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9 Cards in this Set
- Front
- Back
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What is the question of a RCT?
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Does a new treatment work better than a control to treat or prevent a disease?
- Answer is ONLY applicable to that specific population and question |
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What are 3 types of treatments a placebo group might recieve?
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1. Masking placebo (sugar pill)
2. Positive Control (known to work) 3. Standard of Care (unblinded |
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What is the main strength of a clinical trial?
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Randomization
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Who are 4 individuals that could be blinded in a RCT?
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1. Subject - eliminate mind/body effects of believe in tx
2. Data Collector - eliminate (un)conscious bias in data collection 3. Tx personnel - eliminate (un)conscious bias in administration of tx 4. Statistician - eliminate (un)conscious bias in data manipulation |
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Who is blinded in a single, double, triple, and quadruple blined study?
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Single: Patient
Double: + data collector Triple: + treatment personnel Quadruple: + statistician |
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Must ALL patient data be analyzed (even if they drop out)?
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YES, under intention to treat model because strength of trial is randomization
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Is statistical significance all that is needed statistically in a RCT?
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NO. Example of migraine headaches: Very certain one was better, BUT difference was only 67% and 64%
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What are the 4 phases of clinical trials?
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Animal Testing
Phase I: Small group of human subjects Phase II: Larger group usually w/ disease of interest Phase III: Larger groups randomized (1,000's of ppl) Phase IV: Monitor use in general population |
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What is publication bias?
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Positive results more likely to be published
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