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18 Cards in this Set
- Front
- Back
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What is ED?
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Persistent inability to achieve or sustain an erection suitable for satisfactory sexual performance
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What begins in the penis with sexual arousal?
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Parasympathetic innervation
Release of Nitric Oxide Vasodilation |
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What causes the erection?
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Nitric oxide actives cGMP
Blood Filling causes venous occlusion |
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What ends the erection?
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cGMP is removed by phosphodiesterase type 5
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What is the action of sildenafil?
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Selective inhibition of PDE 5
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What are the adverse effects of sildenafil?
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Hypotension
Priapism |
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What are the drug interactions with sildenafil?
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Nitrates
Alpha Blockers |
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What is the ending of the PDE 5 inhibitors?
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-afil
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What drugs are injected into the corpus cavernosum to achieve erection?
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Papaverine with phentolamine
Alprostadil |
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What is BPH?
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Benign Prostatic Hyperplasia
prostate enlargement caused by excessive growth of epithelial cells |
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Overgrowth of _____ causes mechanical obstruction while overgrowth of ____ causes dynamic obstruction.
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Epithelial
Smooth Muscle |
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What is Finasteride used for?
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BPH
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What is the action of Finasteride?
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Inhibits 5-alpha-reductase
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5-alpha-reductase converts testosterone into DHT the active form of testosterone in the prostrate.
T or F |
True
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What obstruction is Finasteride most effective against?
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Mechanical obstruction
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What obstruction is alpha 1 antagonist used for?
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Dynamic
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What is the action of Alpha 1 antagonist in BPH?
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Relaxes the smooth muscle in the bladder neck
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What is the ending of Alpha 1 Antagonists?
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-osin
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