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18 Cards in this Set
- Front
- Back
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1st line drug for tonic-clonic seizure?
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Phenytoin or valproic acid
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1st line drug for prevention of status epilepticus?
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Phenytoin
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1st line drug for simple partial seizure?
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Carbamazepine
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1st line drug for complex partial seizure?
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Carbamazepine
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1st line drug for trigeminal neuralgia?
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Carbamazepine
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1st line for partial seizures and tonic-clonic seizures in pregnant women and children?
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Phenobarbital
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Used for myoclonic seizures?
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Valproic acid
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1st line for absence seizures?
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Ethosuximide
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1st line for treatment of status epilepticus?
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Benzodiazepines (diazepam or lorazepam)
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Used for seizures of eclampsia?
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Benzodiazepines (diazepam or lorazepam)...
... BUT... 1st line for this is MgSO4 |
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Carbamazepine toxicities
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Blood dyscrasias
SIADH Stevens Johnson Syndrome Teratogen |
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Ethosuximide
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Fatigue
GI distress Headache Stevens-Johnson Synd |
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Phenytoin
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Gingival hyperplasia
Hirsuitism SLE-like syndrome Teratogen (fetal hydantoin syndrome) |
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Valproic acid
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Rare but fatal hepatotoxicity (LFTs)
Neural tube defects in fetus GI distress |
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Lamotrigene
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DIC
Angioedema Aplastic anemia Stevens-Johnson syndrome |
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MOA of phenytoin
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Blockade of Na+ channels
Increases refractory period Inhibits glutamate release from excitatory presynaptic cell |
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MOA of barbiturates
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Increase DURATION of Cl-channel opening
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MOA of benzodiazepines
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Increase FREQUENCY of Cl- channel opening
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