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15 Cards in this Set
- Front
- Back
EtOH Uses
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bacteriostatic, reduce fever, reduce pain, solvent, methanol and ethylene glycol poisoning
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EtOH most prominent acute action
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CNS depression
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50-100 mg/DL
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disinhibition of RAS
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100-300 mg/DL
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cerebellum- affects coordination
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300-400 mg/DL
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midbrain- temp regulation and spinal reflexes
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450-600 mg/DL
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Medulla- respiratory depression
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Non-selective membrane effects
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EtOH "fluidizes" membranes, affecting phospholipids and proteins w/in
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Mech of CNS depression
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GABA-AR mediated inhibition
increases 5HT3 receptor actions increases Ach actions at nAchR |
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EtOH does not cross
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intact skin and urinary bladder
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EtOH biotransformation
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alcohol dehydrogenase
microsomal EtOH oxidizing sys catalase |
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disulfiram
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inhibits aldehyde dehydrogenase
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Interaction with aspirin
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gastric irritation and increased anti-platelet effect
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Interaction with insulin and chlorpropamide
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hypoglycemia
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interaction with guanethidine
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hypotension
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interaction with MAOIs
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hypertensive crisis
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