Es300: Lecture 5 Part 2 (Tissue Healing)

Front 1

Phases of Healing

Back 1

1) Inflammation

2) Proliferation

3) Remodeling

Front 2

Phase 1: Inflammation

What is it designed to do?

Back 2

»Designed to protect, localize, and rid the body of injurious agents.

Front 3

Phase 1: Inflammation

What happens to BF during inflammation?

Back 3

»Initial Vasoconstriction to Vasodilation

Front 4

Vasodilation - A Closer Look:

Edema & Exudate

Back 4

Edema - Increased secretion of fluid that causes swelling.

Exudate - Filtered fluid from swelling area.

Front 5

Vasodilation - A Closer Look:

Polymorphonuclear Leukocytes (PMN's) Purpose

Back 5

»*Neutrophils & Basophils are designed to remove debris.

Front 6

Vasodilation - A Closer Look:

Mast Cells Responsibilities

Back 6

»*Mast cells are responsible for increasing inflammation to the area due to the release of HISTAMINE.

Front 7

Bleeding Responses:

Clotting time

Back 7

»*3-5 minutes

Front 8

Signs of Inflammation

Back 8

»Redness

»Increased Temperature

»Loss of Function

»Edema

»Pain

Front 9

Signs of Inflammation:

Calor Dolor Tumor Rubor

Back 9

Calor - Warmth

Dolor - Pain

Tumor - Swelling

Rubor - Redness

Front 10

Phase 2: Proliferation

Purpose

Back 10

»Repair and Regeneration

»* Removal of Waste

Front 11

Phase 2: Proliferation

Signs of Proliferation

Back 11

»Redness

»Edema

»Sensitivity to pressure & tension

Front 12

Phase 3: Remodeling

Purpose

Back 12

»Reduction in chemicals, repair cells, and capillaries.

»Collagen transition

»Realignment

Front 13

Phase 3: Remodeling

Signs of Remodeling

Back 13

»*Decreased Redness

»*Increased Scar Density

»*Reduced Fluid Content

Front 14

Differences in Tissue:

Cartilage

Back 14

»Poor healer - Chondrocytes are limited to Matrix.

Front 15

Differences in Tissue:

Ligament

Back 15

»Good Healer

Front 16

Differences in Tissue:

Muscle (Satellite Cell Activity)

Back 16

»*Best healer

»Satellite Cell Activity - Sending message through other parts of body to aid in healing process.

Front 17

Differences in Tissue:

Which is a better healer, PNS or CNS?

Back 17

»PNS has a better chance of recovery.

Front 18

Bone Healing:

Osteoblast

Back 18

»Responsible for bone formation

Front 19

Bone Healing:

Osteocyte

Back 19

»Trapped osteoblasts

Front 20

Bone Healing:

Osteoclast

Back 20

»Responsible for bone resorption.

»Breaks up bone

Front 21

Bone Healing:

Phase 1

Back 21

»Trauma

»Hemorrhage

»Hematoma Formation (Swelling)

Front 22

Bone Healing:

Phase 2

Back 22

»Cellular Proliferation (Repair & Regeneration)

»*Callus Formation

Front 23

Bone Healing:

Phase 2; Callus Formation

Back 23

SOFT Callus - Weeks 2-3

HARD Callus - Weeks 4-16

Front 24

Bone Healing:

Phase 3

Back 24

»Ossification - Laying down new bone through osteoblasts.

»*Remodeling: Trabecular bone

Front 25

Bone Healing:

Phase 3; Remodeling --> Trabecular bone

Back 25

»Healed bone is harder than it was before.

Front 26

Bone Healing:

Factors Affecting Healing; Environment Concepts

Back 26

»Age

»Disease

»Size of Wound

»Nutrition