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18 Cards in this Set

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  • Back
What is ED?
Persistent inability to achieve or sustain an erection suitable for satisfactory sexual performance
What begins in the penis with sexual arousal?
Parasympathetic innervation
Release of Nitric Oxide
Vasodilation
What causes the erection?
Nitric oxide actives cGMP
Blood Filling causes venous occlusion
What ends the erection?
cGMP is removed by phosphodiesterase type 5
What is the action of sildenafil?
Selective inhibition of PDE 5
What are the adverse effects of sildenafil?
Hypotension
Priapism
What are the drug interactions with sildenafil?
Nitrates
Alpha Blockers
What is the ending of the PDE 5 inhibitors?
-afil
What drugs are injected into the corpus cavernosum to achieve erection?
Papaverine with phentolamine
Alprostadil
What is BPH?
Benign Prostatic Hyperplasia
prostate enlargement caused by excessive growth of epithelial cells
Overgrowth of _____ causes mechanical obstruction while overgrowth of ____ causes dynamic obstruction.
Epithelial
Smooth Muscle
What is Finasteride used for?
BPH
What is the action of Finasteride?
Inhibits 5-alpha-reductase
5-alpha-reductase converts testosterone into DHT the active form of testosterone in the prostrate.
T or F
True
What obstruction is Finasteride most effective against?
Mechanical obstruction
What obstruction is alpha 1 antagonist used for?
Dynamic
What is the action of Alpha 1 antagonist in BPH?
Relaxes the smooth muscle in the bladder neck
What is the ending of Alpha 1 Antagonists?
-osin