Ettinger Feline Inflammatory Liver Dz

Front 1

Why is the term cholangitis being used in cats instead of cholangiohepatitits?

Back 1

The inflammatory changes are surrounding the bile ducts and generally not extending into the parenchyma

Front 2

What are the two major types of Fel inflammatory liver disease?

Back 2

neturophillic cholangitis
lymphocytic cholangitis
(liver fluke)

Front 3

Cholangitis in cats is generally due to some of these diseases vs. dogs

Back 3

FIP
Toxoplasmosis
RX reaction
FIV
Triaditis
- Dog generally are ideopathic

Front 4

What are some Feline non-liver causes of inflammatory liver disease (5)

Back 4

FIP
protozoal (toxoplasmosis)
bartonella
RX (tetracyclines/diazepam)

Front 5

What is the most common cause of liver disease in cats?

Back 5

ideopathic lipidosis

Front 6

What is the second most common cause of liver disease in cats?

Back 6

cholangitis

Front 7

This type of inflammatory liver disease is most commonly seen in young to middle aged (SEX) cats.

Back 7

neutrophilic cholangitis
Males

Front 8

What are the two major types of inflammatory liver disease?

Back 8

neturophillic cholangitis
lymphocytic cholangitis
(liver fluke)

Front 9

What are some non-liver causes of feline inflammatory liver disease (4)

Back 9

FIP
protozoal (toxoplasmosis)
bartonella
RX (tetracyclines/diazepam)

Front 10

What is the most common cause of liver disease?

Back 10

ideopathic lipidosis

Front 11

What is the second most common cause of liver disease?

Back 11

cholangitis

Front 12

This disease occurs in middle aged to older cats

Back 12

neutrophilic cholangitis

Front 13

What are the clinical signs of feline neutrophilic cholangitis?

Back 13

Vomiting - MC
jaundice
fevel

Front 14

What occurs with acute neutrophilic cholangitis at the cellular level?

Back 14

Neturophils infilatrate the bile duct lumen and surrounding epithelium. Can invade the parencyma and lead to abscesses
necrosis of bile duct

Front 15

What occurs at the cellular level of chronic neutrophilic cholangitis?

Back 15

fibrosis and bile duct proliferation.

Front 16

What other diseases are known to occur with feline neutrophilic cholangitis (acute or chronic)?

Back 16

triaditis - IBD, pancreatitis, and cholangitis

Front 17

What labratory values would you expect with Feline neutrophillic cholangitis?

Back 17

MC is increase in ALT
+/- ALP, GGT increased
Leukocytosis with L shift

Front 18

What do you see on ultrasound for feline neutrophillic cholangitis?

Back 18

gallbladder distention
thickening of gallbladder wall
sludging of bile

Front 19

Triaditis is more common in this form of cholangitis

Back 19

neutrophillic

Front 20

Cholelithiasis in cats generally occurs with this disease?

Back 20

neutrophillic cholangitis

Front 21

What bacteria are associated with N0 cholangitis?

Back 21

E. coli - MC
Entercoccus
Strep
Clostridium
Bacteriodes

Front 22

What ABs should be started for feline neutrophilic cholangitis?

Back 22

Clavamox
Cephalexin
Fluroquinolones
Metronidazole
Combo - 4-8 weeks

Front 23

Besides Abs, what should also be used for TX with feline neutrophilic cholangitis?

Back 23

Fluid support
pain support
steriods for anti-inflamatory support if Abs have been instutued

Front 24

What age is feline lymphocytic cholangitis most common in?

Back 24

Young cats initally (<4 yrs age); however, C/S are less severe and cats are sicker longer. May not present until older.

Front 25

What is the etiology of feline lymphocytic cholangitis?

Back 25

Unknown, but suspect immune mediated

Front 26

What are presenting signs for feline lymphocytic cholangitis?

Back 26

jaundice
ascititis
Do not appear ill

Front 27

Labratory changes that can occur with feline lymphocytic cholangitis? Abdominocentesis?

Back 27

mild elevation: ALT, ALKP,bilirubin, and GGT
abdominocentesis - yellow fluid with high protein

Front 28

What a a differential for lymphocytic cholangitis?

Back 28

FIP
(although these cats have pyrexia and inappetance)

Front 29

Treatment for feline lymphocytic cholangitis?

Back 29

corticosteriods
urodeoxycholate
AB is indicated on culture
Antioxidents

Front 30

TX options for the ascities

Back 30

centesis
furosemide
low sodium diet

Front 31

Prognosis for cats with lympocytic cholangitis

Back 31

those with jaundice do better than those with ascities
MST 37 months

Front 32

What type of cholangitis is generally considered a form of neutrophilic cholangitis?

Back 32

mixed inflammatory cholangitis

Front 33

What are some of the clinical signs of mixed inflammatorycholangitis?

Back 33

waxing/wayning chronic illness
inappetence
lethargy

Front 34

What is TX for mixed inflammatory cholangitis?

Back 34

-initate AB therapy while bacteria cultures are pending
- If positive TX for 4-6 weeks
- If no clinical improvment after 1-2 weeks, antiinflammatory dose with prednison with antibiotics.