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15 Cards in this Set
- Front
- Back
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Holoenzyme
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complete with cofactor (vitamin, mineral, metal, NAD, FAD)
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Apoenzyme
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protein part only
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Metalloenzyme
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have metal cofactors (Fe, Cu, Zn, Mo, etc)
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What affects rxn rate?
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pH
Temperature Ionic composition Ligands - inhibitors, activators |
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ALP
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Alkaline Phosphatase for 5' phosphates in DNA, RNA, nucleotides, proteins
-Found in liver (bile duct cells), bone (osteoblasts) and kidney (brush border) -Less likely intestinal or placental |
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L-ALP
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Specific ALP test for damage to bile duct
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B-ALP
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bone growth, fracture, rickets, osteosarcoma
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Leukocyte-ALP
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polycythemia vera, myelofibrosis, metastatic breast and colorectal cancers
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AST
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Aspartate Aminotransferase (formerly SGOT)
Utilized in malate-aspartate shuttle Primary sources; Liver and skeletal muscle |
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ALT
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Alanine Aminotransferase (formerly SGPT)
Transfers amino group between alanine/pyruate -> glutamate/akg Liver primarily |
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LDH
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Lactate Dehydrogenase
Found in Heart Liver/Skeletal Muscle 5 tetrameric combinations |
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GGT
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Gamma glutamyl transferase/transpeptidate
Membrane bound involved in transport of AA into cells High in biliary epithelial cells, pancreas, and renal tubular cells Dx for cholestasis |
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CK
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Creatine kinase aka CPK (creatine phosphokinase)
Found in brain and muscle Most likely for muscle damage |
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AMS
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Amylase - dx for pancreatic disease
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LPS
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Lipase - Dx for intestinal tract or pancreas disease (combine with AMS)
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