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26 Cards in this Set
- Front
- Back
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3 types of growth disorders?
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Primary (inherited, inborn)
Secondary (environment, disease) Normal Variant (most common) |
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Three Flavors of Primary Growth Disorders
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Dysmorphic
Disproportionate SGA |
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Types of Dysmorphic Primary Growth Disorders?
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Turner's
T-21 Russell-Silver Noonan's |
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Different Causes of Secondary Growth Disorders?
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Malnutrition
Chronic Disease Endocrinopathy Psychosocial Deprivation |
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Causes of Normal Variant small size?
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Familial Short Stature
Constitutional Delay Idiopathic Short Stature |
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What do we test in order to ascertain growth hormone levels?
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IGF-1
IGFBP-3 |
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what is IGF-1 and why do we measure it?
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its a GH dependent peptide and promotes the effects of GH.
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What is IGFBP-3 and why do we measure it?
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Its a GH-dependent carrier protein of IGF-1. Its level reflects the daily GH production
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How does nutrition affect IGF-1 and IGFBP-3?
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IGF-1 is nutrition dependent.
IGFBP-3 is less nutrition dependent |
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If there is a GH deficiency, what happens to IGF-1 and IGFBP-3 levels?
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they're both lowered
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When do you measure length instead of height?
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0-36 months
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How do you calculate mid-parental height?
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Girls = [(Dad-5in) + Mom]/2
Boys = [Dad + (Mom+5in)]/2 |
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What is the Target Height?
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Mid-Parental Ht +/- 2SD
(1SD = 2inches) |
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What are some "reasons for concern" as far as growth goes?
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Sustained Growth Velocity < 5cm/yr between ages 3-12
Large disparity between predicted ht and actual Growth Plot crosses two major centiles Dysmorphism or Disproportion |
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How can you acquire GH deficiency?
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Idiopathic
Tumors (craniopharyngioma CNS insults (infection, trauma) |
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Sx's of GH Deficiency?
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Growth Velocity always below normal
Often Asymptomatic IGF-1 and IGFBP-3 are good markers |
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Most Common issue with Turner's Syndrome?
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45X (missing an X)
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Common Fts of Turner's?
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Disproportionate Shortness
Gonadal Failure Heart and Renal Defects Orthopedic, Learning, and Lymphatic Dysfunction |
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What gene is affected by Turner's?
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SHOX
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Interesting locations of SHOX expression?
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4th Metacarpal
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How often do Turner's pts have heart defects?1
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30%
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What kind of heart defects are associated w/ Turner's?
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Coarctation of Aorta
Bicuspid Aortic Valve issues Aortic Atresia |
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What is a skeletal sign of Turner's?
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Cubitus Valgus
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Rx of Turner's?
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GH supplements (even though they aren't GH def)
Estrogen to feminize |
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Crazy possibility w/ Turner's?
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Spontaneous Pregnancy
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If a Female has unexplained short stature...
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she is turner's till proven otherwise
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