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15 Cards in this Set

  • Front
  • Back
EtOH Uses
bacteriostatic, reduce fever, reduce pain, solvent, methanol and ethylene glycol poisoning
EtOH most prominent acute action
CNS depression
50-100 mg/DL
disinhibition of RAS
100-300 mg/DL
cerebellum- affects coordination
300-400 mg/DL
midbrain- temp regulation and spinal reflexes
450-600 mg/DL
Medulla- respiratory depression
Non-selective membrane effects
EtOH "fluidizes" membranes, affecting phospholipids and proteins w/in
Mech of CNS depression
GABA-AR mediated inhibition
increases 5HT3 receptor actions
increases Ach actions at nAchR
EtOH does not cross
intact skin and urinary bladder
EtOH biotransformation
alcohol dehydrogenase
microsomal EtOH oxidizing sys
catalase
disulfiram
inhibits aldehyde dehydrogenase
Interaction with aspirin
gastric irritation and increased anti-platelet effect
Interaction with insulin and chlorpropamide
hypoglycemia
interaction with guanethidine
hypotension
interaction with MAOIs
hypertensive crisis