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55 Cards in this Set
- Front
- Back
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What is a Spot Desmosome?
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Isolated Aspot welds at joining the intermiediate filament cytoskeletons of two cells at their lateral surfaces
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What is a Hemi Desmosome?
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Structures that anchor the intermediate filament cytoskeleton of an epithelium cell to the basal lamina.
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What are Membrane-microfilament binding proteins?
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membrane associated proteins that anchor the microfilament cytoskeleton to the plasma membrane by binding actin cross linking proteins.
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What are Adhesion Plaques?
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Structures that anchor microfilament stress fibers to the basal surface of many cells, particularly epithelial cells
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What are Zonula Occludens (tight jxns)?
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Thing bands of membrane around the apical perimeters of epithelial cells, held closely together by proteins such as occludin and claudin. they seal cells to preven diffusion of moleculs across the epithelium
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What are Belt Desomosomes?
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rows of structures anchoring actin microfilaments to the apical surface of epithelial cells, just beneath Zonula Occludens
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What are Zonular Occludens (tight jxns)?
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Thin bancs of membrane around the apical perimeters of epithelial cells, helpd closely together by proteins such as occludin and claudin.
THEY SEAL CELLS TO PREVENT DIFFUSION OF MOLECULES ACROSS THE EPITHELIUM |
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What is a Cricumferential Belt?
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Microfilament bundles (actin and myosin) that encricle the apical perimenter of epithelial cells at the level of the belt desmosome.
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What are Gap Junctions?
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Transmembrane complexes that ALLOW DIFFUSION of Small Molecules between cells to vesicles.
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What is the main function of Zonula Occludens?
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to seal epithelial layes against diffusion, by preventing molecules from passing between cells
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What are the 2 things Zonula Occludens binds between neighboring cells? and on what side of cell surface?
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- Membrane-Membrane
- Lateral Cell Surface |
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Does Zonula Occludens have any attachements? if so what?
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no attachments
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What type of epithelium is Zonula Occludens most typically associated with?
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-Simple Columnar Epithelium
- Pseudostratified Ciliated Columnar Epithelium |
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Where fo you find Simple Columnar Epithelium in our bodies?
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GI Tract: lining of stomach
-gall bladded -sm intestine -colon -gut tube |
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What kind of Epithelium do you find in the GI tract?
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Simple Columnar Epithelium
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Where can you find Pseudostratified Columnar Epithelium in our bodies?
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The RESPIRATORY SYS
- lining of trachea and bronchii - lining of vas deferens - epididymis |
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What is the main function of Gap Junctions?
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They allow for a nonspecific, except for size, diffusion of molecules. This allows for the cytoplasm of all the connected cells to be the same.
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What are Gap Junctions important for Signal transduction?
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They allow the transduction signal to propogate faster beause the cells share the same cytoplasm.
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What epithilium type(s) are Gap Junctions most typically found in the body?
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-Transitional Epithelium
-Stratified Cuboidal/Stratified Columnar -Simple Cuboidal Epithelium |
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Where in the body would you find TRANSITIONAL epithelium?
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- BLADDER
-Ureter -Urethra |
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What kind of Epithelium is associated with the bladder?
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Transitional Epithelium
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Where do you find Stratified Columnar/Stratified Cuboidal Epithelium in our bodies?
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Found in DUCTS
- Mammary Duct - Parotid Duct |
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What type(s) of epithelium are associated with ducts?
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Stratified Columnar/Cuboidal
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Where do you find Simple Cuboidal in our bodies?
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KIDNEY TUBULES
- sm ducts and exocrine glands |
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What type(s) of epithelium are associated with Kidney tubules?
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Simple cuboidal
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What are Belt Desomosomes?
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rows of structures anchoring actin microfilaments to the apical surface of epithelial cells, just beneath Zonula Occludens
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What are Zonular Occludens (tight jxns)?
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Thin bancs of membrane around the apical perimeters of epithelial cells, helpd closely together by proteins such as occludin and claudin.
THEY SEAL CELLS TO PREVENT DIFFUSION OF MOLECULES ACROSS THE EPITHELIUM |
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What is a Cricumferential Belt?
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Microfilament bundles (actin and myosin) that encricle the apical perimenter of epithelial cells at the level of the belt desmosome.
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What are Gap Junctions?
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Transmembrane complexes that ALLOW DIFFUSION of Small Molecules between cells to vesicles.
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What is the main function of Zonula Occludens?
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to seal epithelial layes against diffusion, by preventing molecules from passing between cells
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What are the function of cadherins and what type of cell junction are they associated with?
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They are transmembrane links that bind Ca2+
- assoc with Z. Adherens - they link the adapter proteins that are bound to the Belt Desomosomes |
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What do Z Adherens connect between neighboring cells?
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Cytoskelton-cytoskeleton
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Whcih junctions have microfilament attachments?
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- Zonula Adherens
- Focal Adhesions |
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Which junctions have intermediate filament attachements?
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- Spot Desmosomes
- Hemi-Desmosomes |
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What types of Epithelium are associed with Zonula Adherens?
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Simple Squamous Epithelium
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Where in the body can you find Simple Sqaumous Epithelium?
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CIRCULATORY SYSTEM
- vascular sys: ENDOTHELIUM (blood/lymph) - body cavities:MESOTHELIUM (visceral pleura, parietal pleura, peritoneum) - Respiratory spaces in LUNG - Bowman's Capsule in KIDNEY |
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What is an important function of Spot Desmosomes?
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mediate cell communication in the SKIN
- PROTECT AGAINS ABRASION |
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What kind of epithlium is associated with Spot Desmosomes?
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Stratified Squamous Epithelium
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Where in the body can you find Stratified Squamous Epithelium?
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- Epidermis of Skin
- lining of ORAL cavity - esophagus - lining of Vagina |
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What are the 2 characterizations used for Stratified Squamous?
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Keratinized or Nonkeratinized
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What is laminin and what cell junction is it associated with?
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Transmembrane protein that binds multiple factors on both sides of membrane
- associated with Hemi Desmosomes |
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What are focal adhesions?
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structures that anchor microfilament stress fibers to the basal surface of fibroblasts and cancer cells which have attached to the substratum.
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What do focal adhesions consist of?
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Integrin, adapter proteins and fibronectin, stress fiber
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What is the role of integrin in Focal Adhesions?
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binds fibronextin in the substratum
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What is a Band 3 Anion Transporter?
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They are transmembrane proteins of Erythrocytes.
- they serve as transport Proteins - but also as jxns, anchoring microfilament cytoskeleyon to plasma mem - this MAINTAINS RBC SHAPE |
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What are the transporters of Band 3 Anion transporter bounb by?
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They are bound by Ankyrin, which is tied to the cytoskeleton by spectrin.
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What is Dystrophin and what kind of cell is it found in?
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a microfilament crosslinking prtein in muscle cells?
- it anchorys cytoskel to mem |
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What results from Muscula Dystrophy?
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Degradation of muscle due to loss of dystrophin
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What are the 8 types of Epithelium?
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Simple Columnar
Psuedostratified ciliated columnar Transitional Stratified cuboidal/columnar Simple cuboidal Simple Squamous Stratified Squamous |
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What are examples of GAGs present in the ECM?
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Haluronic Acid
Chondroitin Sulfate Karatin Sulfate Heparin Sulfate |
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Who makes the Type III cells?
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Schwann cells, Hepatocytes, Smooth muscle cells
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Where is Type IV and VII Collagen? and who makes them?
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Basement membranes;
Endothelial cells, Mesothelial cells, Epithelial cells Muscle cells fibroblasts |
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What is Ehlers Danlos SYndrome? What does it affect?
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Heritable group of CT disorders
- affects collagen structure and function. Unstable collagen bundles |
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Who makes Type II Collagen?
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Chondrocytes
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Who makes Type I collagen?
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Fibroblast,
Osteoblast |
