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9 Cards in this Set

  • Front
  • Back
Anucleated cells, hemoglobin, biconcave disks, produced in bone marrow, live for 90-120
Erythrocytes (RBCs)
Heme binding
O2-oxyhemoglobin
CO2-carbaminohemoglobin
CO-carboxyhemoglobin (strong binding)
Biconcave disk function
great surface area for O2-CO2 exchange
RBC shape maintainence
requires ATP-anaerobic glycolysis or pentose phosphate pathway
hypertonic solution
crenation-lose H2O
hyptonic solution
hemolysis-hemoglobin dissolves out leaving empty shell/ghost
lose their nucleus
before leaving bone marrow
destruction
spleen by macrophages and phagocytes in marrow
process of destruction
1. engulfed by lysosomal action
2. broken into heme and globin
3. heme broken into ferritin and bilirubin
4. globin dissociated into aa components
5. ferritin-sent to marrow
6. bilirubin-to liver, excreted w/ bile