRUS RELEASE FROM INFECTED CELLS |
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ACYCLOVIR MOA
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DNA CHAIN TERMINATION
INCORPORATES TO VIRAL DNA - HAS ONLY 1 HYDROXYL GROUP, SO NEXT BASE CAN'T ATTACH |
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ENFUVIRTIDE MOA
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HIV FUSION INHIBITOR
BIND GLYCOPROTEIN 41 BLOCK FUSION OF VIRUS AND HOST CELL MEMBRANE |
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EFAVIRENZ MOA
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NNRTI
DIRECTLY BINDS AND INHIBITS REVERSE TRANSCRIPTASE NO REQUIRE ACTIVATION/INTEGRATION INTO VIRAL DNA LIKE NRTI |
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HIV PROTEASE INHIBITOR AE
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LIPODYSTROPHY (FAT ACCUMULATION)
INSULIN RESISTANCE/DIABETES HYPERLIPIDEMIA INCREASED LIVER FXN TEST *INHIB P450* |
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PREFERRED RX HIV
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NNRTI + 2 NRTI *CONTRA PREG*
(EFAVIRENZ + LAMI + ZIDO) PI + 2 NRTI (LOPINAVIR/RITONAVIR + LAMI+ ZIDO) |
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RX SYPHILIS
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PENECILLIN, TETRACYCLINE
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METHICILLIN, NAFCILLIN, OXACILLIN CLASSIFICATION
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anti-STAPHylococcal PENECILLIN
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CLAVULANATE, SULBACTAM, TAZOBACTAM MOA
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BETA LACTAMASE INHIBITOR
PROTECTS PENECILLIN FROM BETA LACTAMASE NO ANTIMICROBIAL ACTIVITY BY ITSELF |
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PROBENECID EFFECT ON PEN EXCRETION
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COMPETITIVE INHIBITOR OF RENAL TUBULAR EXCRETION OF PENECILLIN - INCREASES T1/2
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DOC LISTERIA
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AMPICILLIN +/- SULBACTAM
i need a LIST of AMPs |
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1st generation parental cephalosporin
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cefazolin
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2nd generation parental cephalosporin
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cefotetan
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3rd generation parental cephalosporin
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ceftriaxone
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4th generation parental cephalosporin
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cefepime
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2ND GENERATION CEPHALOSPORIN USE
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"THE TITAN IS FURIOUS FOR GETTING PROZAC"
CEFOTETAN, CEFUROXIME, CEFPROZIL URI MIXED AEROBE/ANAEROBE INFEC OTITIS MEDIA SINUSITIS G+/G- H. influenza E. aerogenes Neisseria Proteus mirabilis E.Coli Klebsiella pneumoniae Serratia marcenes |
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ANTIPSEUDOMONAL CEPHALOSPORIN
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CEFTAZIDIME - 3RD GEN, PARENTAL
"GIVE TAZ A DIME TO EAT PSEUDOMONAS" |
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FOSFOMYCIN USE
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G- ENTERO
ACUTE UNCOMPLICATED UTI CYSTITIS 1 SINGLE 3G DOSE |
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VANCOMYCIN ANTIMICROBIAL SPECTRUM
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MRSA, M SENSITIVE, PENECILLIN RESISTANT STREP/ENTERO
G+/G- C. DIFF PSEUDOMEMBRANOUS COLITIS |
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MUPROCIN USE
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IMPETIGO
INFECTED SKIN LESIONS NASAL COLONIZATION MRSA G+ COCCI TOPICAL |
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MUPROCIN MOA
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INHIBIT TRNA FORMATION
COMPETE WITH ISOLEUCINE FOR ISOLEUCINE TRNA SYNTHETASE |
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DOC RICKETTSIA INFECTION
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TETRACYCLINE
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TETRACYCLINE AE
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TEETH DISCOLORATION
ENAMEL HYPOPLASIA PHOTODERMATITIS BONE GROWTH PROB |
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MACROLIDE MOA
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ERYTHROMYCIN, CLAIRITHROMYCIN, AZITHROMYCIN
BLOCK PEPTIDYL TRANSFERASE - BLOCK TRANSLOCATION/INHIBIT PROTEIN SYNTHESIS IRREVERSIBLY BIND 50S RIBOSOME @ 23SRRNA SUBUNIT |
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ERYTHROMYCIN DRUG INTERACTION
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INHIBIT P450
INCREASE [] THEOPHYLLINE (COPD) WARFARIN CARBAMAZEPINE (CNS TOX, SEVERE ATAXIA) LOVASTATIN (MYOPATHY, RHABDOMYOLYSIS) |
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STREPTOMYCIN USE
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PLAGUE, TULAREMIA, RESISTANT TB
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CLINDAMYCIN USE
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ANAEROBIC INFECTIONS ABOVE DIAPHRAGM - C. PROFRINGENS, B. FRAGILIS
NECROTIZING FASCIITIS WITH PENECILLIN |
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CLINDAMYCIN AE
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C. DIFF PSEUDOMEMBRANOUS COLITIS, FEVER, DIARRHEA, COLITIS
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AMINOGLYCOSIDE AE
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TOBRAMYCIN, STREPTOMYCIN, GENTAMYCIN
NEPHROTOXICITY (ESP WITH CEPHALOSPORIN) OTOTOXICITY (ESP WITH LOOP DIURETIC) CN VIII DELAYED -> PERM |
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SULFONAMIDE MOA
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INHIBIT FOLATE SYNTHASE
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TRIMETHOPRIM MOA
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INHIBIT DIHYDROFOLATE REDUCTASE
DECREASE PURINE, PYRIMIDINE, AA SYNTHESIS |
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SULFONAMIDE/TRIMETOPRIM USE
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PNEUMONIA - P JIROVECI, NOCARDIA
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SULFONAMIDE AE
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CRYSTALLURIA (NEPHROTOXICITY)
HYPERSENSITIVITY (RASH, ANGIOEDEMA) STEVEN JOHNSON SYNDROME - ERYTHEMA MULTIFORME HEMOLYTIC ANEMIA (G6PD DEF) MACROCYTIC ANEMIA (FOLATE DEF) DISPLACES OTHER DRUGS FROM ALBUMIN (WARFARIN) |
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FLUOROQUINOLONE MOA
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INHIBIT DNA GYRASE (G-)
ATTACHES TO A SITE INHIBIT TYPE IV TOPOISOMERASE (G+) |
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FLUOROQUINOLONE RESISTANCE MOA
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BACT RESISTANCE TO A SITE - DNA GYRASE
DECREASE # PORIN IN OUTER MEMBRANE, INHIBIT TOPOISOMERASE ACCESS TO CELL |
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FLUOROQUINOLONE AE
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ARTHROPATHY
TENDINOPATHY CNS EXCITATION - INSOMNIA, SEIZURES AVOID KIDS |
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DAPTOMYCIN USE
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MRSA, VRE, VRS
SKIN INFECTION SOFT TISSUE INFECTION DIABETIC FOOT INFECTIONS BURNS |
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ISONIAZID MOA
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ACTIVATED BY CATALASE PEROXIDASE
INHIBIT MYCOLIC ACID SYNTHESIS |
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ISONIAZID RESISTANCE MOA
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MUTATION CATALASE PEROXIDASE (KATg GENE)
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ISONIAZID AE
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HYPERSENSITIVITY
PYRIDOXINE DEF PERIPHERAL NEUROPATHY OPTIC NEUROPATHY AGE DEPENDENT HEPATITIS SEIZURE G6PD DEF HEMATOLOGIC TOX |
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WHAT DO YOU GIVE TO PREVENT NEUROTOXICITY WITH ISONIAZID
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B6
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WHO HAS MORE AE IN ISONIAZID PT
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SLOW ACETYLATOR
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RIFAMPIN MOA
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INHIBIT RNAP
INHIBIT INITIATION STEP OF RNA SYNTHESIS |
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RIFAMPIN RESISTANCE MOA
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DECREASE AFFINITY RNAP
DECREASE PERMEABILITY MUTATION IN BACTERIAL DNA DEPENDENT RNAP FOR DRUG |
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RIFAMPIN AE
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HYPERSENSITIVITY
HEPATITIS RED-ORANGE DISCOLORATION TEARS, SALIVA, URINE |
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PYRAZINAMIDE AE
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HYPERURICEMIA
GOUT RASH JOINT ACHE HEPATITIS HEMATOLOGIC EFFECTS |
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ETHAMBUTIDE AE
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IMPAIRED COLOR VISION
DOSE DEPENDENT OPTIC NEURITIS |
