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19 Cards in this Set

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  • Back
Prospective cohort Defn
Investigator defines and studies exposure variables prior to occurence of D
Seven key questions to analyze a study
Question
Design
Cohort
Followup
Exposure
Disease
Confounders
Analysis
3 parts to follow-up
begin
end
procedures
6 keys to exposure
external
internal E-
Zero time
Classification
Measurement
Changes over time
4 keys to disease
Definition
Acertainment
Specificity/PPV
Sensitivity
4 keys to Analysis
Disease Occurrence
Effect Measure
Statistical method
Power
Follow-up: Procedure
How subject tracked over time for both ascertain D and changes in E (or other vars). Problems include loss to follow-up and selection bias
Exposure: External E- issues
If E- group used is there a healthy worker effect
Exposure: Internal E- issues
non-random sampling
Exposure: Classification
dose, duration, timing.
clinically relevent divisions
percentiles
Exposure: measurement issues
misclass causes information bias: lead to null hypothesis
Exposure: Change with follow-up
misclassification - information bias which leads to null
Disease: PPV issues
misclass leads to null
6 criteria for cohort members
Relevant to question
Eligible (in theory) to be E+
Prevalence E+ adequate
Susceptible to D
Incidence D Adequate
Can provide good data
Criteria for followup beginning
Unambiguous.
data collection event.
meeting criteria for inclusion.
recruitment can be overtime.
Criteria for followup ending
End of study
Study event
Death
any loss of followup
Common procedures for followup
Interview
Contacts
Tracing services
Public records
medicare
death cert.
Effects of Loss of followup
Seriously bias findings
When to use prospective trial
RCT can't be done
can't be answered with retrospective or case-control
Can afford cost and time